Search Results - "Bothner, Brian"
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Aerobic bacterial methane synthesis
Published in Proceedings of the National Academy of Sciences - PNAS (06-07-2021)“…Reports of biogenic methane (CH₄) synthesis associated with a range of organisms have steadily accumulated in the literature. This has not happened without…”
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2
New Technologies for Studying Biofilms
Published in Microbiology spectrum (01-08-2015)“…Bacteria have traditionally been studied as single-cell organisms. In laboratory settings, aerobic bacteria are usually cultured in aerated flasks, where the…”
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3
Structure and Dynamics of Adeno-Associated Virus Serotype 1 VP1-Unique N-Terminal Domain and Its Role in Capsid Trafficking
Published in Journal of Virology (01-05-2013)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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4
Hepatitis B Virus Core Protein Phosphorylation Sites Affect Capsid Stability and Transient Exposure of the C-terminal Domain
Published in The Journal of biological chemistry (20-11-2015)“…Hepatitis B virus core protein has 183 amino acids divided into an assembly domain and an arginine-rich C-terminal domain (CTD) that regulates essential…”
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5
Comparative Analysis of Adeno-Associated Virus Capsid Stability and Dynamics
Published in Journal of Virology (01-12-2013)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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6
Acute stress reduces population-level metabolic and proteomic variation
Published in BMC bioinformatics (07-03-2023)“…Variation in omics data due to intrinsic biological stochasticity is often viewed as a challenging and undesirable feature of complex systems analyses. In…”
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An Aurora B-RPA signaling axis secures chromosome segregation fidelity
Published in Nature communications (25-05-2023)“…Errors in chromosome segregation underlie genomic instability associated with cancers. Resolution of replication and recombination intermediates and protection…”
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Demonstration of Protein-Based Human Identification Using the Hair Shaft Proteome
Published in PloS one (07-09-2016)“…Human identification from biological material is largely dependent on the ability to characterize genetic polymorphisms in DNA. Unfortunately, DNA can degrade…”
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Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes
Published in Nature communications (05-10-2023)“…Homologous recombination (HR) is an essential double-stranded DNA break repair pathway. In HR, Rad52 facilitates the formation of Rad51 nucleoprotein filaments…”
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Rtt105 regulates RPA function by configurationally stapling the flexible domains
Published in Nature communications (02-09-2022)“…Replication Protein A (RPA) is a heterotrimeric complex that binds to single-stranded DNA (ssDNA) and recruits over three dozen RPA-interacting proteins to…”
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Metalloproteomics Reveals Multi-Level Stress Response in Escherichia coli When Exposed to Arsenite
Published in International journal of molecular sciences (02-09-2024)“…The operon encodes a three-protein arsenic resistance system. ArsR regulates the transcription of the operon, while ArsB and ArsC are involved in exporting…”
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Gut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia
Published in Nature communications (13-01-2023)“…Familial dysautonomia (FD) is a rare genetic neurologic disorder caused by impaired neuronal development and progressive degeneration of both the peripheral…”
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Introducing the ArsR-Regulated Arsenic Stimulon
Published in Frontiers in microbiology (03-03-2021)“…The microbial operon encodes the primary bacterial defense response to the environmental toxicant, arsenic. An important component of this operon is the gene,…”
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14
Thermal Stability as a Determinant of AAV Serotype Identity
Published in Molecular therapy. Methods & clinical development (15-09-2017)“…Currently, there are over 150 ongoing clinical trials utilizing adeno-associated viruses (AAVs) to target various genetic diseases, including hemophilia (AAV2…”
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Arsenite oxidase also functions as an antimonite oxidase
Published in Applied and Environmental Microbiology (01-03-2015)“…Arsenic and antimony are toxic metalloids and are considered priority environmental pollutants by the U.S. Environmental Protection Agency. Significant…”
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Longitudinal analysis of the Five Sisters hot springs in Yellowstone National Park reveals a dynamic thermoalkaline environment
Published in Scientific reports (04-11-2022)“…Research focused on microbial populations of thermoalkaline springs has been driven in a large part by the lure of discovering functional enzymes with…”
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Metabolic Implications of Using BioOrthogonal Non-Canonical Amino Acid Tagging (BONCAT) for Tracking Protein Synthesis
Published in Frontiers in microbiology (13-02-2020)“…BioOrthogonal Non-Canonical Amino acid Tagging (BONCAT) is a powerful tool for tracking protein synthesis on the level of single cells within communities and…”
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Regulatory Activities of Four ArsR Proteins in Agrobacterium tumefaciens 5A
Published in Applied and environmental microbiology (15-06-2016)“…ArsR is a well-studied transcriptional repressor that regulates microbe-arsenic interactions. Most microorganisms have an arsR gene, but in cases where…”
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Mechanical coupling in the nitrogenase complex
Published in PLoS computational biology (04-03-2021)“…The enzyme nitrogenase reduces dinitrogen to ammonia utilizing electrons, protons, and energy obtained from the hydrolysis of ATP. Mo-dependent nitrogenase is…”
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Untargeted metabolomics profiling of oat ( Avena sativa L.) and wheat ( Triticum aestivum L.) infested with wheat stem sawfly ( Cephus cinctus Norton) reveals differences associated with plant defense and insect nutrition
Published in Frontiers in plant science (2024)“…Wheat stem sawfly (WSS), Cephus cinctus Norton, is a major pest of common bread wheat (Triticum aestivum L.) and other cultivated cereals in North America…”
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