Effect of a Low-Calorie Diet on Restoration of Normoglycemia in Obese subjects with Type 2 Diabetes

Type 2 diabetes mellitus (T2DM) is considered to be an inevitably progressive disease. Complex therapies add to the financial and psychological burden. Very low-calorie diets (LCDs) are emerging as an option in the management of type 2 diabetes. We performed a clinical audit of patients with T2DM wh...

Full description

Saved in:

Bibliographic Details
Published in:	Indian journal of endocrinology and metabolism Vol. 21; no. 5; pp. 776 - 780
Main Authors:	Bhatt, Anjali Amit, Choudhari, Priya K, Mahajan, Rutuja R, Sayyad, Mehmood G, Pratyush, Devi D, Hasan, Imtiaz, Javherani, Rajesh S, Bothale, Manish M, Purandare, Vedavati B, Unnikrishnan, Ambika Gopalakrishnan
Format:	Journal Article
Language:	English
Published:	India Medknow Publications and Media Pvt. Ltd 01-09-2017 Medknow Publications & Media Pvt. Ltd Medknow Publications & Media Pvt Ltd Wolters Kluwer Medknow Publications
Subjects:	Antihypertensive agents Brief Communication C-reactive protein Diabetes Diet Diet therapy Dosage and administration Drug therapy Endocrinology Gastrointestinal surgery Glucose Health aspects Insulin resistance Nutrition Obesity Proteins reversal Type 2 diabetes Ultrasound very low-calorie diet Weight control reversal type 2 diabetes very low-calorie diet Nutrition obesity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Type 2 diabetes mellitus (T2DM) is considered to be an inevitably progressive disease. Complex therapies add to the financial and psychological burden. Very low-calorie diets (LCDs) are emerging as an option in the management of type 2 diabetes. We performed a clinical audit of patients with T2DM who received 12 weeks of LCD. This case series documents that 6 out of 12 participants (median baseline HbA1c 9%) achieved HbA1c level in nondiabetes range with LCD despite stopping all antidiabetes medications. There was an improvement in serum triglycerides, HDL cholesterol, total cholesterol, C-Reactive protein, urine microalbumin, liver transaminases, liver fat and the indices of insulin resistance, beta cell secretory capacity, and insulin sensitivity. If long-term follow-up proves sustained benefits, such dietary restriction may be an alternative to more drastic options for reversal of type 2 diabetes. This may also help in changing the treatment perspective of a newly detected T2DM from an incurable and inevitably progressive disease to a potentially reversible disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2230-8210 2230-9500
DOI:	10.4103/ijem.IJEM_206_17