Search Results - "Botet, Miguel López"

Adaptive reconfiguration of the human NK‐cell compartment in response to cytomegalovirus: A different perspective of the host‐pathogen interaction by Muntasell, Aura, Vilches, Carlos, Angulo, Ana, López‐Botet, Miguel

“…As discussed in this review, human cytomegalovirus (HCMV) infection in healthy individuals is associated with a variable and persistent increase of NK cells…”
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Targeting NK-cell checkpoints for cancer immunotherapy by Muntasell, Aura, Ochoa, Maria C, Cordeiro, Luna, Berraondo, Pedro, López-Díaz de Cerio, Ascension, Cabo, Mariona, López-Botet, Miguel, Melero, Ignacio

“…Highlights • NK cells are cytotoxic lymphocytes with potential for cancer immunotherapy. • NK-cell numbers and function are regulated by surface receptors and…”
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The CD94/NKG2C+ NK-cell subset on the edge of innate and adaptive immunity to human cytomegalovirus infection by López-Botet, Miguel, Muntasell, Aura, Vilches, Carlos

“…Highlights • HCMV infection promotes a variable and persistent expansion of NKG2Cbright NK-cells. • This NK-cell subset displays distinctive phenotypic and…”
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Complete genomic characterization of a new KLRC2 allele, NKG2C03 by Asenjo, Judit, Muntasell, Aura, López‐Botet, Miguel, Moraru, Manuela, Vilches, Carlos

“…The novel NKG2C*03 allele encodes a hybrid of the NKG2C*01 and NKG2C*02 primary structures…”
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Imprint of human cytomegalovirus infection on the NK cell receptor repertoire by Gumá, Mónica, Angulo, Ana, Vilches, Carlos, Gómez-Lozano, Natalia, Malats, Núria, López-Botet, Miguel

“…Expression of the activating CD94/NKG2C killer lectin-like receptor (KLR) specific for HLA-E was analyzed in peripheral blood lymphocytes (PBLs) from healthy…”
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NK cells eliminate Epstein-Barr virus bound to B cells through a specific antibody-mediated uptake by Alari-Pahissa, Elisenda, Ataya, Michelle, Moraitis, Ilias, Campos-Ruiz, Miriam, Altadill, Mireia, Muntasell, Aura, Moles, Anna, López-Botet, Miguel

“…Epstein Barr virus (EBV) causes a highly prevalent and lifelong infection contributing to the development of some malignancies. In addition to the key role…”
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Diversity of NKG2C genotypes in a European population: Conserved and recombinant haplotypes in the coding, promoter, and 3′‐untranslated regions by Asenjo, Judit, Moraru, Manuela, Al‐Akioui‐Sanz, Karima, Altadill, Mireia, Muntasell, Aura, López‐Botet, Miguel, Vilches, Carlos

“…NK cells monitor altered molecular patterns in tumors and infected cells through an ample array of receptors. Two families of evolutionarily distant receptors…”
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NKG2C zygosity influences CD94/NKG2C receptor function and the NK‐cell compartment redistribution in response to human cytomegalovirus by Muntasell, Aura, López‐Montañés, María, Vera, Andrea, Heredia, Gemma, Romo, Neus, Peñafiel, Judith, Moraru, Manuela, Vila, Joan, Vilches, Carlos, López‐Botet, Miguel

“…Human cytomegalovirus (HCMV) infection promotes a persistent expansion of a functionally competent NK‐cell subset expressing the activating CD94/NKG2C…”
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Pretransplant adaptive NKG2C+ NK cells protect against cytomegalovirus infection in kidney transplant recipients by Ataya, Michelle, Redondo‐Pachón, Dolores, Llinàs‐Mallol, Laura, Yélamos, José, Heredia, Gemma, Pérez‐Sáez, María J., Vila, Joan, Costa‐García, Marcel, Raïch‐Regué, Dàlia, Vilches, Carlos, Pascual, Julio, Crespo, Marta, López‐Botet, Miguel

“…Cytomegalovirus (CMV) infection constitutes a complication for kidney transplant recipients (KTR) and CMV‐specific T cells reduce the risk of viral replication…”
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Haplotype-Based Analysis of KIR -Gene Profiles in a South European Population-Distribution of Standard and Variant Haplotypes, and Identification of Novel Recombinant Structures by Cisneros, Elisa, Moraru, Manuela, Gómez-Lozano, Natalia, Muntasell, Aura, López-Botet, Miguel, Vilches, Carlos

“…Inhibitory Killer-cell Immunoglobulin-like Receptors (KIR) specific for HLA class I molecules enable human natural killer cells to monitor altered antigen…”
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Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK‐cell subset distribution in children by Noyola, Daniel E., Fortuny, Claudia, Muntasell, Aura, Noguera‐Julian, Antoni, Muñoz‐Almagro, Carmen, Alarcón, Ana, Juncosa, Teresa, Moraru, Manuela, Vilches, Carlos, López‐Botet, Miguel

“…Human cytomegalovirus (HCMV) has been reported to reshape the NK‐cell receptor (NKR) distribution, promoting an expansion of CD94/NKG2C+ NK and T cells. The…”
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Interplay between Natural Killer Cells and Anti-HER2 Antibodies: Perspectives for Breast Cancer Immunotherapy by Muntasell, Aura, Cabo, Mariona, Servitja, Sonia, Tusquets, Ignasi, Martínez-García, María, Rovira, Ana, Rojo, Federico, Albanell, Joan, López-Botet, Miguel

“…Overexpression of the human epidermal growth factor receptor 2 (HER2) defines a subgroup of breast tumors with aggressive behavior. The addition of…”
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Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts by Gumá, Mónica, Budt, Matthias, Sáez, Andrea, Brckalo, Tamara, Hengel, Hartmut, Angulo, Ana, López-Botet, Miguel

“…CD94/NKG2C+ natural killer (NK) cells are increased in healthy individuals infected with human cytomegalovirus (HCMV), suggesting that HCMV infection may shape…”
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Interaction of the LILRB1 inhibitory receptor with HLA class Ia dimers by Baía, Diogo, Pou, Jordi, Jones, Des, Mandelboim, Ofer, Trowsdale, John, Muntasell, Aura, López‐Botet, Miguel

“…Leukocyte immunoglobulin‐like receptor subfamily B member 1 (LILRB1) has been reported to interact with a wide spectrum of HLA class I (HLA‐I) molecules,…”
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Reduced expansion of CD94/NKG2C+ NK cells in chronic lymphocytic leukemia and CLL‐like monoclonal B‐cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions by Puiggros, Anna, Blanco, Gonzalo, Muntasell, Aura, Rodríguez‐Rivera, María, Nonell, Lara, Altadill, Mireia, Puigdecanet, Eulàlia, Arnal, Magdalena, Calvo, Xavier, Gimeno, Eva, Abella, Eugènia, Abrisqueta, Pau, Bosch, Francesc, Yélamos, José, Ferrer, Ana, López‐Botet, Miguel, Espinet, Blanca

“…Introduction Dysregulated NK cell‐mediated immune responses contribute to tumor evasion in chronic lymphocytic leukemia (CLL), although the NK cell compartment…”
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Human Cytomegalovirus Antigen Presentation by HLA-DR+ NKG2C+ Adaptive NK Cells Specifically Activates Polyfunctional Effector Memory CD4+ T Lymphocytes by Costa-García, Marcel, Ataya, Michelle, Moraru, Manuela, Vilches, Carlos, López-Botet, Miguel, Muntasell, Aura

“…Natural killer (NK) cells play a dual role in the defense against viral pathogens by directly lysing infected cells as well as by regulating anti-viral T cell…”
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NKp46 and DNAM-1 NK-cell receptors drive the response to human cytomegalovirus-infected myeloid dendritic cells overcoming viral immune evasion strategies by Magri, Giuliana, Muntasell, Aura, Romo, Neus, Sáez-Borderías, Andrea, Pende, Daniela, Geraghty, Daniel E., Hengel, Hartmut, Angulo, Ana, Moretta, Alessandro, López-Botet, Miguel

“…Information on natural killer (NK)–cell receptor-ligand interactions involved in the response to human cytomegalovirus (HCMV) is limited and essentially based…”
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Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis by Zabalza, Ana, Vera, Andrea, Alari-Pahissa, Elisenda, Munteis, Elvira, Moreira, Antía, Yélamos, Jose, Llop, Mireia, López-Botet, Miguel, Martínez-Rodríguez, Jose E

“…Human cytomegalovirus (HCMV) infection has been recently associated with a low risk of multiple sclerosis (MS), yet the basis behind this observation remains…”
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Natural killer cell-mediated response to human cytomegalovirus-infected macrophages is modulated by their functional polarization by Romo, Neus, Magri, Giuliana, Muntasell, Aura, Heredia, Gemma, Baia, Diogo, Angulo, Ana, Guma, Monica, Lopez-Botet, Miguel

“…Variability in the NK cell response to HCMV infection of different functionally polarized macrophage populations may be relevant in the immunopathology of the…”
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Adaptive Features of Natural Killer Cells in Multiple Sclerosis by Moreira, Antía, Alari-Pahissa, Elisenda, Munteis, Elvira, Vera, Andrea, Zabalza, Ana, Llop, Mireia, Villarrubia, Noelia, Costa-García, Marcel, Álvarez-Lafuente, Roberto, Villar, Luisa María, López-Botet, Miguel, Martínez-Rodríguez, Jose E

“…Human cytomegalovirus (HCMV) has been recently related with a lower susceptibility to multiple sclerosis (MS). HCMV promotes an adaptive development of NK…”
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