Search Results - "Botella, Marlene"
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OPA1 deficiency impairs oxidative metabolism in cycling cells, underlining a translational approach for degenerative diseases
Published in Disease models & mechanisms (01-09-2023)“…Dominant optic atrophy is an optic neuropathy with varying clinical symptoms and progression. A severe disorder is associated with certain OPA1 mutations and…”
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Genetic background modulates phenotypic expressivity in OPA1 mutated mice, relevance to DOA pathogenesis
Published in Frontiers in molecular neuroscience (06-09-2023)“…Dominant optic atrophy (DOA) is mainly caused by OPA1 mutations and is characterized by the degeneration of retinal ganglion cells (RGCs), whose axons form the…”
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Mitochondrial OPA1 Deficiency Is Associated to Reversible Defects in Spatial Memory Related to Adult Neurogenesis in Mice
Published in eNeuro (01-11-2023)“…Abstract Mitochondria are integrative hubs central to cellular adaptive pathways. Such pathways are critical in highly differentiated postmitotic neurons, the…”
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Impact of physical activity on brain oxidative metabolism and intrinsic capacities in young swiss mice fed a high fat diet
Published in Neuropharmacology (15-12-2023)“…Type 2 diabetes and obesity characterized by hallmarks of insulin resistance along with an imbalance in brain oxidative metabolism would impair intrinsic…”
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Correction: OPA1 deficiency impairs oxidative metabolism in cycling cells, underlining a translational approach for degenerative diseases
Published in Disease models & mechanisms (01-04-2024)“…Dominant optic atrophy is an optic neuropathy with varying clinical symptoms and progression. A severe disorder is associated with certain OPA1 mutations and…”
Get full text
Journal Article -
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Mitochondrial OPA1 Deficiency Is Associated to Reversible Defects in Spatial Memory Related to Adult Neurogenesis in Mice
Published in eNeuro (20-11-2023)“…Abstract Mitochondria are integrative hubs central to cellular adaptive pathways. Such pathways are critical in highly differentiated postmitotic neurons, the…”
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Journal Article -
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MSP1P is an intermembrane space dynamin-related protein that mediates mitochondrial fusion in a DNM1P-dependent manner in S.pombe
Published in FEBS letters (2005)“…Mitochondrial morphology is controlled by large GTPases, such as Msp1p, whose action on mitochondrial membranes is not yet understood. The sub-mitochondrial…”
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