Search Results - "Botella, José A"

Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease by Bayersdorfer, Florian, Voigt, Aaron, Schneuwly, Stephan, Botella, José A

“…Abstract Parkinson's disease has been found to be caused by both, genetic and environmental factors. Despite the diversity of causes involved, a convergent…”
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Modelling Parkinson’s Disease in Drosophila by Botella, José A., Bayersdorfer, Florian, Gmeiner, Florian, Schneuwly, Stephan

“…The recent discovery of a number of genes involved in familial forms of Parkinson’s disease (PD) has moved the use of model genetic organisms to the frontline…”
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RasGAP mediates neuronal survival in Drosophila through direct regulation of Rab5-dependent endocytosis by Rowshanravan, Behzad, Woodcock, Simon A, Botella, José A, Kiermayer, Claudia, Schneuwly, Stephan, Hughes, David A

“…The GTPase Ras can either promote or inhibit cell survival. Inactivating mutations in Drosophila RasGAP (encoded by vap), a Ras GTPase-activating protein, lead…”
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Overexpression of human and fly frataxins in Drosophila provokes deleterious effects at biochemical, physiological and developmental levels by Navarro, Juan A, Llorens, José V, Soriano, Sirena, Botella, José A, Schneuwly, Stephan, Martínez-Sebastián, María J, Moltó, María D

“…Friedreich's ataxia (FA), the most frequent form of inherited ataxias in the Caucasian population, is caused by a reduced expression of frataxin, a highly…”
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Analysis of dopaminergic neuronal dysfunction in genetic and toxin‐induced models of Parkinson's disease in Drosophila by Navarro, Juan A., Heßner, Sabina, Yenisetti, Sarat C., Bayersdorfer, Florian, Zhang, Li, Voigt, Aaron, Schneuwly, Stephan, Botella, Jose A.

“…Drosophila melanogaster has contributed significantly to the understanding of disease mechanisms in Parkinson's disease (PD) as it is one of the very few PD…”
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Altered lipid metabolism in a Drosophila model of Friedreich's ataxia by Navarro, Juan A., Ohmann, Elisabeth, Sanchez, Diego, Botella, José A., Liebisch, Gerhard, Moltó, María D., Ganfornina, María D., Schmitz, Gerd, Schneuwly, Stephan

“…Friedreich's ataxia (FRDA) is the most common form of autosomal recessive ataxia caused by a deficit in the mitochondrial protein frataxin. Although…”
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Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease by Botella, Jose A, Bayersdorfer, Florian, Schneuwly, Stephan

“…Abstract Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta . Some of the…”
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Causative role of oxidative stress in a Drosophila model of Friedreich ataxia by Llorens, José V, Navarro, Juan A, Martínez-Sebastián, Maria J, Baylies, Mary K, Schneuwly, S, Botella, José A, Moltó, Maria D

“…Friedreich ataxia (FA), the most common form of hereditary ataxia, is caused by a deficit in the mitochondrial protein frataxin. While several hypotheses have…”
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The Drosophila carbonyl reductase sniffer is an efficient 4-oxonon-2-enal (4ONE) reductase by Martin, Hans-Jörg, Ziemba, Marta, Kisiela, Michael, Botella, José A., Schneuwly, Stephan, Maser, Edmund

“…Studies with the fruit-fly Drosophila melanogaster demonstrated that the enzyme sniffer prevented oxidative stress-induced neurodegeneration. Mutant flies…”
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Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects by Kosmidis, Stylianos, Botella, Jose A, Mandilaras, Konstantinos, Schneuwly, Stephan, Skoulakis, Efthimios M.C, Rouault, Tracey A, Missirlis, Fanis

“…Abstract Cellular and organismal iron storage depends on the function of the ferritin protein complex in insects and mammals alike. In the central nervous…”
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Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia by Kosmidis, Stylianos, Missirlis, Fanis, Botella, Jose A, Schneuwly, Stephan, Rouault, Tracey A, Skoulakis, Efthimios M C

“…Iron is required for organismal growth. Therefore, limiting iron availability may be a key part of the host's innate immune response to various pathogens, for…”
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Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich's ataxia by Navarro, Juan A, Botella, Jose A, Metzendorf, Christoph, Lind, Maria I, Schneuwly, Stephan

“…Friedreich's ataxia is the most important recessive ataxia in the Caucasian population. Loss of frataxin expression affects the production of iron-sulfur…”
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Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap by Botella, José A, Kretzschmar, Doris, Kiermayer, Claudia, Feldmann, Pascale, Hughes, David A, Schneuwly, Stephan

“…Ras signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in…”
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Hyperoxia-induced neurodegeneration as a tool to identify neuroprotective genes in Drosophila melanogaster by Gruenewald, Christoph, Botella, Jose A., Bayersdorfer, Florian, Navarro, Juan A., Schneuwly, Stephan

“…Oxidative stress has been reported to be a common underlying mechanism in the pathogenesis of many neurodegenerative disorders such as Alzheimer, Huntington,…”
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The Drosophila Carbonyl Reductase Sniffer Prevents Oxidative Stress-Induced Neurodegeneration by Botella, Jose A, Ulschmid, Julia K, Gruenewald, Christoph, Moehle, Christoph, Kretzschmar, Doris, Becker, Katja, Schneuwly, Stephan

“…A growing body of evidence suggests that oxidative stress is a common underlying mechanism in the pathogenesis of neurodegenerative disorders such as…”
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A Cluster of Structural and Regulatory Genes for Light‐Induced Carotenogenesis in Myxococcus xanthus by Botella, José A., Murillo, Francisco J., Ruiz‐Vázquez, Rosa

“…In the bacterium Myxococcus xanthus, several genes for carotenoid synthesis lie together at the carA‐carB chromosomal locus and are co‐ordinately activated by…”
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Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich׳s ataxia by Navarro, Juan A., Botella, Jose A., Metzendorf, Christoph, Lind, Maria I., Schneuwly, Stephan

“…Friedreich׳s ataxia is the most important recessive ataxia in the Caucasian population. Loss of frataxin expression affects the production of iron–sulfur…”
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The Drosophila cell shape regulator c-Jun N-terminal kinase also functions as a stress-activated protein kinase by Botella, José A., Baines, Ian A., Williams, Daniel D., Goberdhan, Deborah C.I., Proud, Chris G., Wilson, Clive

“…Mammalian c-Jun N-terminal kinases (JNKs) are members of a group of stress-activated intracellular signalling molecules within the MAP kinase family. Molecular…”
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Deregulation of the Egfr/Ras Signaling Pathway Induces Age-related Brain Degeneration in the iDrosophilaMutant ivap by Botella, Jose A, Kretzschmar, Doris, Kiermayer, Claudia, Feldmann, Pascale, Hughes, David A, Schneuwly, Stephan

“…Ras signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in…”
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Characterisation of Three ACC Synthase Gene Family Members during Post-Harvest-Induced Senescence in Broccoli (Brassica oleracea L var. italica) by Gonzalez, Nelson, Botella, Jose Ramon

“…We investigated the gene expression profiles of different members of the 1-aminocyclopropane-1 -carboxilic acid (ACC) synthase (EC 4.4.1.1 4) gene family in…”
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