Search Results - "Botelho Pereira SOARES, Milena"

Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins by Matutino Bastos, Tanira, Mannochio Russo, Helena, Silvio Moretti, Nilmar, Schenkman, Sergio, Marcourt, Laurence, Gupta, Mahabir Prashad, Wolfender, Jean-Luc, Ferreira Queiroz, Emerson, Botelho Pereira Soares, Milena

“…Benznidazole and nifurtimox, the only drugs available for the treatment of Chagas disease, have limited efficacy and have been associated with severe adverse…”
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Early Transplantation of Bone Marrow Mononuclear Cells Promotes Neuroprotection and Modulation of Inflammation After Status Epilepticus in Mice by Paracrine Mechanisms by Leal, Marcos Maurício Tosta, Costa-Ferro, Zaquer Suzana Munhoz, Souza, Bruno Solano de Freitas, Azevedo, Carine Machado, Carvalho, Thiago Meneses, Kaneto, Carla Martins, Carvalho, Rejane Hughes, dos Santos, Ricardo Ribeiro, Soares, Milena Botelho Pereira

“…Status epilepticus (SE) is a severe clinical manifestation of epilepsy associated with intense neuronal loss and inflammation, two key factors involved in the…”
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Gene Expression Changes Associated with Myocarditis and Fibrosis in Hearts of Mice with Chronic Chagasic Cardiomyopathy by Soares, Milena Botelho Pereira, de Lima, Ricardo Santana, Rocha, Leonardo Lima, Vasconcelos, Juliana Fraga, Rogatto, Silvia Regina, dos Santos, Ricardo Ribeiro, Iacobas, Sanda, Goldenberg, Regina Coeli, Iacobas, Dumitru Andrei, Tanowitz, Herbert Bernard, de Carvalho, Antonio Carlos Campos, Spray, David Conover

“…Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi–infected individuals develop…”
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Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity by Improta Caria, Alex Cleber, Nonaka, Carolina Kymie Vasques, Pereira, Ciro Silveira, Soares, Milena Botelho Pereira, Macambira, Simone Garcia, Souza, Bruno Solano de Freitas

“…MicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally. They are involved in the regulation of physiological processes, such…”
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Fluorescent Canthin‐6‐one Alkaloids from Simaba bahiensis: Isolation, Identification, and Cell‐Labeling Properties by dos Santos Costa, Rafael, do Espírito‐Santo, Renan Fernandes, Abreu, Lucas Silva, de Oliveira Aguiar, Leonardo, Leite Fontes, Dara, Fechine Tavares, Josean, Sobral da Silva, Marcelo, Botelho Pereira Soares, Milena, da Silva Velozo, Eudes, Flora Villarreal, Cristiane

“…Canthin‐6‐one alkaloids, which are present in plants of the genus Simaba, are natural compounds that are capable of acting as fluorescent probes. However, the…”
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Current Clinical Landscape and Global Potential of Bacteriophage Therapy by Hitchcock, Nicole Marie, Devequi Gomes Nunes, Danielle, Shiach, Job, Valeria Saraiva Hodel, Katharine, Dantas Viana Barbosa, Josiane, Alencar Pereira Rodrigues, Leticia, Coler, Brahm Seymour, Botelho Pereira Soares, Milena, Badaró, Roberto

“…In response to the global spread of antimicrobial resistance, there is an increased demand for novel and innovative antimicrobials. Bacteriophages have been…”
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A ruthenium-based 5-fluorouracil complex with enhanced cytotoxicity and apoptosis induction action in HCT116 cells by Silva, Valdenizia Rodrigues, Corrêa, Rodrigo S., Santos, Luciano de Souza, Soares, Milena Botelho Pereira, Batista, Alzir Azevedo, Bezerra, Daniel Pereira

“…Combination of multifunctionalities into one compound is a rational strategy in medicinal chemical design, and have often been used with metallodrug-based…”
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The Main Molecular and Serological Methods for Diagnosing COVID-19: An Overview Based on the Literature by Machado, Bruna Aparecida Souza, Hodel, Katharine Valéria Saraiva, Barbosa-Júnior, Valdir Gomes, Soares, Milena Botelho Pereira, Badaró, Roberto

“…Diagnostic tests have been considered as the main alternative for the control of coronavirus disease (COVID-19), caused by the severe acute respiratory…”
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Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades by Evangelista, Afrânio Ferreira, Vannier-Santos, Marcos André, de Assis Silva, Gessica Sabrina, Silva, Daniela Nascimento, Juiz, Paulo José Lima, Nonaka, Carolina Kymie Vasques, Dos Santos, Ricardo Ribeiro, Soares, Milena Botelho Pereira, Villarreal, Cristiane Flora

“…Diabetic neuropathy (DN) is a frequent and debilitating manifestation of diabetes mellitus, to which there are no effective therapeutic approaches. Mesenchymal…”
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Distribution and proliferation of bone marrow cells in the brain after pilocarpine‐induced status epilepticus in mice by Longo, Beatriz, Romariz, Simone, Blanco, Miriam Marcela, Vasconcelos, Juliana Fraga, Bahia, Luciana, Soares, Milena Botelho Pereira, Mello, Luiz E., Ribeiro‐dos‐Santos, Ricardo

“…Summary The distribution of bone marrow cells in brain areas during the acute period after pilocarpine‐induced status epilepticus (SE) was investigated here…”
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Unveiling Targets for Treating Postoperative Pain: The Role of the TNF-α/p38 MAPK/NF-κB/Nav1.8 and Nav1.9 Pathways in the Mouse Model of Incisional Pain by de Lima, Flávia Oliveira, Lauria, Pedro Santana Sales, do Espírito-Santo, Renan Fernandes, Evangelista, Afrânio Ferreira, Nogueira, Tâmara Magalhães Oliveira, Araldi, Dionéia, Soares, Milena Botelho Pereira, Villarreal, Cristiane Flora

“…Although the mouse model of incisional pain is broadly used, the mechanisms underlying plantar incision-induced nociception are not fully understood. This work…”
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Leishmania dual‐specificity tyrosine‐regulated kinase 1 (DYRK1) is required for sustaining Leishmania stationary phase phenotype by Rocha, Vinícius Pinto Costa, Dacher, Mariko, Young, Simon Alan, Kolokousi, Foteini, Efstathiou, Antonia, Späth, Gerald Frank, Soares, Milena Botelho Pereira, Smirlis, Despina

“…Although the multiplicative and growth‐arrested states play key roles in Leishmania development, the regulators of these transitions are largely unknown. In an…”
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Cytotoxic and Antifungal Amides Derived from Ferulic Acid: Molecular Docking and Mechanism of Action by de Morais, Mayara Castro, Perez-Castillo, Yunierkis, Silva, Valdenizia Rodrigues, Santos, Luciano de Souza, Soares, Milena Botelho Pereira, Bezerra, Daniel Pereira, de Castro, Ricardo Dias, de Sousa, Damião Pergentino

“…Amides derived from ferulic acid have a wide spectrum of pharmacological activities, including antitumor and antifungal activity. In the present study, a…”
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Conditioned Medium of Bone Marrow-Derived Mesenchymal Stromal Cells as a Therapeutic Approach to Neuropathic Pain: A Preclinical Evaluation by Villarreal, Cristiane Flora, Ribeiro-dos-Santos, Ricardo, de Alcântara, Adriano Costa, Silva, Daniela Nascimento, Evangelista, Afrânio Ferreira, Santos, Dourivaldo Silva, Gama, Kelly Barbosa, Soares, Milena Botelho

“…Neuropathic pain is a type of chronic pain caused by injury or dysfunction of the nervous system, without effective therapeutic approaches. Mesenchymal stromal…”
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Association of Cardiac Galectin-3 Expression, Myocarditis, and Fibrosis in Chronic Chagas Disease Cardiomyopathy by de Freitas Souza, Bruno Solano, Silva, Daniela Nascimento, Carvalho, Rejane Hughes, de Almeida Sampaio, Gabriela Louise, Paredes, Bruno Diaz, Aragão França, Luciana, Azevedo, Carine Machado, Vasconcelos, Juliana Fraga, Meira, Cassio Santana, Neto, Paulo Chenaud, Macambira, Simone Garcia, da Silva, Kátia Nunes, Allahdadi, Kyan James, Tavora, Fabio, de Souza Neto, João David, dos Santos, Ricardo Ribeiro, Soares, Milena Botelho Pereira

“…Chronic Chagas disease cardiomyopathy, caused by Trypanosoma cruzi infection, is a major cause of heart failure in Latin America. Galectin-3 (Gal-3) has been…”
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Potent anti-inflammatory activity of betulinic acid treatment in a model of lethal endotoxemia by Oliveira Costa, José Fernando, Barbosa-Filho, José Maria, de Azevedo Maia, Gabriela Lemos, Guimarães, Elisalva Teixeira, Meira, Cássio Santana, Ribeiro-dos-Santos, Ricardo, Pontes de Carvalho, Lain Carlos, Soares, Milena Botelho Pereira

“…Betulinic acid (BA) is a lupane-type triterpene with a number of biological activities already reported. While potent anti-HIV and antitumoral activities were…”
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Structural design, synthesis and pharmacological evaluation of 4-thiazolidinones against Trypanosoma cruzi by de Oliveira Filho, Gevanio Bezerra, de Oliveira Cardoso, Marcos Veríssimo, Espíndola, José Wanderlan Pontes, Ferreira, Luiz Felipe Gomes Rebello, de Simone, Carlos Alberto, Ferreira, Rafaela Salgado, Coelho, Pollyanne Lacerda, Meira, Cássio Santana, Magalhaes Moreira, Diogo Rodrigo, Soares, Milena Botelho Pereira, Lima Leite, Ana Cristina

“…[Display omitted] Chagas disease is an infection caused by protozoan Trypanosoma cruzi, which affects approximately 8–10million people worldwide. Benznidazole…”
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GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells by Bacelar Sacramento de Araújo, Taís, de Oliveira Siquara da Rocha, Leonardo, Torres Andion Vidal, Manuela, Cerqueira Coelho, Paulo Lucas, Galvão Dos Reis, Mitermayer, Solano de Freitas Souza, Bruno, Botelho Pereira Soares, Milena, Almeida Pereira, Thiago, Della Coletta, Ricardo, Pereira Bezerra, Daniel, Borges Dias, Rosane, Araújo Gurgel Rocha, Clarissa

“…Due to its importance in the pathogenesis of oral squamous cell carcinoma (OSCC), the Hedgehog (HH) pathway is considered a potential therapeutic target. We…”
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The protective effect of solidagenone from Solidago chilensis Meyen in a mouse model of airway inflammation by Vasconcelos, Juliana Fraga, Santos, Ivanilson Pimenta, Oliveira, Temistocles Barroso, Kelly, Andressa Maia, Reis, Bruna Padilha Zurita Claro, Orge, Iasmim Diniz, Meira, Cássio Santana, Valverde, Simone Sacramento, Soares, Milena Botelho Pereira

“…Solidagenone is the main active constituent present in Solidago chilensis Meyen which is used in folk medicine to treat pain and inflammatory diseases. This…”
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Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes by Matutino Bastos, Tanira, Botelho Pereira Soares, Milena, Haddad Franco, Caio, Alcântara, Laura, Antonini, Lorenzo, Sabatino, Manuela, Mautone, Nicola, Holanda Freitas-Junior, Lucio, Moraes, Carolina Borsoi, Ragno, Rino, Rotili, Dante, Schenkman, Sergio, Mai, Antonello, Silvio Moretti, Nilmar

“…Chagas disease is an illness caused by the protozoan parasite , affecting more than 7 million people in the world. Benznidazole and nifurtimox are the only…”
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