Search Results - "Botchwey, Edward"

Monocytes and macrophages in tissue repair: Implications for immunoregenerative biomaterial design by Ogle, Molly E, Segar, Claire E, Sridhar, Sraeyes, Botchwey, Edward A

“…Monocytes and macrophages play a critical role in tissue development, homeostasis, and injury repair. These innate immune cells participate in guiding vascular…”
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Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities by Clark, Amy Y., Martin, Karen E., García, José R., Johnson, Christopher T., Theriault, Hannah S., Han, Woojin M., Zhou, Dennis W., Botchwey, Edward A., García, Andrés J.

“…Stem cell therapies are limited by poor cell survival and engraftment. A hurdle to the use of materials for cell delivery is the lack of understanding of…”
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Sickle cell disease as an accelerated aging syndrome by Idris, Ibrahim M, Botchwey, Edward A, Hyacinth, Hyacinth I

“…Sickle cell disease (SCD) is characterized by vaso-occlusion, hemolysis, and systemic manifestations that form the hallmark of the disease. Apart from…”
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Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury by Olingy, Claire E., San Emeterio, Cheryl L., Ogle, Molly E., Krieger, Jack R., Bruce, Anthony C., Pfau, David D., Jordan, Brett T., Peirce, Shayn M., Botchwey, Edward A.

“…Successful tissue repair requires the activities of myeloid cells such as monocytes and macrophages that guide the progression of inflammation and healing…”
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Xylan hemicellulose improves chitosan hydrogel for bone tissue regeneration by Bush, Joshua R., Liang, Haixiang, Dickinson, Molly, Botchwey, Edward A.

“…The hemicellulose xylan, which has immunomodulatory effects, has been combined with chitosan to form a composite hydrogel to improve the healing of bone…”
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Selective recruitment of non-classical monocytes promotes skeletal muscle repair by San Emeterio, Cheryl L, Olingy, Claire E, Chu, Yihsuan, Botchwey, Edward A

“…Abstract Regeneration of traumatic defects in skeletal muscle requires the synchronized behavior of multiple cells that participate in repair. The inflammatory…”
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The promotion of mandibular defect healing by the targeting of S1P receptors and the recruitment of alternatively activated macrophages by Das, Anusuya, Segar, Claire E, Hughley, Brian B, Bowers, Daniel T, Botchwey, Edward A

“…Abstract Endogenous signals originating at the site of injury are involved in the paracrine recruitment, proliferation, and differentiation of circulating…”
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Financial inclusion and human development in frontier countries by Ofosu‐Mensah Ababio, Josephine, Attah‐Botchwey, Edward, Osei‐Assibey, Eric, Barnor, Charles

“…This study empirically investigates whether the level of human development drives greater financial inclusion, and vice versa in the contexts of frontier…”
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Delivery of bioactive lipids from composite microgel-microsphere injectable scaffolds enhances stem cell recruitment and skeletal repair by Das, Anusuya, Barker, Daniel A, Wang, Tiffany, Lau, Cheryl M, Lin, Yong, Botchwey, Edward A

“…In this study, a microgel composed of chitosan and inorganic phosphates was used to deliver poly(lactic-co-glycolic acid) (PLAGA) microspheres loaded with…”
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Dual delivery of IL-10 and AT-RvD1 from PEG hydrogels polarize immune cells towards pro-regenerative phenotypes by Sok, Mary Caitlin P., Baker, Nusaiba, McClain, Claire, Lim, Hong Seo, Turner, Thomas, Hymel, Lauren, Ogle, Molly, Olingy, Claire, Palacios, Joshua I., Garcia, José R., Srithar, Krithik, García, Andrés J., Qiu, Peng, Botchwey, Edward A.

“…Inflammation after traumatic injury or surgical intervention is both a protective tissue response leading to regeneration and a potential cause of wound…”
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Regulation of angiogenesis and bone regeneration with natural and synthetic small molecules by Segar, Claire E, Ogle, Molly E, Botchwey, Edward A

“…Regeneration of bone requires the coordinated processes of angiogenesis and osteogenesis. These repair mechanisms are closely linked through both direct…”
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Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD by Awojoodu, Anthony O., Keegan, Philip M., Lane, Alicia R., Zhang, Yuying, Lynch, Kevin R., Platt, Manu O., Botchwey, Edward A.

“…Sphingolipids are a class of lipids containing a backbone of sphingoid bases that can be produced de novo through the reaction of palmitate and serine and…”
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Improving hard palate wound healing using immune modulatory autotherapies by Ballestas, Samir A., Turner, Thomas C., Kamalakar, Archana, Stephenson, Yvonne C., Willett, Nick J., Goudy, Steven L., Botchwey, Edward A.

“…[Display omitted] Oral cavity wound healing occurs in an environment that sustains ongoing physical trauma and is rich in bacteria. Despite this, injuries to…”
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Emerging Ideas: Treatment of Precollapse Osteonecrosis Using Stem Cells and Growth Factors by Cui, Quanjun, Botchwey, Edward A.

“…Background Osteonecrosis (ON) of the femoral head is a devastating disease affecting young patients at their most productive age, causing major socioeconomic…”
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Enrichment of endogenous fractalkine and anti-inflammatory cells via aptamer-functionalized hydrogels by Enam, Syed Faaiz, Krieger, Jack R., Saxena, Tarun, Watts, Brian E., Olingy, Claire E., Botchwey, Edward A., Bellamkonda, Ravi V.

“…Early recruitment of non-classical monocytes and their macrophage derivatives is associated with augmented tissue repair and improved integration of…”
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Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations by Medrano-Trochez, Camila, Chatterjee, Paramita, Pradhan, Pallab, Stevens, Hazel Y, Ogle, Molly E, Botchwey, Edward A, Kurtzberg, Joanne, Yeago, Carolyn, Gibson, Greg, Roy, Krishnendu

“…Human Mesenchymal stromal cells (hMSCs) from various tissue sources are widely investigated in clinical trials. These MSCs are often administered to patients…”
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Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis by Awojoodu, Anthony O., Ogle, Molly E., Sefcik, Lauren S., Bowers, Daniel T., Martin, Kyle, Brayman, Kenneth L., Lynch, Kevin R., Peirce-Cottler, Shayn M., Botchwey, Edward

“…Endothelial cells play significant roles in conditioning tissues after injury by the production and secretion of angiocrine factors. At least two distinct…”
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Aspirin-Triggered Resolvin D1-modified materials promote the accumulation of pro-regenerative immune cell subsets and enhance vascular remodeling by Sok, Mary Caitlin P., Tria, Maxianne C., Olingy, Claire E., San Emeterio, Cheryl L., Botchwey, Edward A.

“…[Display omitted] Many goals in tissue engineering rely on modulating cellular localization and polarization of cell signaling, including the inhibition of…”
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Determination of a Critical Size Threshold for Volumetric Muscle Loss in the Mouse Quadriceps by Anderson, Shannon E, Han, Woojin M, Srinivasa, Vunya, Mohiuddin, Mahir, Ruehle, Marissa A, Moon, June Young, Shin, Eunjung, San Emeterio, Cheryl L, Ogle, Molly E, Botchwey, Edward A, Willett, Nick J, Jang, Young C

“…The goal of this study was to determine the threshold for a critically sized, nonhealing muscle defect by characterizing key components in the balance between…”
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Bone Marrow Mobilization and Local Stromal Cell-Derived Factor-1α Delivery Enhances Nascent Supraspinatus Muscle Fiber Growth by Anderson, Leah E, Tellier, Liane E, Shah, Keshav R, Pearson, Joseph J, Brimeyer, Alexandra L, Botchwey, Edward A, Temenoff, Johnna S

“…Rotator cuff tear is a significant problem that leads to poor clinical outcomes due to muscle degeneration after injury. The objective of this study was to…”
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