Search Results - "Botchkarev, Vladimir V"

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage by Vohhodina, Jekaterina, Goehring, Liana J., Liu, Ben, Kong, Qing, Botchkarev Jr, Vladimir V., Huynh, Mai, Liu, Zhiqi, Abderazzaq, Fieda O., Clark, Allison P., Ficarro, Scott B., Marto, Jarrod A., Hatchi, Elodie, Livingston, David M.

“…R-loop structures act as modulators of physiological processes such as transcription termination, gene regulation, and DNA repair. However, they can cause…”
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Functions and regulation of the Polo-like kinase Cdc5 in the absence and presence of DNA damage by Botchkarev, Vladimir V., Haber, James E.

“…Polo-like kinases are essential cell cycle regulators that are conserved from yeast to humans. Unlike higher eukaryotes, who express multiple Polo-like kinase…”
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RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci by Vohhodina, Jekaterina, Toomire, Kimberly J., Petit, Sarah A., Micevic, Goran, Kumari, Geeta, Botchkarev, Vladimir V., Li, Zhe, Livingston, David M., Hu, Yiduo

“…BRCA1 promotes error-free, homologous recombination-mediated repair (HRR) of DNA double-stranded breaks (DSBs). When excessive and uncontrolled, BRCA1 HRR…”
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Three-dimensional structure of the radial spokes reveals heterogeneity and interactions with dyneins in Chlamydomonas flagella by Barber, Cynthia F, Heuser, Thomas, Carbajal-González, Blanca I, Botchkarev, Jr, Vladimir V, Nicastro, Daniela

“…Radial spokes (RSs) play an essential role in the regulation of axonemal dynein activity and thus of ciliary and flagellar motility. However, few details are…”
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The budding yeast Polo-like kinase localizes to distinct populations at centrosomes during mitosis by Botchkarev, Jr, Vladimir V, Garabedian, Mikael V, Lemos, Brenda, Paulissen, Eric, Haber, James E

“…The budding yeast Polo-like kinase Cdc5 is a key regulator of many mitotic events. Cdc5 coordinates its functions spatially and temporally by changing its…”
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The budding yeast Polo-like kinase Cdc5 is released from the nucleus during anaphase for timely mitotic exit by Botchkarev, Vladimir V, Rossio, Valentina, Yoshida, Satoshi

“…Polo-like kinases are important regulators of multiple mitotic events; however, how Polo-like kinases are spatially and temporally regulated to perform their…”
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Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer by Wang, Hua, Xiang, Dongxi, Liu, Ben, He, Aina, Randle, Helena J., Zhang, Kelvin Xi, Dongre, Anushka, Sachs, Norman, Clark, Allison P., Tao, Luwei, Chen, Qing, Botchkarev, Vladimir V., Xie, Ying, Dai, Ning, Clevers, Hans, Li, Zhe, Livingston, David M.

“…Loss of BRCA1 p220 function often results in basal-like breast cancer (BLBC), but the underlying disease mechanism is largely opaque. In mammary epithelial…”
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BMP Signaling Induces Cell-Type-Specific Changes in Gene Expression Programs of Human Keratinocytes and Fibroblasts by Fessing, Michael Y., Atoyan, Ruzanna, Shander, Ben, Mardaryev, Andrei N., Botchkarev, Vladimir V., Poterlowicz, Krzysztof, Peng, Yonghong, Efimova, Tatiana, Botchkarev, Vladimir A.

“…BMP signaling has a crucial role in skin development and homeostasis, whereas molecular mechanisms underlying its involvement in regulating gene expression…”
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Efficient and Specific In Vivo Genetic Engineering of Human Hematopoietic Stem Progenitor Cells without Selective Conditioning by Botchkarev, Vladimir V, Harrington, Sean, Justen, Alexander, Kimber, Casey, Kapuria, Anjali, Xu, Yuanxin, Haugh, Kelsey, Ankala, Ramya, Kipniss, Nathan, de Jesus, Rowena, Adewale, Funmi, Daniels, Kathy, Crocker, Samantha, Liang, Anna, Joyce, Shannon, Smith, Derek, Wong, Athena, Berlfein, Valeria, Amatya, Shirisha, Cruite, Patricia, Usmani, Shariq, Ruzo, Albert, Ferland, Benjamin, Chandra, Sundeep, Stoppato, Matteo, Trudeau, Kyle, Rebar, Edward, Shah, Jagesh, Biasco, Luca

“…Achieving in vivo genetic engineering of hematopoietic stem progenitor cells (HSPC) has the potential to transform treatment for hematological disorders. An…”
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