Search Results - "Botchan, M"

The minichromosome maintenance replicative helicase by Bell, Stephen D, Botchan, Michael R

“…The eukaryotic replicative helicase, the minichromosome maintenance (MCM) complex, is composed of six distinct, but related, subunits MCM(2-7). The…”
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Orc mutants arrest in metaphase with abnormally condensed chromosomes by Pflumm, M F, Botchan, M R

“…The origin recognition complex (ORC) is a six subunit complex required for eukaryotic DNA replication initiation and for silencing of the heterochromatic…”
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DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC-DNA binding by Remus, Dirk, Beall, Eileen L, Botchan, Michael R

“…Drosophila origin recognition complex (ORC) localizes to defined positions on chromosomes, and in follicle cells the chorion gene amplification loci are…”
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Functional Analysis of Mutant and Wild-Type Drosophila Origin Recognition Complex by Chesnokov, Igor, Remus, Dirk, Botchan, Michael

“…The origin recognition complex (ORC) is the DNA replication initiator protein in eukaryotes. We have reconstituted a functional recombinant Drosophila ORC and…”
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The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication by Li, R, Botchan, M R

“…For papillomavirus DNA replication, the E2 enhancer protein cooperatively assists in binding of the E1 helicase to the origin. We report that, at limiting E1…”
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Assembly of functionally active Drosophila origin recognition complex from recombinant proteins by Chesnokov, I, Gossen, M, Remus, D, Botchan, M

“…In eukaryotes the sites for the initiation of chromosomal DNA replication are believed to be determined in part by the binding of a heteromeric origin…”
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Role for a Drosophila Myb-containing protein complex in site-specific DNA replication by Botchan, Michael R, Beall, Eileen L, Manak, J. Robert, Zhou, Sharleen, Bell, Maren, Lipsick, Joseph S

“…There is considerable interest in the developmental, temporal and tissue-specific patterns of DNA replication in metazoans. Site-specific DNA replication at…”
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The retinoblastoma gene product regulates Sp1-mediated transcription by Kim, S J, Onwuta, U S, Lee, Y I, Li, R, Botchan, M R, Robbins, P D

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Crystal Structure of the Human Papillomavirus Type 18 E2 Activation Domain by Harris, Seth F., Botchan, Michael R.

“…The papillomavirus E2 protein regulates viral transcription and DNA replication through interactions with cellular and viral proteins. The amino-terminal…”
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Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes by Pak, D T, Pflumm, M, Chesnokov, I, Huang, D W, Kellum, R, Marr, J, Romanowski, P, Botchan, M R

“…The origin recognition complex (ORC) is required to initiate eukaryotic DNA replication and also engages in transcriptional silencing in S. cerevisiae. We…”
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Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription by Li, R, Knight, J D, Jackson, S P, Tjian, R, Botchan, M R

“…The physical interaction of heterologous site-specific DNA-binding proteins is an important theme in eukaryotic transcriptional regulation. In this paper, we…”
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Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator by Mohr, I.J. (University of California, Berkely, CA), Clark, R, Sun, S, Androphy, E.J, MacPherson, P, Botchan, M.R

“…The mechanism by which transcription factors stimulate DNA replication in eukaryotes is unknown. Bovine papillomavirus DNA synthesis requires the products of…”
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Coordinating DNA Replication with Cell Division: Current Status of the Licensing Concept by Botchan, Michael

“…Botchan considers the DNA replication "licensing" hypothesis. The actual mechanisms of DNA replication per se may be highly conserved, but the biochemical…”
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Acidic transcription factors alleviate nucleosome-mediated repression of DNA replication of bovine papillomavirus type 1 by Li, R, Botchan, M.R

“…The papillomavirus E2 transcription factor is directly involved in viral DNA replication. Previous studies have shown that E2 interacts with both the viral E1…”
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A Drosophila Homolog of the Yeast Origin Recognition Complex by Gossen, Manfred, Daniel T. S. Pak, Hansen, Stig K., Acharya, Jairaj K., Botchan, Michael R.

“…Genes for Drosophila melanogaster have been identified that encode proteins homologous to Orc2p and Orc5p of the Saccharomyces cerevisiae origin recognition…”
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The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase by Yang, L, Mohr, I, Fouts, E, Lim, D.A, Nohaile, M, Botchan, M

“…For efficient DNA replication of papillomaviruses, only two viral-encoded proteins, E1 and E2, are required. Other proteins and factors are provided by the…”
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p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner by Chesnokov, Igor, Chu, Wen-Ming, Botchan, Michael R., Schmid, Carl W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Cellular DNA Polymerase α-Primase is Required for Papillomavirus DNA Replication and Associates with the Viral E1 Helicase by Park, Peter, Copeland, William, Yang, Liu, Wang, Teresa, Botchan, Michael R., Mohr, Ian J.

“…Persistent infection by papillomaviruses involves the maintenance of viral DNA as a nuclear plasmid, the replication of which requires host DNA polymerases…”
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Segregation of Viral Plasmids Depends on Tethering to Chromosomes and is Regulated by Phosphorylation by Lehman, Chris W., Botchan, Michael R.

“…Eukaryotic viruses can maintain latency in dividing cells as extrachromosomal nuclear plasmids. Segregation and nuclear retention of DNA is, therefore, a key…”
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Activation of BPV-1 replication in vitro by the transcription factor E2 by Yang, Liu, Li, Rong, Mohr, Ian J, Clark, Robin, Botchan, Michael R

“…Soluble extracts from uninfected murine cells supplemented with purified viral E1 and E2 proteins support the replication of exogenously added papilloma virus…”
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