Search Results - "Bot, Brian"

Remote smartphone monitoring of Parkinson’s disease and individual response to therapy by Omberg, Larsson, Chaibub Neto, Elias, Perumal, Thanneer M., Pratap, Abhishek, Tediarjo, Aryton, Adams, Jamie, Bloem, Bastiaan R., Bot, Brian M., Elson, Molly, Goldman, Samuel M., Kellen, Michael R., Kieburtz, Karl, Klein, Arno, Little, Max A., Schneider, Ruth, Suver, Christine, Tarolli, Christopher, Tanner, Caroline M., Trister, Andrew D., Wilbanks, John, Dorsey, E. Ray, Mangravite, Lara M.

“…Remote health assessments that gather real-world data (RWD) outside clinic settings require a clear understanding of appropriate methods for data collection,…”
Get full text

The consensus molecular subtypes of colorectal cancer by Guinney, Justin, Dienstmann, Rodrigo, Wang, Xin, de Reyniès, Aurélien, Schlicker, Andreas, Soneson, Charlotte, Marisa, Laetitia, Roepman, Paul, Nyamundanda, Gift, Angelino, Paolo, Bot, Brian M, Morris, Jeffrey S, Simon, Iris M, Gerster, Sarah, Fessler, Evelyn, De Sousa E Melo, Felipe, Missiaglia, Edoardo, Ramay, Hena, Barras, David, Homicsko, Krisztian, Maru, Dipen, Manyam, Ganiraju C, Broom, Bradley, Boige, Valerie, Perez-Villamil, Beatriz, Laderas, Ted, Salazar, Ramon, Gray, Joe W, Hanahan, Douglas, Tabernero, Josep, Bernards, Rene, Friend, Stephen H, Laurent-Puig, Pierre, Medema, Jan Paul, Sadanandam, Anguraj, Wessels, Lodewyk, Delorenzi, Mauro, Kopetz, Scott, Vermeulen, Louis, Tejpar, Sabine

“…An international consortium of colorectal cancer researchers undertakes a large-scale data sharing project to achieve a consensus molecular classification of…”
Get full text

The mPower study, Parkinson disease mobile data collected using ResearchKit by Bot, Brian M., Suver, Christine, Neto, Elias Chaibub, Kellen, Michael, Klein, Arno, Bare, Christopher, Doerr, Megan, Pratap, Abhishek, Wilbanks, John, Dorsey, E. Ray, Friend, Stephen H., Trister, Andrew D.

“…Current measures of health and disease are often insensitive, episodic, and subjective. Further, these measures generally are not designed to provide…”
Get full text

Molecular Markers Identify Subtypes of Stage III Colon Cancer Associated With Patient Outcomes by Sinicrope, Frank A, Shi, Qian, Smyrk, Thomas C, Thibodeau, Stephen N, Dienstmann, Rodrigo, Guinney, Justin, Bot, Brian M, Tejpar, Sabine, Delorenzi, Mauro, Goldberg, Richard M, Mahoney, Michelle, Sargent, Daniel J, Alberts, Steven R

“…Background & Aims Categorization of colon cancers into distinct subtypes using a combination of pathway-based biomarkers could provide insight into…”
Get full text

Disentangling personalized treatment effects from “time-of-the-day” confounding in mobile health studies by Chaibub Neto, Elias, Perumal, Thanneer M, Pratap, Abhishek, Tediarjo, Aryton, Bot, Brian M, Mangravite, Lara, Omberg, Larsson

“…Ideally, a patient’s response to medication can be monitored by measuring changes in performance of some activity. In observational studies, however, any…”
Get full text

Database of genomic biomarkers for cancer drugs and clinical targetability in solid tumors by Dienstmann, Rodrigo, Jang, In Sock, Bot, Brian, Friend, Stephen, Guinney, Justin

“…Comprehensive genomic profiling is expected to revolutionize cancer therapy. In this Prospective, we present the prevalence of mutations and copy-number…”
Get more information

Tumor Growth Rate Is an Early Indicator of Antitumor Drug Activity in Phase I Clinical Trials by FERTE, Charles, FERNANDEZ, Marianna, AMMARI, Samy, SORIA, Jean-Charles, HOLLEBECQUE, Antoine, KOSCIELNY, Serge, LEVY, Antonin, MASSARD, Christophe, BALHEDA, Rastislav, BOT, Brian, GOMEZ-ROCA, Carlos, DROMAIN, Clarisse

“…Response Evaluation Criteria in Solid Tumors (RECIST) evaluation does not take into account the pretreatment tumor kinetics and may provide incomplete…”
Get full text

Mobile health: the power of wearables, sensors, and apps to transform clinical trials by Munos, Bernard, Baker, Pamela C., Bot, Brian M., Crouthamel, Michelle, de Vries, Glen, Ferguson, Ian, Hixson, John D., Malek, Linda A., Mastrototaro, John J., Misra, Veena, Ozcan, Aydogan, Sacks, Leonard, Wang, Pei

“…Mobile technology has become a ubiquitous part of everyday life, and the practical utility of mobile devices for improving human health is only now being…”
Get full text

Assessment of the All of Us research program's informed consent process by Doerr, Megan, Moore, Sarah, Barone, Vanessa, Sutherland, Scott, Bot, Brian M., Suver, Christine, Wilbanks, John

“…Informed consent is the gateway to research participation. We report on the results of the formative evaluation that follows the electronic informed consent…”
Get full text

Detecting the impact of subject characteristics on machine learning-based diagnostic applications by Chaibub Neto, Elias, Pratap, Abhishek, Perumal, Thanneer M., Tummalacherla, Meghasyam, Snyder, Phil, Bot, Brian M., Trister, Andrew D., Friend, Stephen H., Mangravite, Lara, Omberg, Larsson

“…Collection of high-dimensional, longitudinal digital health data has the potential to support a wide-variety of research and clinical applications including…”
Get full text

Comparison of Outcomes After Fluorouracil-Based Adjuvant Therapy for Stages II and III Colon Cancer Between 1978 to 1995 and 1996 to 2007: Evidence of Stage Migration From the ACCENT Database by QIAN SHI, ANDRE, Thierry, O'CONNELL, Michael J, SARGENT, Daniel J, GROTHEY, Axel, YOTHERS, Greg, HAMILTON, Stanley R, BOT, Brian M, HALLER, Daniel G, VAN CUTSEM, Eric, TWELVES, Chris, BENEDETTI, Jacqueline K

“…With improved patient care, better diagnosis, and more treatment options after tumor recurrence, outcomes after fluorouracil (FU) -based treatment are expected…”
Get full text

Pooled Safety and Efficacy Analysis Examining the Effect of Performance Status on Outcomes in Nine First-Line Treatment Trials Using Individual Data From Patients With Metastatic Colorectal Cancer by SARGENT, Daniel J, KÖHNE, Claus Henning, DOUILLARD, Jean-Yves, STEPHENS, Richard J, GROTHEY, Axel, GOLDBERG, Richard M, SANOFF, Hanna Kelly, BOT, Brian M, SEYMOUR, Matthew T, DE GRAMONT, Aimery, PORSCHEN, Ranier, SALTZ, Leonard B, ROUGIER, Philippe, TOURNIGAND, Christopher

“…Performance status (PS) is a prognostic factor in patients with metastatic colorectal cancer. Clinical trials typically enroll less than 10% of patients with a…”
Get full text

Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination by Haralambieva, Iana H, Oberg, Ann L, Ovsyannikova, Inna G, Kennedy, Richard B, Grill, Diane E, Middha, Sumit, Bot, Brian M, Wang, Vivian W, Smith, David I, Jacobson, Robert M, Poland, Gregory A

“…Immune responses to current rubella vaccines demonstrate significant inter-individual variability. We performed mRNA-Seq profiling on PBMCs from high and low…”
Get full text

The Mole Mapper Study, mobile phone skin imaging and melanoma risk data collected using ResearchKit by Webster, Dan E., Suver, Christine, Doerr, Megan, Mounts, Erin, Domenico, Lisa, Petrie, Tracy, Leachman, Sancy A., Trister, Andrew D., Bot, Brian M.

“…Sensor-embedded phones are an emerging facilitator for participant-driven research studies. Skin cancer research is particularly amenable to this approach, as…”
Get full text

Physical activity, sleep and cardiovascular health data for 50,000 individuals from the MyHeart Counts Study by Hershman, Steven G., Bot, Brian M., Shcherbina, Anna, Doerr, Megan, Moayedi, Yasbanoo, Pavlovic, Aleksandra, Waggott, Daryl, Cho, Mildred K., Rosenberger, Mary E., Haskell, William L., Myers, Jonathan, Champagne, Mary Ann, Mignot, Emmanuel, Salvi, Dario, Landray, Martin, Tarassenko, Lionel, Harrington, Robert A., Yeung, Alan C., McConnell, Michael V., Ashley, Euan A.

“…Studies have established the importance of physical activity and fitness for long-term cardiovascular health, yet limited data exist on the association between…”
Get full text

Integrated analysis of gene expression, CpG island methylation, and gene copy number in breast cancer cells by deep sequencing by Sun, Zhifu, Asmann, Yan W, Kalari, Krishna R, Bot, Brian, Eckel-Passow, Jeanette E, Baker, Tiffany R, Carr, Jennifer M, Khrebtukova, Irina, Luo, Shujun, Zhang, Lu, Schroth, Gary P, Perez, Edith A, Thompson, E Aubrey

“…We used deep sequencing technology to profile the transcriptome, gene copy number, and CpG island methylation status simultaneously in eight commonly used…”
Get full text

rCGH: a comprehensive array-based genomic profile platform for precision medicine by Commo, Frederic, Guinney, Justin, Ferté, Charles, Bot, Brian, Lefebvre, Celine, Soria, Jean-Charles, André, Fabrice

“…We present rCGH, a comprehensive array-based comparative genomic hybridization analysis workflow, integrating computational improvements and functionalities…”
Get full text

Impact of Young Age on Treatment Efficacy and Safety in Advanced Colorectal Cancer: A Pooled Analysis of Patients From Nine First-Line Phase III Chemotherapy Trials by BLANKE, Charles D, BOT, Brian M, THOMAS, David M, BLEYER, Archie, KOHNE, Claus-Henning, SEYMOUR, Matthew T, DE GRAMONT, Aimery, GOLDBERG, Richard M, SARGENT, Daniel J

“…Colorectal cancer predominantly occurs in the elderly, but approximately 5% of patients are 50 years old or younger. We sought to determine whether young age…”
Get full text

Formative Evaluation of Participant Experience With Mobile eConsent in the App-Mediated Parkinson mPower Study: A Mixed Methods Study by Doerr, Megan, Maguire Truong, Amy, Bot, Brian M, Wilbanks, John, Suver, Christine, Mangravite, Lara M

“…To fully capitalize on the promise of mobile technology to enable scalable, participant-centered research, we must develop companion self-administered…”
Get full text

A large dataset of protein dynamics in the mammalian heart proteome by Lau, Edward, Cao, Quan, Ng, Dominic C.M., Bleakley, Brian J., Dincer, T. Umut, Bot, Brian M., Wang, Ding, Liem, David A., Lam, Maggie P.Y., Ge, Junbo, Ping, Peipei

“…Protein stability is a major regulatory principle of protein function and cellular homeostasis. Despite limited understanding on mechanisms, disruption of…”
Get full text