Search Results - "Boswell, H Scott"

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway by Chen, Sisi, Wang, Qiang, Yu, Hao, Capitano, Maegan L., Vemula, Sasidhar, Nabinger, Sarah C., Gao, Rui, Yao, Chonghua, Kobayashi, Michihiro, Geng, Zhuangzhuang, Fahey, Aidan, Henley, Danielle, Liu, Stephen Z., Barajas, Sergio, Cai, Wenjie, Wolf, Eric R., Ramdas, Baskar, Cai, Zhigang, Gao, Hongyu, Luo, Na, Sun, Yang, Wong, Terrence N., Link, Daniel C., Liu, Yunlong, Boswell, H. Scott, Mayo, Lindsey D., Huang, Gang, Kapur, Reuben, Yoder, Mervin C., Broxmeyer, Hal E., Gao, Zhonghua, Liu, Yan

“…Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and is associated with increased risks of hematological malignancies. While TP53…”
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Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development by Nabinger, Sarah C., Chen, Sisi, Gao, Rui, Yao, Chonghua, Kobayashi, Michihiro, Vemula, Sasidhar, Fahey, Aidan C., Wang, Christine, Daniels, Cecil, Boswell, H. Scott, Sandusky, George E., Mayo, Lindsey D., Kapur, Reuben, Liu, Yan

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Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL by Mali, Raghuveer Singh, Ramdas, Baskar, Ma, Peilin, Shi, Jianjian, Munugalavadla, Veerendra, Sims, Emily, Wei, Lei, Vemula, Sasidhar, Nabinger, Sarah C., Goodwin, Charles B., Chan, Rebecca J., Traina, Fabiola, Visconte, Valeria, Tiu, Ramon V., Lewis, Timothy A., Stern, Andrew M., Wen, Qiang, Crispino, John D., Boswell, H. Scott, Kapur, Reuben

“…We show constitutive activation of Rho kinase (ROCK) in cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL, which is dependent on PI3K and Rho GTPase…”
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Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis by Chatterjee, Anindya, Ghosh, Joydeep, Ramdas, Baskar, Mali, Raghuveer Singh, Martin, Holly, Kobayashi, Michihiro, Vemula, Sasidhar, Canela, Victor H., Waskow, Emily R., Visconte, Valeria, Tiu, Ramon V., Smith, Catherine C., Shah, Neil, Bunting, Kevin D., Boswell, H. Scott, Liu, Yan, Chan, Rebecca J., Kapur, Reuben

“…Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms…”
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Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway by Chen, Sisi, Wang, Qiang, Yu, Hao, Capitano, Maegan L., Vemula, Sasidhar, Nabinger, Sarah C., Gao, Rui, Yao, Chonghua, Kobayashi, Michihiro, Geng, Zhuangzhuang, Fahey, Aidan, Henley, Danielle, Liu, Stephen Z., Barajas, Sergio, Cai, Wenjie, Wolf, Eric R., Ramdas, Baskar, Cai, Zhigang, Gao, Hongyu, Luo, Na, Sun, Yang, Wong, Terrence N., Link, Daniel C., Liu, Yunlong, Boswell, H. Scott, Mayo, Lindsey D., Huang, Gang, Kapur, Reuben, Yoder, Mervin C., Broxmeyer, Hal E., Gao, Zhonghua, Liu, Yan

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3 by Fukuda, Seiji, Singh, Pratibha, Moh, Akira, Abe, Mariko, Conway, Edward M., Boswell, H. Scott, Yamaguchi, Seiji, Fu, Xin-Yuan, Pelus, Louis M.

“…Internal tandem duplication mutations in the Flt3 tyrosine kinase gene (ITD-Flt3) and overexpression of Survivin are frequently found in patients with acute…”
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Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML by Sayar, Hamid, Liu, Yan, Gao, Rui, Zaid, Mohammad Abu, Cripe, Larry D, Weisenbach, Jill, Sargent, Katie J, Nassiri, Mehdi, Li, Lang, Konig, Heiko, Suvannasankha, Attaya, Pan, Feng, Shanmugam, Rajasubramaniam, Goswami, Chirayu, Kapur, Reuben, Xu, Mingjiang, Boswell, H Scott

“…Co-occurrence of and mutations provoke an animal model of AML by epigenetic repression of Wnt pathway antagonists, including and by hyperexpression of encoding…”
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Novel Combination Treatments Targeting Chronic Myeloid Leukemia Stem Cells by Al Baghdadi, Tareq, Abonour, Rafat, Boswell, H. Scott

“…Abstract Chronic myeloid leukemia (CML) is currently considered incurable in most patients. Stem cell transplantation, an accepted curative option for which…”
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Antimyeloma Effects of a Sesquiterpene Lactone Parthenolide by SUVANNASANKHA, Attaya, CREAN, Colin D, SHANMUGAM, Rajasubramaniam, FARAG, Sherif S, ABONOUR, Rafat, BOSWELL, H. Scott, NAKSHATRI, Harikrishna

“…Purpose: Nuclear factor-κB (NF-κB), activated in multiple myeloma (MM) cells by microenvironmental cues, confers resistance to apoptosis. The sesquiterpene…”
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Notch-Dependent Repression of miR-155 in the Bone Marrow Niche Regulates Hematopoiesis in an NF-κB-Dependent Manner by Wang, Lin, Zhang, Huajia, Rodriguez, Sonia, Cao, Liyun, Parish, Jonathan, Mumaw, Christen, Zollman, Amy, Kamoka, Malgorzata M., Mu, Jian, Chen, Danny Z., Srour, Edward F., Chitteti, Brahmananda R., HogenEsch, Harm, Tu, Xiaolin, Bellido, Teresita M., Boswell, H. Scott, Manshouri, Taghi, Verstovsek, Srdan, Yoder, Mervin C., Kapur, Reuben, Cardoso, Angelo A., Carlesso, Nadia

“…The microRNA miR-155 has been implicated in regulating inflammatory responses and tumorigenesis, but its precise role in linking inflammation and cancer has…”
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Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation by CRIPE, L. D, GELFANOV, V. M, MERCOLA, D, BURGESS, G. S, BOSWELL, H. Scott, SMITH, E. A, SPIGEL, D. R, PHILLIPS, C. A, GABIG, T. G, JUNG, S-H, FYFFE, J, HARTMAN, A. D, KNEEBONE, P

“…A relationship was proved between constitutive activity of leukemic cell c-jun-N-terminal kinase (JNK) and treatment failure in AML. Specifically, early…”
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Pharmacological inhibition of Carbonic Anhydrase IX and XII to enhance targeting of acute myeloid leukaemia cells under hypoxic conditions by Chen, Fangli, Licarete, Emilia, Wu, Xue, Petrusca, Daniela, Maguire, Callista, Jacobsen, Max, Colter, Austyn, Sandusky, George E., Czader, Magdalena, Capitano, Maegan L., Ropa, James P., Boswell, H. Scott, Carta, Fabrizio, Supuran, Claudiu T., Parkin, Brian, Fishel, Melissa L., Konig, Heiko

“…Acute myeloid leukaemia (AML) is an aggressive form of blood cancer that carries a dismal prognosis. Several studies suggest that the poor outcome is due to a…”
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PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371 by Chen, Hongxia, Bai, Yunpeng, Kobayashi, Michihiro, Xiao, Shiyu, Cai, Wenjie, Barajas, Sergio, Chen, Sisi, Miao, Jinmin, Meke, Frederick Nguele, Vemula, Sasidhar, Ropa, James P., Croop, James M., Boswell, H. Scott, Wan, Jun, Jia, Yuzhi, Liu, Huiping, Li, Loretta S., Altman, Jessica K., Eklund, Elizabeth A., Ji, Peng, Tong, Wei, Band, Hamid, Huang, Danny T., Platanias, Leonidas C., Zhang, Zhong-Yin, Liu, Yan

“…•Genetic and pharmacological inhibition of PRL2 significantly reduce FLT3-ITD-driven leukemia burden and extend leukemic mice survival.•PRL2 dephosphorylates…”
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Classic and targeted anti‐leukaemic agents interfere with the cholesterol biogenesis metagene in acute myeloid leukaemia: Therapeutic implications by Chen, Fangli, Wu, Xue, Niculite, Cristina, Gilca, Marilena, Petrusca, Daniela, Rogozea, Adriana, Rice, Susan, Guo, Bin, Griffin, Shawn, Calin, George A., Boswell, H. Scott, Konig, Heiko

“…Despite significant advances in deciphering the molecular landscape of acute myeloid leukaemia (AML), therapeutic outcomes of this haematological malignancy…”
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Combination of sorafenib, vorinostat and bortezomib for the treatment of poor-risk AML: report of two consecutive clinical trials by Sayar, Hamid, Cripe, Larry D., Saliba, Antoine N., Abu Zaid, Mohammad, Konig, Heiko, Boswell, H. Scott

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PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation by Chen, Hongxia, Bai, Yunpeng, Kobayashi, Michihiro, Xiao, Shiyu, Barajas, Sergio, Cai, Wenjie, Chen, Sisi, Miao, Jinmin, Nguele Meke, Frederick, Yao, Chonghua, Yang, Yuxia, Strube, Katherine, Satchivi, Odelia, Sun, Jianmin, Rönnstrand, Lars, Croop, James M, Boswell, H Scott, Jia, Yuzhi, Liu, Huiping, Li, Loretta S, Altman, Jessica K, Eklund, Elizabeth A, Sukhanova, Madina, Ji, Peng, Tong, Wei, Band, Hamid, Huang, Danny T, Platanias, Leonidas C, Zhang, Zhong-Yin, Liu, Yan

“…Receptor tyrosine kinase KIT is frequently activated in acute myeloid leukemia (AML). While high PRL2 (PTP4A2) expression is correlated with activation of…”
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Death-associated Protein Kinase-1 Expression and Autophagy in Chronic Lymphocytic Leukemia Are Dependent on Activating Transcription Factor-6 and CCAAT/Enhancer-binding Protein-β by Gade, Padmaja, Kimball, Amy S, DiNardo, Angela C, Gangwal, Priyamvada, Ross, Douglas D, Boswell, H Scott, Keay, Susan K, Kalvakolanu, Dhananjaya V

“…Expression of DAPK1, a critical regulator of autophagy and apoptosis, is lost in a wide variety of tumors, although the mechanisms are unclear. A transcription…”
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A Noncanonical Flt3ITD/NF-κB Signaling Pathway Represses DAPK1 in Acute Myeloid Leukemia by SHANMUGAM, Rajasubramaniam, GADE, Padmaja, SARGENT, Katie J, CRIPE, Larry D, KALVAKOLANU, Dhananjaya V, BOSWELL, H. Scott, WILSON-WEEKES, Annique, SAYAR, Hamid, SUVANNASANKHA, Attaya, GOSWAMI, Chirayu, LANG LI, GUPTA, Sushil, CARDOSO, Angelo A, BAGHDADI, Tareq Al

“…Death-associated protein kinase 1 (DAPK1), a tumor suppressor, is a rate-limiting effector in an endoplasmic reticulum (ER) stress-dependent apoptotic pathway…”
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Paclitaxel sensitivity of breast cancer cells with constitutively active NF-κB is enhanced by IκBα super-repressor and parthenolide by Patel, Nikhil M, Nozaki, Shinichi, Shortle, Nicholas H, Bhat-Nakshatri, Poornima, Newton, Thomas R, Rice, Susan, Gelfanov, Vasily, Boswell, Scott H, Goulet, Robert J, Sledge, George W, Nakshatri, Harikrishna

“…The transcription factor nuclear factor-κB (NF-κB) regulates genes important for tumor invasion, metastasis and chemoresistance. Normally, NF-κB remains…”
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Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation by Hartman, Amy D., Wilson-Weekes, Annique, Suvannasankha, Attaya, Burgess, Gem S., Phillips, Carissa A., Hincher, Katie J., Cripe, Larry D., Boswell, H. Scott

“…c-jun N-terminal kinase (JNK) has been implicated in proliferation and survival downstream from the tyrosine kinase oncogene, p210 BCR-ABL, in chronic myeloid…”
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