Search Results - "Boswell, George A."

An Unusual Trifluoromethyl Elimination Reaction from the 4,4-Bis(trifluoromethyl)-5-hydroxyimidazoline Ring System by Li, Hui-Yin, DeLucca, Indawati, Drummond, Spencer, Boswell, George A

“…A facile detrifluoromethylation was observed when 4,4-bis(trifluoromethyl)-5-hydroxyimidazoline 5 was treated with a variety of bases to afford the…”
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Steroidal nitrone inhibitors of 5α-reductase by Robinson, Andrea J, DeLucca, Indawati, Drummond, Spencer, Boswell, George A

“…This paper describes the rational design and synthesis of novel inhibitors of human steroid 5α-reductase. Steroidal nitrones were synthesised via an eight-step…”
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Reaction of nitrosyl fluoride and selected steroid enes. New synthesis of .DELTA.5-4-keto steroids by Boswell, George A

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N-Nitroaziridines: synthesis, thermal stability, and solvolytic reactivity by Haire, Michael J, Boswell, George A

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Novel 4,4-bis(trifluoromethyl) imidazolines as stereospecific and orally active acyl coa: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents by Boswell, George A, Li, Hui-Yin, Delucca, Indawati, Billheimer, Jeffrey T., Drummond, Spencer, Gillies, Peter J., Robinson, Candy

“…A new class of very potent, systemically-active ACAT inhibitors based on a 4,4-bis(trifluoromethyl)imidazoline ring has been discovered. Compound 6 and its…”
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THE CHARACTERIZATION OF POTENT NOVEL WARFARIN ANALOGS by Kerr, Janet S, Li, Hui-Yin, Wexler, Roseanne S, Robinson, Andrea J, Robinson, Candy S, Boswell, George A, Krauthauser, Candice, Harlow, Patricia P

“…Racemic sodium warfarin, Coumadin,® is widely used in the prevention of thromboembolic disease. The present study was undertaken to characterize three novel…”
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Base Catalyzed Autoxidation of Cyclic 1,4-Diketones to Enediones by DAUBEN, WILLIAM G, BOSWELL, GEORGE A, TEMPLETON, WILLIAM

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Synthesis of 5α,6,6-Trifluoro-3-keto and 6,6-Difluoro-Δ4-3-keto Steroids by Boswell, George A

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Persistent cardioprotection by azapropazone in a canine model of coronary artery thrombosis and thrombolysis by Knabb, R M, Rasbach, D E, Leamy, A W, Fernando, D P, Mackin, W M, Boswell, G A, Timmermans, P B, Thoolen, M J

“…Activated neutrophils and possibly xanthine oxidase-derived free radicals are believed to be mediators of ischemia and reperfusion-induced myocardial damage…”
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Singlet oxygen oxidation of pyrroles: Synthesis and chemical transformations of novel 4,4-bis(trifluoromethyl)imidazoline analogs by Li, Hui-Yin, Drummond, Spencer, DeLucca, Indawati, Boswell, George A.

“…Singlet oxygen or mCPBA oxidation of pyrrole 5b afforded a new series of 4,4-bis(trifluoromethyl)imidazolines with a para-substituted phenacyl side chain which…”
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Synthesis of A-Norcholesterol by Dauben, William G, Boswell, George A

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The Preparation of 8α-B-Norsteroid Derivatives by Dauben, William G, Boswell, George A, Templeton, William, McFarland, James W

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Synthesis of Δ3(5)-A-Norcholestene-2-one1 by Dauben, William G, Boswell, George A, Templeton, William H

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The Biosynthesis of Ergosterol: Its Relationship to the Squalene Hypothesis1,2 by Dauben, William G, Hutton, Thomas W, Boswell, George A

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THE BIOSYNTHETIC PRECURSOR OF THE EXTRA CARBON ATOM IN THE SIDE-CHAIN OF STEROIDS1 by Dauben, William G, Fonken, Gerhard J, Boswell, George A

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The Configuration of B-Norsteroid Derivatives by Dauben, William G, Boswell, George A, Templeton, William, McFarland, James W, Berezin, Gilbert H

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Synthesis of 6,6-difluoronorethindrone by Boswell, George A, Johnson, Alexander Lawrence, McDevitt, Joseph P

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THE CONFIGURATION OF B-NORSTEROID DERIVATIVES by Dauben, William G, Boswell, George A, Berezin, Gilbert H

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A facile synthesis of fluorinated 4-hydroxycoumarins by Li, Hui-Yin, Boswell, George A.

“…Fluorinated 4-hydroxycoumarins were prepared from readily available fluorinated phenols via a AlCl 3 catalyzed Friedel-Crafts ring closure and followed by…”
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Asymmetric synthesis and absolute stereochemistry of 4,4-bis-(trifluoromethyl)imidazoline based ACAT inhibitors by Li, Hui-Yin, DeLucca, Indawati, Drummond, Spencer, Boswell, George A.

“…An asymmetric synthesis of 1, a potent orally active ACAT inhibitor, is reported. The absolute configuration of 1 has been determined by exciton CD spectra and…”
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