Search Results - "Boswell, C"

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies by Bien-Ly, Nga, Boswell, C. Andrew, Jeet, Surinder, Beach, Thomas G., Hoyte, Kwame, Luk, Wilman, Shihadeh, Vera, Ulufatu, Sheila, Foreman, Oded, Lu, Yanmei, DeVoss, Jason, van der Brug, Marcel, Watts, Ryan J.

“…The blood-brain barrier (BBB) limits brain uptake of therapeutic antibodies. It is believed that the BBB is disrupted in Alzheimer’s disease (AD), potentially…”
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Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature by Grimes, D. T., Boswell, C. W., Morante, N. F. C., Henkelman, R. M., Burdine, R. D., Ciruna, B.

“…Idiopathic scoliosis (IS) affects 3% of children worldwide, yet the mechanisms underlying this spinal deformity remain unknown. Here we show that ptk7 mutant…”
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Relative Target Affinities of T-Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model by Mandikian, Danielle, Takahashi, Nene, Lo, Amy A, Li, Ji, Eastham-Anderson, Jeffrey, Slaga, Dionysos, Ho, Jason, Hristopoulos, Maria, Clark, Robyn, Totpal, Klara, Lin, Kedan, Joseph, Sean B, Dennis, Mark S, Prabhu, Saileta, Junttila, Teemu T, Boswell, C Andrew

“…Anti-HER2/CD3, a T-cell-dependent bispecific antibody (TDB) construct, induces T-cell-mediated cell death in cancer cells expressing HER2 by cross-linking…”
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Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants by Bien-Ly, Nga, Yu, Y Joy, Bumbaca, Daniela, Elstrott, Justin, Boswell, C Andrew, Zhang, Yin, Luk, Wilman, Lu, Yanmei, Dennis, Mark S, Weimer, Robby M, Chung, Inhee, Watts, Ryan J

“…Antibodies to transferrin receptor (TfR) have potential use for therapeutic entry into the brain. We have shown that bispecific antibodies against TfR and…”
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Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics by Boswell, C. Andrew, Tesar, Devin B., Mukhyala, Kiran, Theil, Frank-Peter, Fielder, Paul J., Khawli, Leslie A.

“…Antibody pharmacokinetics and pharmacodynamics are often governed by biological processes such as binding to antigens and other cognate receptors. Emphasis…”
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Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor by Deng, Rong, Bumbaca, Daniela, Pastuskovas, Cinthia V, Boswell, C Andrew, West, David, Cowan, Kyra J, Chiu, Henry, McBride, Jacqueline, Johnson, Clarissa, Xin, Yan, Koeppen, Hartmut, Leabman, Maya, Iyer, Suhasini

“…MPDL3280A is a human monoclonal antibody that targets programmed cell death-1 ligand 1 (PD-L1), and exerts anti-tumor activity mainly by blocking PD-L1…”
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Development of radioimmunotherapeutic and diagnostic antibodies: an inside-out view by Boswell, C. Andrew, Brechbiel, Martin W

“…Abstract Only a handful of radiolabeled antibodies (Abs) have gained US Food and Drug Administration (FDA) approval for use in clinical oncology, including…”
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Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer by Lo, Amy A, Johnston, Jennifer, Li, Ji, Mandikian, Danielle, Hristopoulos, Maria, Clark, Robyn, Nickles, Dorothee, Liang, Wei-Ching, Hötzel, Kathy, Dunlap, Debra, Pham, Thinh, Cai, Hao, Ovacik, Meric, Bravo-Perez, Daniel, Mai, Elaine, Slaga, Dionysos, Ellerman, Diego, Ziai, James, Totpal, Klara, Lee, Genee, Boswell, C Andrew, Payandeh, Jian, Wu, Yan, Junttila, Teemu T

“…Ovarian cancer is a diverse class of tumors with very few effective treatment options and suboptimal response rates in early clinical studies using…”
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Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics by Bumbaca, Daniela, Boswell, C. Andrew, Fielder, Paul J., Khawli, Leslie A.

“…Monoclonal antibodies are increasingly being developed to treat multiple disease areas, including those related to oncology, immunology, neurology, and…”
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Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats by Boswell, C. Andrew, Mundo, Eduardo E, Zhang, Crystal, Bumbaca, Daniela, Valle, Nicole R, Kozak, Katherine R, Fourie, Aimee, Chuh, Josefa, Koppada, Neelima, Saad, Ola, Gill, Herman, Shen, Ben-Quan, Rubinfeld, Bonnee, Tibbitts, Jay, Kaur, Surinder, Theil, Frank-Peter, Fielder, Paul J, Khawli, Leslie A, Lin, Kedan

“…Antibody–drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of…”
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Assessment of university policies for service animals and emotional support animals by Lanning, Beth A., Patterson, M. S., Henry, S., Graves-Boswell, C. T., Summerall, B., Millan, C.

“…Assess administrative responsibilities and experiential effects of emotional support animal (ESA) and service animal (SA) policies on college campuses…”
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Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies by Rafidi, Hanine, Rajan, Sharmila, Urban, Konnie, Shatz-Binder, Whitney, Hui, Keliana, Ferl, Gregory Z., Kamath, Amrita V., Boswell, C. Andrew

“…Advances in antibody engineering have enabled the construction of novel molecular formats in diverse shapes and sizes, providing new opportunities for biologic…”
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On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy by Adhikari, Pragya, Li, Guangmin, Go, MaryAnn, Mandikian, Danielle, Rafidi, Hanine, Ng, Carl, Anifa, Sagana, Johnson, Kevin, Bao, Linda, Hernandez Barry, Hilda, Rowntree, Rebecca, Agard, Nicholas, Wu, Cong, Chou, Kang-Jye, Zhang, Donglu, Kozak, Katherine R., Pillow, Thomas H., Lewis, Gail D., Yu, Shang-Fan, Boswell, C. Andrew, Sadowsky, Jack D.

“…Antibody-drug conjugates (ADCs) for the treatment of cancer aim to achieve selective delivery of a cytotoxic payload to tumor cells while sparing normal…”
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Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge by Li, Bing, Tesar, Devin, Boswell, C Andrew, Cahaya, Hendry S, Wong, Anne, Zhang, Jianhuan, Meng, Y Gloria, Eigenbrot, Charles, Pantua, Homer, Diao, Jinyu, Kapadia, Sharookh B, Deng, Rong, Kelley, Robert F

“…Pharmacokinetic (PK) testing of a humanized (κI, VH3 framework) and affinity matured anti-hepatitis C virus E2-glycoprotein (HCV-E2) antibody (hu5B3.κ1VH3.v3)…”
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Increased diaphragm motor unit discharge frequencies during quiet breathing in people with chronic tetraplegia by Nguyen, D. A. T., Lewis, R. H. C., Boswell‐Ruys, C. L., Hudson, A. L., Gandevia, S. C., Butler, Jane E.

“…Key points Respiratory muscle strength is compromised in people with tetraplegia, which may be compensated for by an increase in neural drive to the diaphragm…”
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Hyaluronic Acid–Antibody Fragment Bioconjugates for Extended Ocular Pharmacokinetics by Famili, Amin, Crowell, Susan R, Loyet, Kelly M, Mandikian, Danielle, Boswell, C. Andrew, Cain, David, Chan, Joyce, Comps-Agrar, Laetitia, Kamath, Amrita, Rajagopal, Karthikan

“…Treatment of ocular diseases associated with neovascularization currently requires frequent intravitreal injections of antivascular endothelial growth factor…”
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Comparative in Vivo Stability of Copper-64-Labeled Cross-Bridged and Conventional Tetraazamacrocyclic Complexes by Boswell, C. Andrew, Sun, Xiankai, Niu, Weijun, Weisman, Gary R, Wong, Edward H, Rheingold, Arnold L, Anderson, Carolyn J

“…The increased use of copper radioisotopes in radiopharmaceutical applications has created a need for bifunctional chelators (BFCs) that form stable radiocopper…”
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Imaging Reveals Importance of Shape and Flexibility for Glomerular Filtration of Biologics by Rafidi, Hanine, Estevez, Alberto, Ferl, Gregory Z, Mandikian, Danielle, Stainton, Shannon, Sermeño, Lauren, Williams, Simon P, Kamath, Amrita V, Koerber, James T, Boswell, C Andrew

“…Advances in antibody engineering have enabled the construction of novel molecular formats in diverse shapes and sizes, providing new opportunities for cancer…”
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Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis by Van Gennip, J L M, Boswell, C W, Ciruna, B

“…The etiopathogenesis of idiopathic scoliosis (IS), a highly prevalent spinal deformity that occurs in the absence of obvious congenital or physiological…”
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Production, characterization, and in vivo half-life extension of polymeric IgA molecules in mice by Lombana, T Noelle, Rajan, Sharmila, Zorn, Julie A, Mandikian, Danielle, Chen, Eugene C, Estevez, Alberto, Yip, Victor, Bravo, Daniel D, Phung, Wilson, Farahi, Farzam, Viajar, Sharon, Lee, Sophia, Gill, Avinash, Sandoval, Wendy, Wang, Jianyong, Ciferri, Claudio, Boswell, C Andrew, Matsumoto, Marissa L, Spiess, Christoph

“…IgA antibodies have broad potential as a novel therapeutic platform based on their superior receptor-mediated cytotoxic activity, potent neutralization of…”
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