Search Results - "Bostwick, J Robert"

Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations by Mutyam, Venkateshwar, Du, Ming, Xue, Xiaojiao, Keeling, Kim M, White, E Lucile, Bostwick, J Robert, Rasmussen, Lynn, Liu, Bo, Mazur, Marina, Hong, Jeong S, Falk Libby, Emily, Liang, Feng, Shang, Haibo, Mense, Martin, Suto, Mark J, Bedwell, David M, Rowe, Steven M

“…Premature termination codons (PTCs) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF). Several agents are known…”
Get full text

Targeting EMT using low-dose Teniposide by downregulating ZEB2-driven activation of RNA polymerase I in breast cancer by Metge, Brandon J., Alsheikh, Heba Allah M., Kammerud, Sarah C., Chen, Dongquan, Das, Devika, Nebane, N. Miranda, Bostwick, J. Robert, Shevde, Lalita A., Samant, Rajeev S.

“…Metastatic dissemination from the primary tumor is a complex process that requires crosstalk between tumor cells and the surrounding milieu and involves the…”
Get full text

Discovery of a novel inhibitor of kinesin-like protein KIFC1 by Zhang, Wei, Zhai, Ling, Wang, Yimin, Boohaker, Rebecca J, Lu, Wenyan, Gupta, Vandana V, Padmalayam, Indira, Bostwick, Robert J, White, E Lucile, Ross, Larry J, Maddry, Joseph, Ananthan, Subramaniam, Augelli-Szafran, Corinne E, Suto, Mark J, Xu, Bo, Li, Rongbao, Li, Yonghe

“…Historically, drugs used in the treatment of cancers also tend to cause damage to healthy cells while affecting cancer cells. Therefore, the identification of…”
Get more information

A high-throughput response to the SARS-CoV-2 pandemic by Rasmussen, Lynn, Sanders, Shalisa, Sosa, Melinda, McKellip, Sara, Nebane, N. Miranda, Martinez-Gzegozewska, Yohanka, Reece, Andrew, Ruiz, Pedro, Manuvakhova, Anna, Zhai, Ling, Warren, Brooke, Curry, Aliyah, Zeng, Qinghua, Bostwick, J. Robert, Vinson, Paige N.

“…Four years after the beginning of the COVID-19 pandemic, it is important to reflect on the events that have occurred during that time and the knowledge that…”
Get full text

Accelerating Drug Development: Antiviral Therapies for Emerging Viruses as a Model by Everts, Maaike, Cihlar, Tomas, Bostwick, J. Robert, Whitley, Richard J

“…Drug discovery and development is a lengthy and expensive process. Although no one, simple, single solution can significantly accelerate this process, steps…”
Get full text

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion by Sharma, Jyoti, Du, Ming, Wong, Eric, Mutyam, Venkateshwar, Li, Yao, Chen, Jianguo, Wangen, Jamie, Thrasher, Kari, Fu, Lianwu, Peng, Ning, Tang, Liping, Liu, Kaimao, Mathew, Bini, Bostwick, Robert J., Augelli-Szafran, Corinne E., Bihler, Hermann, Liang, Feng, Mahiou, Jerome, Saltz, Josef, Rab, Andras, Hong, Jeong, Sorscher, Eric J., Mendenhall, Eric M., Coppola, Candice J., Keeling, Kim M., Green, Rachel, Mense, Martin, Suto, Mark J., Rowe, Steven M., Bedwell, David M.

“…Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also…”
Get full text

Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2 by Liu, Jay J, Payza, Kemal, Huang, Jian, Liu, Ruifeng, Chen, Tongming, Coupal, Martin, Laird, Jennifer M A, Cao, Chang-Qing, Butterworth, Joanne, Lapointe, Stéphanie, Bayrakdarian, Malken, Trivedi, Shephali, Bostwick, J Robert

“…Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy…”
Get more information

Development of small-molecule Tau-SH3 interaction inhibitors that prevent amyloid-β toxicity and network hyperexcitability by Roth, Jonathan R., Rush, Travis, Thompson, Samantha J., Aldaher, Adam R., Dunn, Trae B., Mesina, Jacob S., Cochran, J. Nicholas, Boyle, Nicholas R., Dean, Hunter B., Yang, Zhengrong, Pathak, Vibha, Ruiz, Pedro, Wu, Mousheng, Day, Jeremy J., Bostwick, J. Robert, Suto, Mark J., Augelli-Szafran, Corinne E., Roberson, Erik D.

“…Alzheimer's disease (AD) is the leading cause of dementia and lacks highly effective treatments. Tau-based therapies hold promise. Tau reduction prevents…”
Get full text

Identification of Quinolinones as Antivirals against Venezuelan Equine Encephalitis Virus by Haese, Nicole N, May, Nicholas A, Taft-Benz, Sharon, Moukha-Chafiq, Omar, Madadi, Nikhil, Zhang, Sixue, Karyakarte, Shuklendu D, Rodzinak, Kevin J, Nguyen, Theresa H, Denton, Michael, Streblow, Aaron D, Towers, Nichole A, Rasmussen, Lynn, Bostwick, Robert J, Maddry, Joseph A, Ananthan, Subramaniam, Augelli-Szafran, Corinne E, Suto, Mark J, Sanders, Wes, Moorman, Nathaniel, DeFilippis, Victor, Heise, Mark T, Pathak, Ashish K, Streblow, Daniel N, Morrison, Thomas E

“…Venezuelan equine encephalitis virus (VEEV) is a reemerging alphavirus that can cause encephalitis resulting in severe human morbidity and mortality. Using a…”
Get full text

Design, Synthesis, and Structure–Activity Relationship Studies of a Series of [4-(4-Carboxamidobutyl)]-1-arylpiperazines: Insights into Structural Features Contributing to Dopamine D3 versus D2 Receptor Subtype Selectivity by Ananthan, Subramaniam, Saini, Surendra K, Zhou, Guangyan, Hobrath, Judith V, Padmalayam, Indira, Zhai, Ling, Bostwick, J. Robert, Antonio, Tamara, Reith, Maarten E. A, McDowell, Shea, Cho, Eunie, McAleer, Leah, Taylor, Michelle, Luedtke, Robert R

“…Antagonist and partial agonist modulators of the dopamine D3 receptor (D3R) have emerged as promising therapeutics for the treatment of substance abuse and…”
Get full text

Triamterene normalizes glycosaminoglycan accumulation in an IDUA-W402X mouse model of MPS I (Hurler syndrome) via nonsense suppression by Bedwell, David, Siddiqui, Amna, Dundar, Halil, Echols, Josh, Du, Ming, Rasmussen, Lynn, Robert Bostwick, J., Suto, Mark, Keeling, Kim

Get full text

Development of small‐molecule tau‐SH3 interaction inhibitors that prevent amyloid‐β toxicity by Roth, Jonathan R, Rush, Travis, Pugh, Derian A, Dean, Hunter B, Cochran, J. Nicholas, Thompson, Samantha J, Aldaher, Adam R, Mesina, Jacob S, Ruiz, Pedro, Pathak, Vibha, Wu, Mousheng, Bostwick, J Robert, Suto, Mark J, Augelli‐Szafran, Corinne E, Roberson, Erik D.

“…Background Alzheimer’s disease (AD) is the leading cause of dementia and lacks disease‐modifying treatments. Tau‐based therapies are attractive and Tau…”
Get full text

Abstract 1746: Discovery and evaluation of a small molecule KIFC1 inhibitor for breast cancer treatment by Zhang, Wei, Zhai, Ling, Lu, Wenyan, Wang, Yimin, Gupta, Vandana V., Padmalayam, Indira, Bostwick, Robert J., White, Lucile, Larry, Ross, Maddry, Joseph, Ananthan, Sam, Suto, Mark, Xu, Bo, Li, Rongbao, Li, Yonghe

“…Abstract Historically, drugs used in the treatment of certain cancers may cause damage to healthy cells while affecting cancer cells. Therefore, finding…”
Get full text

Phosphoethanolamine enhances high-affinity choline uptake and acetylcholine synthesis in dissociated cell cultures of the rat septal nucleus by Bostwick, J R, Abbe, R, Appel, S H

“…Dissociated rat septal nucleus cells cultured in defined medium exhibited twofold increases in the maximal rates of sodium-dependent, high-affinity choline…”
Get more information

Amino alcohol modulation of hippocampal acetylcholine release by Bostwick, J R, Abbe, R, Sun, J, Appel, S H

“…The synthesis and release of 3H-acetylcholine was measured in hippocampal slices of adult rat brain following acute in vitro exposure to ethanolamine. Evoked…”
Get more information

Functional coupling of the Galpha(olf) variant XLGalpha(olf) with the human adenosine A2A receptor by Ravyn, Vipa, Bostwick, J Robert

“…A recently identified novel Galphaolf variant, XLGalphaolf, is shown to functionally couple to the human adenosine A2A receptor (A2AR). In Sf9 cells expressing…”
Get full text

Functional Coupling of the G αolf Variant XLG αolf with the Human Adenosine A 2A Receptor by RAVYN, VIPA, BOSTWICK, J. ROBERT

Get full text

Functional Coupling of the Gαolf Variant XLGαolf with the Human Adenosine A2A Receptor by RAVYN, VIPA, BOSTWICK, J. ROBERT

“…A recently identified novel Gαolf variant, XLGαolf, is shown to functionally couple to the human adenosine A2A receptor (A2AR). In Sf9 cells expressing A2AR,…”
Get full text

A tyrosine hydroxylase assay in microwells using coupled nonenzymatic decarboxylation of dopa by Bostwick, J R, Le, W D

“…A radiometric assay for tyrosine hydroxylase employing a coupled nonenzymatic decarboxylation of L-[14C]Dopa formed from L-[14C]tyrosine has been adapted for…”
Get more information

Modulation of acetylcholine release in rat hippocampus by amino alcohols and Bay K 8644 by Bostwick, J R, Abbe, R, Appel, S H

“…The amino alcohols ethanolamine, R-alaninol and R-prolinol were shown to enhance high potassium evoked release of [3H]acetylcholine from hippocampal slices by…”
Get more information