Search Results - "Bossenmeyer‐Pourié, Carine"

N‐homocysteinylation of tau and MAP1 is increased in autopsy specimens of Alzheimer's disease and vascular dementia by Bossenmeyer‐Pourié, Carine, Smith, A David, Lehmann, Sylvain, Deramecourt, Vincent, Sablonnière, Bernard, Camadro, Jean‐Michel, Pourié, Grégory, Kerek, Racha, Helle, Deborah, Umoret, Remy, Guéant‐Rodriguez, Rosa‐Maria, Rigau, Valérie, Gabelle, Audrey, Sequeira, Jeffrey M, Quadros, Edward V, Daval, Jean‐Luc, Guéant, Jean‐Louis

“…The pathomechanisms that associate a deficit in folate and/or vitamin B12 and the subsequent hyperhomocysteinemia with pathological brain ageing are unclear…”
Get full text

The Fate of Transplanted Olfactory Progenitors Is Conditioned by the Cell Phenotypes of the Receiver Brain Tissue in Cocultures by Pourié, Grégory, Akchiche, Nassila, Millot, Jean-Louis, Guéant, Jean-Louis, Daval, Jean-Luc, Bossenmeyer-Pourié, Carine

“…Among the numerous candidates for cell therapy of the central nervous system (CNS), olfactory progenitors (OPs) represent an interesting alternative because…”
Get full text

Homocysteinylation of neuronal proteins contributes to folate deficiency‐associated alterations of differentiation, vesicular transport, and plasticity in hippocampal neuronal cells by Akchiche, Nassila, Bossenmeyer‐Pourié, Carine, Kerek, Racha, Martin, Nicolas, Pourié, Grégory, Koziel, Violette, Helle, Déborah, Alberto, Jean‐Marc, Ortiou, Sandrine, Camadro, Jean‐Michel, Léger, Thibaut, Guéant, Jean‐Louis, Daval, Jean‐Luc

“…Despite the key role in neuronal development of a deficit in the methyl donor folate, little is known on the underlying mechanisms. We therefore studied the…”
Get full text

Folate and Cobalamin Deficiencies during Pregnancy Disrupt the Glucocorticoid Response in Hypothalamus through N -Homocysteinilation of the Glucocorticoid Receptor by Michel, Arnaud, Kokten, Tunay, Saber-Cherif, Lynda, Umoret, Rémy, Alberto, Jean-Marc, Helle, Déborah, Julien, Amélia, Daval, Jean-Luc, Guéant, Jean-Louis, Bossenmeyer-Pourié, Carine, Pourié, Grégory

“…Vitamin B9 (folate)/B12 (cobalamin) deficiency is known to induce brain structural and/or functional retardations. In many countries, folate supplementation,…”
Get full text

Developmental Impairments in a Rat Model of Methyl Donor Deficiency: Effects of a Late Maternal Supplementation with Folic Acid by Geoffroy, Andréa, Saber-Cherif, Lynda, Pourié, Grégory, Helle, Déborah, Umoret, Rémy, Guéant, Jean-Louis, Bossenmeyer-Pourié, Carine, Daval, Jean-Luc

“…Vitamins B9 (folate) and B12 act as methyl donors in the one-carbon metabolism which influences epigenetic mechanisms. We previously showed that an embryofetal…”
Get full text

The Stimulation of Neurogenesis Improves the Cognitive Status of Aging Rats Subjected to Gestational and Perinatal Deficiency of B9-12 Vitamins by Pourié, Grégory, Martin, Nicolas, Daval, Jean-Luc, Alberto, Jean-Marc, Umoret, Rémy, Guéant, Jean-Louis, Bossenmeyer-Pourié, Carine

“…A deficiency in B-vitamins is known to lead to persistent developmental defects in various organs during early life. The nervous system is particularly…”
Get full text

Mouse bone marrow contains large numbers of functionally competent neutrophils by Boxio, Rachel, Bossenmeyer‐Pourié, Carine, Steinckwich, Natacha, Dournon, Christian, Nüße, Oliver

“…The mouse has become an important model for immunological studies including innate immunity. Creating transgenic mice offers unique possibilities to study…”
Get full text

Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus by Saber Cherif, Lynda, Pourié, Grégory, Geoffroy, Andréa, Julien, Amélia, Helle, Déborah, Robert, Aurélie, Umoret, Rémy, Guéant, Jean-Louis, Bossenmeyer-Pourié, Carine, Daval, Jean-Luc

“…The micronutrients vitamins B9 and B12 act as methyl donors in the one-carbon metabolism involved in transmethylation reactions which critically influence…”
Get full text

Cognitive Impairment Is Associated with AMPAR Glutamatergic Dysfunction in a Mouse Model of Neuronal Methionine Synthase Deficiency by Hassan, Ziad, Coelho, David, Bossenmeyer-Pourié, Carine, Matmat, Karim, Arnold, Carole, Savladori, Aurélie, Alberto, Jean-Marc, Umoret, Rémy, Guéant, Jean-Louis, Pourié, Grégory

“…Impairment of one-carbon metabolism during pregnancy, either due to nutritional deficiencies in B9 or B12 vitamins or caused by specific genetic defects, is…”
Get full text

Early methyl donor deficiency produces severe gastritis in mothers and offspring through N‐homocysteinylation of cytoskeleton proteins, cellular stress, and inflammation by Bossenmeyer‐Pourié, Carine, Pourié, Grégory, Koziel, Violette, Helle, Deborah, Jeannesson, Elise, Guéant, Jean‐Louis, Beck, Bernard

“…We examined the gastric mucosa structure and inflammatory status in control well‐nourished Wistar dams and in Wistar dams deprived of choline, folate, and…”
Get full text

Gestational Vitamin B Deficiency Leads to Homocysteine-Associated Brain Apoptosis and Alters Neurobehavioral Development in Rats by Blaise, Sébastien A, Nédélec, Emmanuelle, Schroeder, Henri, Alberto, Jean-Marc, Bossenmeyer-Pourié, Carine, Guéant, Jean-Louis, Daval, Jean-Luc

“…Hyperhomocysteinemia has been identified as a risk factor for neurological disorders. To study the influence of early deficiency in nutritional determinants of…”
Get full text

Non-injurious neonatal hypoxia confers resistance to brain senescence in aged male rats by Martin, Nicolas, Bossenmeyer-Pourié, Carine, Koziel, Violette, Jazi, Rozat, Audonnet, Sandra, Vert, Paul, Guéant, Jean-Louis, Daval, Jean-Luc, Pourié, Grégory

“…Whereas brief acute or intermittent episodes of hypoxia have been shown to exert a protective role in the central nervous system and to stimulate neurogenesis,…”
Get full text

The Trefoil Factor 1 Participates in Gastrointestinal Cell Differentiation by Delaying G1-S Phase Transition and Reducing Apoptosis by Bossenmeyer-Pourié, Carine, Kannan, Rama, Ribieras, Stéphane, Wendling, Corinne, Stoll, Isabelle, Thim, Lars, Tomasetto, Catherine, Rio, Marie-Christine

“…Trefoil factor (TFF)1 is synthesized and secreted by the normal stomach mucosa and by the gastrointestinal cells of injured tissues. The link between mouse…”
Get full text

Methyl Donor Deficiency Affects Fetal Programming of Gastric Ghrelin Cell Organization and Function in the Rat by Bossenmeyer-Pourié, Carine, Blaise, Sébastien, Pourié, Grégory, Tomasetto, Catherine, Audonnet, Sandra, Ortiou, Sandrine, Koziel, Violette, Rio, Marie-Christine, Daval, Jean-Luc, Guéant, Jean-Louis, Beck, Bernard

“…Methyl donor deficiency (MDD) during pregnancy influences intrauterine development. Ghrelin is expressed in the stomach of fetuses and influences fetal growth,…”
Get full text

Increased homocysteinemia is associated with beneficial effects on body weight after long-term high-protein, low-fat diet in rats by Beck, Bernard, Ph.D, Bossenmeyer-Pourié, Carine, Ph.D, Jeannesson, Elise, Ph.D, Richy, Sébastien, Ph.D, Guéant, Jean-Louis, M.D., Ph.D

“…Abstract Objective Diets rich in protein are often used for weight loss in obese patients, but their long-term effects are not fully understood. Homocysteine…”
Get full text

Differentiation and neural integration of hippocampal neuronal progenitors: Signaling pathways sequentially involved by Akchiche, Nassila, Bossenmeyer-Pourié, Carine, Pourié, Grégory, Koziel, Violette, Nédélec, Emmanuelle, Guéant, Jean-Louis, Daval, Jean-Luc

“…In the context of their potential implication in regenerative strategies, we characterized cell mechanisms underlying the fate of embryonic rat hippocampal…”
Get full text

Conditioning-like Brief Neonatal Hypoxia Improves Cognitive Function and Brain Tissue Properties with Marked Gender Dimorphism in Adult Rats by Martin, Nicolas, Pourié, Grégory, PhD, Bossenmeyer-Pourié, Carine, PhD, Jazi, Rozat, PhD, Guéant, Jean-Louis, MD, PhD, Vert, Paul, MD, Daval, Jean-Luc, PhD

“…Although recent studies have documented compensatory generation of neurons in adult brains in response to various insults, a noninjurious short episode of…”
Get full text

Late Maternal Folate Supplementation Rescues from Methyl Donor Deficiency-Associated Brain Defects by Restoring Let-7 and miR-34 Pathways by Geoffroy, Andréa, Kerek, Racha, Pourié, Grégory, Helle, Déborah, Guéant, Jean-Louis, Daval, Jean-Luc, Bossenmeyer-Pourié, Carine

“…The micronutrients folate and vitamin B12 are essential for the proper development of the central nervous system, and their deficiency during pregnancy has…”
Get full text

Brain Susceptibility to Methyl Donor Deficiency: From Fetal Programming to Aging Outcome in Rats by Hassan, Ziad, Coelho, David, Kokten, Tunay, Alberto, Jean-Marc, Umoret, Rémy, Daval, Jean-Luc, Guéant, Jean-Louis, Bossenmeyer-Pourié, Carine, Pourié, Grégory

“…Deficiencies in methyl donors, folate, and vitamin B12 are known to lead to brain function defects. Fetal development is the most studied but data are also…”
Get full text

Reduced penetrance of an eastern French mutation in ATL1 autosomal-dominant inheritance (SPG3A): extended phenotypic spectrum coupled with brain 18F-FDG PET by Hocquel, Armand, Ravel, Jean-Marie, Lambert, Laetitia, Bonnet, Céline, Banneau, Guillaume, Kol, Bophara, Tissier, Laurène, Hopes, Lucie, Meyer, Mylène, Dillier, Céline, Michaud, Maud, Lardin, Arnaud, Kaminsky, Anne-Laure, Schmitt, Emmanuelle, Liao, Liang, Zhu, François, Myriam, Bronner, Bossenmeyer-Pourié, Carine, Verger, Antoine, Renaud, Mathilde

“…ATL1 -related spastic paraplegia SPG3A is a pure form of hereditary spastic paraplegia. Rare complex phenotypes have been described, but few data concerning…”
Get full text