Search Results - "Bossé, Roger"

Phosphorylation of Serine Palmitoyltransferase Long Chain-1 (SPTLC1) on Tyrosine 164 Inhibits Its Activity and Promotes Cell Survival by Taouji, Saïd, Higa, Arisa, Delom, Frédéric, Palcy, Sandrine, Mahon, François-Xavier, Pasquet, Jean-Max, Bossé, Roger, Ségui, Bruno, Chevet, Eric

“…In BCR-ABL-expressing cells, sphingolipid metabolism is altered. Because the first step of sphingolipid biosynthesis occurs in the endoplasmic reticulum (ER),…”
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Single-Well Monitoring of Protein−Protein Interaction and Phosphorylation−Dephosphorylation Events by Arcand, Mathieu, Roby, Philippe, Bossé, Roger, Lipari, Francesco, Padrós, Jaime, Beaudet, Lucille, Marcil, Alexandre, Dahan, Sophie

“…We combined oxygen channeling assays with two distinct chemiluminescent beads to detect simultaneously protein phosphorylation and interaction events that are…”
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Homogeneous and nonradioactive high-throughput screening platform for the characterization of kinase inhibitors in cell lysates by Guenat, Sylvie, Rouleau, Nathalie, Bielmann, Christelle, Bedard, Julie, Maurer, Fabienne, Allaman-Pillet, Nathalie, Nicod, Pascal, Bielefeld-Sévigny, Martina, Beckmann, Jacques S, Bonny, Christophe, Bossé, Roger, Roduit, Raphaël

“…Protein kinases are directly implicated in many human diseases; therefore, kinase inhibitors show great promises as new therapeutic drugs. In an effort to…”
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Anterior Pituitary Hypoplasia and Dwarfism in Mice Lacking the Dopamine Transporter by Bossé, Roger, Fumagalli, Fabio, Jaber, Mohamed, Giros, Bruno, Gainetdinov, Raul R, Wetsel, William C, Missale, Cristina, Caron, Marc G

“…Deletion of the dopamine transporter (DAT) results in increased dopaminergic tone, anterior pituitary hypoplasia, dwarfism, and an inability to lactate. DAT…”
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Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers by Negroni, Luc, Taouji, Said, Arma, Daniela, Pallares-Lupon, Nestor, Leong, Kristen, Beausang, Lee Anne, Latterich, Martin, Bossé, Roger, Balabaud, Charles, Schmitter, Jean-Marie, Bioulac-Sage, Paulette, Zucman-Rossi, Jessica, Rosenbaum, Jean, Chevet, Eric

“…Proteomics-based clinical studies represent promising resources for the discovery of novel biomarkers or for unraveling molecular mechanisms underlying…”
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Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity by Pasquin, Sarah, Chehboun, Salma, Dejda, Agnieszka, Meliani, Yasmine, Savin, Virginia, Warner, Gregory J., Bosse, Roger, Tormo, Aurélie, Mayer, Gaétan, Sharma, Mukut, Sapieha, Przemyslaw, Martel, Catherine, Gauchat, Jean-François

“…The cytokines CLCF1 and CNTF are ligands for the CNTF receptor and the apolipoprotein E (ApoE) receptor sortilin. Both share structural similarities with the…”
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Current Screens Based on the AlphaScreen™ Technology for Deciphering Cell Signalling Pathways by Taouji, Saïd, Dahan, Sophie, Bossé, Roger, Chevet, Eric

“…Global deciphering of signal transduction pathways represents a new challenge of the post-genomic era. However, for the majority of these signaling pathways…”
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Systematic functional analysis of the Ras GTPase family unveils a conserved network required for anterograde protein trafficking by Caruso, Marie‐Elaine, Jenna, Sarah, Baillie, David L, Bossé, Roger, Simpson, Jeremy C., Chevet, Eric, Taouji, Saïd

“…Phylogeny is often used to compare entire families of genes/proteins. We previously showed that classification of Caenorhabditis elegans Rho GTPases on the…”
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Emerging concepts of guanine nucleotide-binding protein-coupled receptor (GPCR) function and implications for high throughput screening by Eglen, Richard M, Bosse, Roger, Reisine, Terry

“…Guanine nucleotide binding protein (G protein) coupled receptors (GPCRs) comprise one of the largest families of proteins in the human genome and are a target…”
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Characterization of the Humoral Immune Response to Porcine Epidemic Diarrhea Virus Infection under Experimental and Field Conditions Using an AlphaLISA Platform by Kimpston-Burkgren, Kay, Mora-Díaz, Juan Carlos, Roby, Philippe, Bjustrom-Kraft, Jordan, Main, Rodger, Bosse, Roger, Giménez-Lirola, Luis Gabriel

“…Coronavirus infections are a continuous threat raised time and again. With the recent emergence of novel virulent strains, these viruses can have a large…”
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The use of AlphaScreen technology in HTS: current status by Eglen, Richard M, Reisine, Terry, Roby, Philippe, Rouleau, Nathalie, Illy, Chantal, Bossé, Roger, Bielefeld, Martina

“…AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay Screen) is versatile assay technology developed to measuring analytes using a homogenous…”
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AlphaScreen kinase HTS platforms by Warner, Greg, Illy, Chantal, Pedro, Liliana, Roby, Philippe, Bossé, Roger

“…Kinases represents one of the most important family of targets in high throughput drug screening. Tyrosine kinases and serine/threonine kinases are known to…”
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Integrated cell-based platform to study EGFR activation and transactivation by Caruso, Marie-Elaine, Clément, Paule, Parent, Stéphane, Dupriez, Vincent, Bossé, Roger, Rouleau, Nathalie

“…The epidermal growth factor receptor (EGFR) pathway is one of the most deregulated molecular pathways in human epithelial cancers. Many approved drugs were…”
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A High Throughput Screen to Identify Substrates for the Ubiquitin Ligase Rsp5 by Kus, Bart, Gajadhar, Aaron, Stanger, Karen, Cho, Rob, Sun, Warren, Rouleau, Nathalie, Lee, Tammy, Chan, Donovan, Wolting, Cheryl, Edwards, Aled, Bosse, Roger, Rotin, Daniela

“…Ubiquitin-protein ligases (E3s) are implicated in various human disorders and are attractive targets for therapeutic intervention. Although most cellular…”
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Biochemical Clustering of Monomeric GTPases of the Ras Superfamily by Caruso, Marie-Elaine, Jenna, Sarah, Beaulne, Simon, Lee, Eun-Hye, Bergeron, Anne, Chauve, Cedric, Roby, Philippe, Rual, Jean-Francois, Hill, David E, Vidal, Marc, Bosse, Roger, Chevet, Eric

“…To date phylogeny has been used to compare entire families of proteins based on their nucleotide or amino acid sequence. Here we developed a novel analytical…”
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Miniaturizing screening: how low can we go today? by Bosse, Roger, Illy, Chantal, Elands, Jack, Chelsky, Daniel

“…Miniaturization in HTS is perceived as essential by pharmaceutical screening laboratories to accommodate the enormous increase in compounds and targets over…”
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The modulation of brain dopamine and GABAA receptors by estradiol: a clue for CNS changes occurring at menopause by Bossé, R, DiPaolo, T

“…1. Tardive dyskinesia is more important in postmenopausal women than men of comparable age and a peak of first episodes of schizophrenia is observed in…”
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Ovariectomy and estradiol treatment affect the dopamine transporter and its gene expression in the rat brain by Bossé, Roger, Rivest, Robert, Di Paolo, Thérèse

“…The impact of gonadal hormone withdrawal and estrogen therapy was investigated on the rat dopamine transporter (DAT). Short-term ovariectomized (ST-OVX, 2…”
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Discrimination between putative bradykinin B2 receptor subtypes in guinea pig ileum smooth muscle membranes with a selective, iodinatable, bradykinin analogue by Liebmann, C, Bossé, R, Escher, E

“…We have synthesized a potent, selective, radioiodinated bradykinin (BK) analogue with high specific radioactivity (1000-1500 Ci/mmol). The new tracer,…”
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Photoaffinity labeling of subtype 2 angiotensin receptor of human myometrium by Servant, G, Boulay, G, Bossé, R, Escher, E, Guillemette, G

“…Angiotensin II (AII) binding sites were characterized in human myometrium membrane preparations. The sites were saturable and of high affinity (Kd of 0.09 nM…”
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