Search Results - "Bosron, W F"

Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide by Quinney, S K, Sanghani, S P, Davis, W I, Hurley, T D, Sun, Z, Murry, D J, Bosron, W F

“…Capecitabine is an oral prodrug of 5-fluorouracil that is indicated for the treatment of breast and colorectal cancers. A three-step in vivo-targeted…”
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Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2 by HUMERICKHOUSE, R, LOHRBACH, K, LIN LI, BOSRON, W. F, DOLAN, M. E

“…7-Ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin (irinotecan; CPT-11) is a prodrug activated by carboxylesterase enzymes. We characterized…”
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Research advances in ethanol metabolism by Ramchandani, V.A, Bosron, W.F, Li, T.K

“…The pharmacokinetics of alcohol determines the time course of alcohol concentration in blood after the ingestion of an alcoholic beverage and the degree of…”
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Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases by Kamendulis, L M, Brzezinski, M R, Pindel, E V, Bosron, W F, Dean, R A

“…Concomitant i.v. use of cocaine and heroin ("speedballing") is prevalent among drug-abusing populations. Heroin is rapidly metabolized by sequential…”
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Kinetic Mechanism of Human Glutathione-Dependent Formaldehyde Dehydrogenase by Sanghani, Paresh C, Stone, Carol L, Ray, Bruce D, Pindel, Evgenia V, Hurley, Thomas D, Bosron, William F

“…Formaldehyde, a major industrial chemical, is classified as a carcinogen because of its high reactivity with DNA. It is inactivated by oxidative metabolism to…”
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Human Liver Carboxylesterase hCE-1: Binding Specificity for Cocaine, Heroin, and their Metabolites and Analogs by BRZEZINSKI, M. R, SPINK, B. J, DEAN, R. A, BERKMAN, C. E, CASHMAN, J. R, BOSRON, W. F

“…Purified human liver carboxylesterase (hCE-1) catalyzes the hydrolysis of cocaine to form benzoylecgonine, the deacetylation of heroin to form…”
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Genetic factors in alcohol metabolism and alcoholism by Bosron, W F, Ehrig, T, Li, T K

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Tissue distribution of cocaine methyl esterase and ethyl transferase activities: correlation with carboxylesterase protein by Dean, R A, Zhang, J, Brzezinski, M R, Bosron, W F

“…The tissue distribution of cocaine methyl esterase and ethanol-dependent ethyl transferase activities was determined in the rat and compared to the tissue…”
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Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine by Dean, R A, Christian, C D, Sample, R H, Bosron, W F

“…A new, pharmacologically active metabolite of cocaine, ethylcocaine, has been reported in individuals after concurrent use of cocaine and ethanol. Formation of…”
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Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism by Bosron, W F, Li, T K

“…It is now widely accepted that the various pharmacologic and addictive consequences of alcohol consumption are related to the tissue concentration of ethanol…”
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Structure–function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase) by Sanghani, Paresh C., Robinson, Howard, Bennett-Lovsey, Riccardo, Hurley, Thomas D., Bosron, W.F.

“…Human Class III alcohol dehydrogenase (ADH), also known as glutathione-dependent formaldehyde dehydrogenase plays an important role in the formaldehyde…”
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Catalytic efficiency of human alcohol dehydrogenases for retinol oxidation and retinal reduction by Yang, Z N, Davis, G J, Hurley, T D, Stone, C L, Li, T K, Bosron, W F

“…Mammalian alcohol dehydrogenase (ADH) is thought to be involved in the reversible oxidation of vitamin A or retinol to retinal for retinoic acid synthesis…”
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Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant by Crabb, D W, Edenberg, H J, Bosron, W F, Li, T K

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Effects of ethanol on cocaine metabolism: formation of cocaethylene and norcocaethylene by Dean, R A, Harper, E T, Dumaual, N, Stoeckel, D A, Bosron, W F

“…The coabuse of cocaine and ethanol occurs with high frequency and increases the risk of cocaine-related morbidity and mortality. The mechanisms mediating the…”
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Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions by Hurley, T D, Bosron, W F, Hamilton, J A, Amzel, L M

“…The three-dimensional structure of human beta 1 beta 1 alcohol dehydrogenase (ADH; EC 1.1.1.1) complexed with NAD+ has been determined by x-ray crystallography…”
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Stereospecific Oxidation of Secondary Alcohols by Human Alcohol Dehydrogenases by Stone, C L, Li, T K, Bosron, W F

“…The human liver αα alcohol dehydrogenase exhibits a different substrate specificity and stereospecificity for secondary alcohols than the human β1β1, and -γ1γ1…”
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Amino acid substitutions at position 47 of human beta 1 beta 1 and beta 2 beta 2 alcohol dehydrogenases affect hydride transfer and coenzyme dissociation rate constants by Stone, C L, Bosron, W F, Dunn, M F

“…Human liver alcohol dehydrogenase isoenzymes beta 1 beta 1 and beta 2 beta 2, in which position 47 in the coenzyme binding domain is an arginine or histidine,…”
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Purification and partial amino acid sequence of a high-activity human stomach alcohol dehydrogenase by Stone, C L, Thomasson, H R, Bosron, W F, Li, T K

“…To understand the relative importance of alcohol dehydrogenase (ADH) isoenzymes in gastric ethanol metabolism, a stomach-specific ADH (sigma-ADH) was purified…”
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Cloning and sequencing of CDNA encoding the complete mouse liver alcohol dehydrogenase by Edenberg, H.J, Zhang, K, Fong, K, Bosron, W.F, Li, T.K

“…The main ethanol-active alcohol dehydrogenase (ADH; alcohol:NAD+oxidoreductase, EC 1.1.1.1) in mouse liver (ADH-AA) is similar in catalytic and molecular…”
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Expression and kinetic characterization of variants of human beta 1 beta 1 alcohol dehydrogenase containing substitutions at amino acid 47 by Hurley, T D, Edenberg, H J, Bosron, W F

“…Arg-47 of human beta 1 beta 1 alcohol dehydrogenase has been replaced with Lys, His, Gln, and Gly by site-directed mutagenesis. The mutated enzymes were…”
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