Search Results - "Bosques, Carlos J."

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity by Washburn, Nathaniel, Schwab, Inessa, Ortiz, Daniel, Bhatnagar, Naveen, Lansing, Jonathan C., Medeiros, Amy, Tyler, Steven, Mekala, Divya, Cochran, Edward, Sarvaiya, Hetal, Garofalo, Kevin, Meccariello, Robin, Meador, James W., Rutitzky, Laura, Schultes, Birgit C., Ling, Leona, Avery, William, Nimmerjahn, Falk, Manning, Anthony M., Kaundinya, Ganesh V., Bosques, Carlos J.

“…Despite the beneficial therapeutic effects of intravenous immunoglobulin (IVIg) in inflammatory diseases, consistent therapeutic efficacy and potency remain…”
Get full text

Engineered IgG1-Fc Molecules Define Valency Control of Cell Surface Fcγ Receptor Inhibition and Activation in Endosomes by Bailey, Elizabeth M, Choudhury, Amit, Vuppula, Harika, Ortiz, Daniel F, Schaeck, John, Manning, Anthony M, Bosques, Carlos J, Hoppe, Adam D

“…The inhibition of Fcγ receptors (FcγR) is an attractive strategy for treating diseases driven by IgG immune complexes (IC). Previously, we demonstrated that an…”
Get full text

High-resolution physicochemical characterization of different intravenous immunoglobulin products by Washburn, Nathaniel, Meccariello, Robin, Hu, Shaohui, Hains, Maurice, Bhatnagar, Naveen, Sarvaiya, Hetal, Kapoor, Bulbul, Schaeck, John, Pino, Ignacio, Manning, Anthony, Lansing, Jonathan C, Bosques, Carlos J

“…Intravenous immunoglobulin (IVIg) is a complex mixture drug comprising diverse immunoglobulins and non-IgG proteins purified from the plasma of thousands of…”
Get full text

Inhibitory Fc-Gamma IIb Receptor Signaling Induced by Multivalent IgG-Fc Is Dependent on Sialylation by Beneduce, Christopher, Nguyen, Stephanie, Washburn, Nathaniel, Schaeck, John, Meccariello, Robin, Holte, Kimberly, Ortiz, Daniel, Manning, Anthony M., Bosques, Carlos J., Kurtagic, Elma

“…Immunoglobulin (IgG) Fc glycosylation has been shown to be important for the biological activity of antibodies. Fc sialylation is important for the…”
Get full text

Chondroitinase ABC I from Proteus vulgaris: cloning, recombinant expression and active site identification by Prabhakar, Vikas, Capila, Ishan, Bosques, Carlos J, Pojasek, Kevin, Sasisekharan, Ram

“…GalAGs (galactosaminoglycans) are one subset of the GAG (glycosaminoglycan) family of chemically heterogeneous polysaccharides that are involved in a wide…”
Get full text

Effects of Glycosylation on Peptide Conformation:  A Synergistic Experimental and Computational Study by Bosques, Carlos J, Tschampel, Sarah M, Woods, Robert J, Imperiali, Barbara

“…Asparagine-linked glycosylation, the co-translational covalent attachment of carbohydrates to asparagine side chains, has a major effect on the folding,…”
Get full text

Biochemical characterization of the chondroitinase ABC I active site by Prabhakar, Vikas, Raman, Rahul, Capila, Ishan, Bosques, Carlos J, Pojasek, Kevin, Sasisekharan, Ram

“…cABC I (chondroitinase ABC I) from Proteus vulgaris is a GalAG (galactosaminoglycan) depolymerizing lyase that cleaves its substrates at the glycosidic bond…”
Get full text

The Interplay of Glycosylation and Disulfide Formation Influences Fibrillization in a Prion Protein Fragment by Bosques, Carlos J., Imperiali, Barbara

“…It is now accepted that the structural transition from cellular prion protein (PrPC) to proteinase K-resistant prion protein scrapie (PrPSc) is the major event…”
Get full text

Renal Injury Is a Consistent Finding in Dutch Belted Rabbits Experimentally Infected with Enterohemorrhagic Escherichia coli by García, Alexis, Bosques, Carlos J., Wishnok, John S., Feng, Yan, Karalius, Brad J., Butterton, Joan R., Schauer, David B., Rogers, Arlin B., Fox, James G.

“…Enterohemorrhagic Escherichia coli (EHEC) produces Shiga toxin (Stx) and causes renal disease in humans. Dutch Belted (DB) rabbits naturally infected with EHEC…”
Get full text

The Catalytic Machinery of Chondroitinase ABC I Utilizes a Calcium Coordination Strategy to Optimally Process Dermatan Sulfate by Prabhakar, Vikas, Capila, Ishan, Raman, Rahul, Srinivasan, Aravind, Bosques, Carlos J, Pojasek, Kevin, Wrick, Michael A, Sasisekharan, Ram

“…The chondroitinases are bacterial lyases that specifically cleave chondroitin sulfate and/or dermatan sulfate glycosaminoglycans. One of these enzymes,…”
Get full text

Fc-Gamma Receptors: Attractive Targets for Autoimmune Drug Discovery Searching for Intelligent Therapeutic Designs by Bosques, Carlos J, Manning, Anthony M

“…Abstract Auto-antibody immune complexes (ICs) mediate pathogenesis in multiple autoimmune diseases direct interference with target function, complement…”
Get full text

Characterization of Endogenous Human FcγRIII by Mass Spectrometry Reveals Site, Allele and Sequence Specific Glycosylation[S] by Washburn, Nathaniel, Meccariello, Robin, Duffner, Jay, Getchell, Kristen, Holte, Kimberly, Prod'homme, Thomas, Srinivasan, Karunya, Prenovitz, Robert, Lansing, Jonathan, Capila, Ishan, Kaundinya, Ganesh, Manning, Anthony M., Bosques, Carlos J.

“…Characterization of endogenous FcγRIII glycosylation from healthy donors with different FcγRIIIb genotypes reveals site specific, and allele specific…”
Get full text

Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors by Ortiz, Daniel F, Lansing, Jonathan C, Rutitzky, Laura, Kurtagic, Elma, Prod'homme, Thomas, Choudhury, Amit, Washburn, Nathaniel, Bhatnagar, Naveen, Beneduce, Christopher, Holte, Kimberly, Prenovitz, Robert, Child, Matthew, Killough, Jason, Tyler, Steven, Brown, Julia, Nguyen, Stephanie, Schwab, Inessa, Hains, Maurice, Meccariello, Robin, Markowitz, Lynn, Wang, Jing, Zouaoui, Radouane, Simpson, Allison, Schultes, Birgit, Capila, Ishan, Ling, Leona, Nimmerjahn, Falk, Manning, Anthony M, Bosques, Carlos J

“…Autoantibody immune complex (IC) activation of Fcγ receptors (FcγRs) is a common pathogenic hallmark of multiple autoimmune diseases. Given that the IC…”
Get more information

Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins by Venkataraman, Ganesh, Bosques, Carlos J, Collins, Brian E, Meador, James W, Sarvaiya, Hetal, Murphy, Jennifer L, DelloRusso, Guy, Bulik, Dorota A, Hsu, I-Hsuan, Washburn, Nathaniel, Sipsey, Sandra F, Myette, James R, Raman, Rahul, Shriver, Zachary, Sasisekharan, Ram

Get full text

Profiling the Glycoforms of the Intact α Subunit of Recombinant Human Chorionic Gonadotropin by High-Resolution Capillary Electrophoresis−Mass Spectrometry by Thakur, Dipak, Rejtar, Tomas, Karger, Barry L, Washburn, Nathaniel J, Bosques, Carlos J, Gunay, Nur S, Shriver, Zachary, Venkataraman, Ganesh

“…With the rapid growth of complex heterogeneous biological molecules, effective techniques that are capable of rapid characterization of biologics are essential…”
Get full text

A simple assay to probe disease-associated enzyme activity using glycosaminoglycan-assisted synthesized gold nanoparticles by Ban, Zhihui, Bosques, Carlos J, Sasisekharan, Ram

“…A simple assay to probe disease-associated enzyme activity using glycosaminoglycan-assisted synthesized gold nanoparticles is reported…”
Get more information

Circulating Markers of Inflammation Persist in Children and Adults With Giant Aneurysms After Kawasaki Disease by Lech, Miroslaw, Guess, Jamey, Duffner, Jay, Oyamada, Jun, Shimizu, Chisato, Hoshino, Shinsuke, Farutin, Victor, Bulik, Dorota A, Gutierrez, Bryan, Sarvaiya, Hetal, Kapoor, Bulbul, Koppes, Laura, Saldova, Radka, Stockmann, Henning, Albrecht, Simone, McManus, Ciara, Rudd, Pauline M, Kaundinya, Ganesh V, Manning, Anthony M, Bosques, Carlos J, Kahn, Andrew M, Daniels, Lori B, Gordon, John B, Tremoulet, Adriana H, Capila, Ishan, Gunay, Nur Sibel, Ling, Leona E, Burns, Jane C

“…The sequelae of Kawasaki disease (KD) vary widely with the greatest risk for future cardiovascular events among those who develop giant coronary artery…”
Get full text

Photolytic Control of Peptide Self-Assembly by Bosques, Carlos J, Imperiali, Barbara

“…Herein, we present a methodology that allows for the temporal control of fibrillization of amyloidogenic peptides. This general approach implements a…”
Get full text

The sweet side of biomarker discovery by Bosques, Carlos J, Raguram, S, Sasisekharan, Ram

“…Glycans are involved in each and every aspect of tumor progression, from cellular proliferation to angiogenesis and metastasis, and in theory could be used to…”
Get full text

Non-aqueous encapsulation of excipient-stabilized spray-freeze dried BSA into poly(lactide- co-glycolide) microspheres results in release of native protein by Carrasquillo, Karen G, Stanley, Ann M, Aponte-Carro, Juan C, De Jésus, Patricia, Costantino, Henry R, Bosques, Carlos J, Griebenow, Kai

“…Encapsulation of the model protein bovine serum albumin (BSA) into poly( d, l lactide- co-glycolide) (PLG) microspheres was performed by a non-aqueous…”
Get full text