Benchmarking recent national practice in rectal cancer treatment with landmark randomized controlled trials

Aim A Snapshot study design eliminates changes in treatment and outcome over time. This population based Snapshot study aimed to determine current practice and outcome of rectal cancer treatment with published landmark randomized controlled trials as a benchmark. Method In this collaborative researc...

Full description

Saved in:

Bibliographic Details
Published in:	Colorectal disease Vol. 19; no. 6; pp. O219 - O231
Main Authors:	Borstlap, WAA, Deijen, CL, Dulk, M, Bonjer, HJ, Tanis, P. J., Aalbers, A, Acherman, Y, Geusau, B Alting, Amelung, F, Aukema, TS, Basha, S, Bastiaansen, AJNM, Belgers, E, Bleeker, W, Blok, J, Bosker, RJI, Bosmans, JW, Bruin, S, Bruns, ERJ, Burbach, JPM, Clermonts, S, Compaan, C, Darbyshire, T, Graaf, EJR, Wilt, JHW, Wolde, J, Boer, FC, Demirkiran, A, Duijvendijk, P, Dunker, MS, Ferenschild, F, Foppen, JW, Furnée, EJB, Gooszen, JAH, Govaert, JA, Van Grevenstein, WMU, Harst, E, Havenga, K, Heeren, JF, Hogendoorn, W, Huijbers, A, Karthaus, EG, Keijzer, A, Lamme, B, Lange, JF, Marres, CC, Meerdink, M, Mieog, JS, Nonner, J, Oostdijk, M, Peeters, KCMJC, Poortman, P, Raber, M, Reiber, BMM, Renger, RJ, Rossem, CC, Rutten, HJ, Rutten, A, Schoonderwoerd, L, Schouten, N, Schreuder, AM, Schreurs, WH, Simkens, GA, Smakman, N, Snijders, HS, Bilgen, EJ Spillenaar, Steup, WH, Steur, C, Stortelder, E, Straatman, J, Sietses, C, hoeve, HG, Riele, WW, Toorenvliet, BR, Tuynman, JB, Bastelaar, J, beek, SC, Ven, AWH, Berg, C, Hagen, SJ, hul, R, Schelling, G, Spek, A, Wielen, N, Geloven, AAW, kessel, C, Tets, WF, Westreenen, HL, Veltkamp, S, Vijfhuize, S, Vogelaar, FJ, Westerterp, ME, Wevers, K, Wiering, B, Witjes, AC, Yauw, STK, Zeestraten, EC, Zimmerman, DD, Zwieten, T
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-06-2017
Subjects:	Aged Aged, 80 and over Benchmarking Cancer therapies Chemoradiotherapy - methods Chemoradiotherapy - statistics & numerical data Clinical trials Color Cross-Sectional Studies Disease-Free Survival Female Health risk assessment Humans Intersectoral Collaboration Laparoscopy Male Margins of Excision Medical Audit Middle Aged Neoplasm Recurrence, Local - etiology Netherlands oncologic outcomes Population studies Prospective Studies Randomization Randomized Controlled Trials as Topic - statistics & numerical data Rectal cancer Rectal Neoplasms - therapy Rectum Registries Retrospective Studies snapshot study Surgery Survival Transanal Endoscopic Microsurgery - methods Transanal Endoscopic Microsurgery - statistics & numerical data Treatment Outcome Rectal cancer oncologic outcomes snapshot study
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Aim A Snapshot study design eliminates changes in treatment and outcome over time. This population based Snapshot study aimed to determine current practice and outcome of rectal cancer treatment with published landmark randomized controlled trials as a benchmark. Method In this collaborative research project, the dataset of the Dutch Surgical Colorectal Audit was extended with additional treatment and long‐term outcome data. All registered patients who underwent resection for rectal cancer in 2011 were eligible. Baseline characteristics and outcome were evaluated against the results of the Dutch TME trial and the COLOR II trial from which the original datasets were obtained. Results A total of 71 hospitals participated, and data were completed for 2102 out of the potential 2633 patients (79.8%). Median follow‐up was 41 (interquartile range 25–47) months. Overall circumferential resection margin (CRM) involvement was 9.3% in the Snapshot cohort and 18.5% in the Dutch TME trial. CRM positivity after laparoscopic resection was 7.8% in the Snapshot and 9.5% in the COLOR II trial. Three‐year overall local recurrence rate in the Snapshot was 5.9%, with a disease‐free survival of 67.1% and overall survival of 79.5%. Benchmarking with the randomized controlled trials revealed an overall favourable long‐term outcome of the Snapshot cohort. Conclusion This study showed that current rectal cancer care in a large unselected Dutch population is of high quality, with less positive CRM since the TME trial and oncologically safe implementation of minimally invasive surgery after the COLOR II trial.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1462-8910 1463-1318
DOI:	10.1111/codi.13644