Search Results - "Bosma, Gayle C"

catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination by Kiefer, Kerstin, Oshinsky, Jennifer, Kim, Jiyoon, Nakajima, Pamela B, Bosma, Gayle C, Bosma, Melvin J

“…The joining of DNA ends during Ig class-switch recombination (CSR) is thought to involve the same nonhomologous end-joining pathway as used in V(D)J…”
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A severe combined immunodeficiency mutation in the mouse by Bosma, Gayle C, Custer, R. Philip, Bosma, Melvin J

“…The most debilitating human lymphoid deficiency disease, known as severe combined immunodeficiency (SCID), impairs the differentiation of both T and B…”
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Two Distinct Populations of H Chain-Edited B Cells Show Differential Surrogate L Chain Dependence by Nakajima, Pamela B, Kiefer, Kerstin, Price, Amy, Bosma, Gayle C, Bosma, Melvin J

“…Developing autoreactive B cells may edit (change) their specificity by secondary H or L chain gene rearrangement. Recently, using mice hemizygous for a…”
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DNA-dependent protein kinase activity is not required for immunoglobulin class switching by Bosma, Gayle C, Kim, Jiyoon, Urich, Teresa, Fath, Donna M, Cotticelli, Maria G, Ruetsch, Norman R, Radic, Marko Z, Bosma, Melvin J

“…Class switch recombination (CSR), similar to V(D)J recombination, is thought to involve DNA double strand breaks and repair by the nonhomologous end-joining…”
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Antigen Receptor Editing in Anti-DNA Transitional B Cells Deficient for Surface IgM by Kiefer, Kerstin, Nakajima, Pamela B, Oshinsky, Jennifer, Seeholzer, Steven H, Radic, Marko, Bosma, Gayle C, Bosma, Melvin J

“…In response to encounter with self-Ag, autoreactive B cells may undergo secondary L chain gene rearrangement (receptor editing) and change the specificity of…”
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Development of Functional B Cells in a Line of SCID Mice with Transgenes Coding for Anti-Double-Stranded DNA Antibody by Bosma, Gayle C, Oshinsky, Jennifer, Kiefer, Kerstin, Nakajima, Pamela B, Charan, Deepshika, Congelton, Cecil, Radic, Marko, Bosma, Melvin J

“…Deletion or inactivation of anti-self (DNA) B cells has been reported in non-autoimmune mice bearing Ig transgenes that code for Abs with specificity for dsDNA…”
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Extended duration of DH-JH rearrangement in immunoglobulin heavy chain transgenic mice: implications for regulation of allelic exclusion by Chang, Y, Bosma, M J, Bosma, G C

“…Here we show that suppression of VH-DJH rearrangement in mice bearing a mu heavy (H) chain transgene (mu-tg mice) is associated with an extended period of…”
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Differential Effect of an Ig μ Transgene on Development of Pre-B Cells in Fetal and Adult SCID Mice by Bosma, Gayle C., Chang, Yung, Karasuyama, Hajime, Bosma, Melvin J.

“…Progression of pro-B lymphocytes to the pre-B stage depends on the expression of a pre-B cell receptor (pre-BCR), consisting of an Ig μ H chain, Ig surrogate…”
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Two distinct populations of H chain edited B cells show differential surrogate L chain dependence1 by Nakajima, Pamela B., Kiefer, Kerstin, Price, Amy, Bosma, Gayle C., Bosma, Melvin J.

“…Developing autoreactive B cells may edit (change) their specificity by secondary H or L chain gene rearrangement. Recently, using mice hemizygous for a…”
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Unexpected Rearrangement and Expression of the Immunoglobulin λ1 Locus in Scid Mice by Ruetsch, Norman R., Bosma, Gayle C., Bosma, Melvin J.

“…In severe combined immunodeficient (scid) mice, V(D)J recombination is severely impaired due to a recessive mutation (scid). Thus, we were surprised to find in…”
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Chronic suppression of immunoglobulin allotype production in adult congenic mice by BOSMA, MELVIN J, BOSMA, GAYLE C

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Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required by Berger, M A, Davé, V, Rhodes, M R, Bosma, G C, Bosma, M J, Kappes, D J, Wiest, D L

“…Maturation of immature CD4-CD8- (DN) thymocytes to the CD4+CD8+ (DP) stage of development is driven by signals transduced through a pre-T cell receptor (TCR)…”
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The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination by Lieber, M R, Hesse, J E, Lewis, S, Bosma, G C, Rosenberg, N, Mizuuchi, K, Bosma, M J, Gellert, M

“…Pre-B and pre-T cell lines from mutant mice with severe combined immune deficiency (scid mice) were transfected with plasmids that contained recombination…”
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Evidence of functional lymphocytes in some (leaky) scid mice by BOSMA, G. C, FRIED, M, CUSTER, R. P, CARROLL, A, GIBSON, D. M, BOSMA, M. J

“…Although the majority of severe combined immune deficiency (scid) mice lack functional lymphocytes, some (2-23%) appear to develop a limited number of B and T…”
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The Influence of Pupal Age on Sensitivity to Radiation by Ducoff, H. S., Bosma, Gayle C.

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Development of B cells in scid mice with immunoglobulin transgenes: Implications for the Control of V(D)J recombination by Chang, Yung, Bosma, Gayle C., Bosma, Melvin J.

“…The inability of scid pro-B cells to progress to the pre-B and B cell stages is believed to be caused by a defective recombinase activity that fails to resolve…”
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Transplantable Progenitors of Natural Killer Cells are Distinct from Those of T and B Lymphocytes by Hackett, John, Bosma, Gayle C., Bosma, Melvin J., Bennett, Michael, Kumar, Vinay

“…We have utilized a mouse mutant (C.B-17 scid) that lacks functional T and B lymphocytes to examine the relationship among transplantable progenitors of natural…”
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Limited clonal diversity of serum immunoglobulin in leaky scid mice by Gibson, D M, Bosma, G C, Bosma, M J

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Reconstitution of scid mice by injection of varying numbers of normal fetal liver cells into scid neonates by Bosma, G C, Gibson, D M, Custer, R P, Bosma, M J

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Congenic mouse strains: the expression of a hidden immunoglobulin allotype in a congenic partner strain of BALB-c mice by Bosma, M J, Bosma, G C

“…This paper derives from the unexpected observations of the "wrong immunoglobulin allotype" in a congenic partner strain of BALB/c mice from the Institute of…”
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