Search Results - "Bosma, GC"

DNA-dependent protein kinase activity is not required for immunoglobulin class switching by Bosma, Gayle C, Kim, Jiyoon, Urich, Teresa, Fath, Donna M, Cotticelli, Maria G, Ruetsch, Norman R, Radic, Marko Z, Bosma, Melvin J

“…Class switch recombination (CSR), similar to V(D)J recombination, is thought to involve DNA double strand breaks and repair by the nonhomologous end-joining…”
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Development of Functional B Cells in a Line of SCID Mice with Transgenes Coding for Anti-Double-Stranded DNA Antibody by Bosma, Gayle C, Oshinsky, Jennifer, Kiefer, Kerstin, Nakajima, Pamela B, Charan, Deepshika, Congelton, Cecil, Radic, Marko, Bosma, Melvin J

“…Deletion or inactivation of anti-self (DNA) B cells has been reported in non-autoimmune mice bearing Ig transgenes that code for Abs with specificity for dsDNA…”
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Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required by Berger, M A, Davé, V, Rhodes, M R, Bosma, G C, Bosma, M J, Kappes, D J, Wiest, D L

“…Maturation of immature CD4-CD8- (DN) thymocytes to the CD4+CD8+ (DP) stage of development is driven by signals transduced through a pre-T cell receptor (TCR)…”
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The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination by Lieber, M R, Hesse, J E, Lewis, S, Bosma, G C, Rosenberg, N, Mizuuchi, K, Bosma, M J, Gellert, M

“…Pre-B and pre-T cell lines from mutant mice with severe combined immune deficiency (scid mice) were transfected with plasmids that contained recombination…”
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Unexpected Rearrangement and Expression of the Immunoglobulin lambda 1 Locus in Scid Mice by Ruetsch, N R, Bosma, G C, Bosma, MJ

“…In severe combined immunodeficient (scid) mice, V(D)J recombination is severely impaired due to a recessive mutation (scid). Thus, we were surprised to find in…”
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Evidence of functional lymphocytes in some (leaky) scid mice by BOSMA, G. C, FRIED, M, CUSTER, R. P, CARROLL, A, GIBSON, D. M, BOSMA, M. J

“…Although the majority of severe combined immune deficiency (scid) mice lack functional lymphocytes, some (2-23%) appear to develop a limited number of B and T…”
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Extended duration of DH-JH rearrangement in immunoglobulin heavy chain transgenic mice: implications for regulation of allelic exclusion by Chang, Y, Bosma, M J, Bosma, G C

“…Here we show that suppression of VH-DJH rearrangement in mice bearing a mu heavy (H) chain transgene (mu-tg mice) is associated with an extended period of…”
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A severe combined immunodeficiency mutation in the mouse by Bosma, Gayle C, Custer, R. Philip, Bosma, Melvin J

“…The most debilitating human lymphoid deficiency disease, known as severe combined immunodeficiency (SCID), impairs the differentiation of both T and B…”
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Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms by Custer, RP, Bosma, GC, Bosma, MJ

“…Histologic findings in mice with severe combined immunodeficiency (SCID) were remarkably uniform, consisting of lymphopenia, a rudimentary thymic medulla…”
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A T cell-independent mechanism of macrophage activation by interferon- gamma by Bancroft, GJ, Schreiber, RD, Bosma, GC, Bosma, MJ, Unanue, ER

“…A primary interest in immunity to intracellular pathogenic microorganisms and tumors is to understand the mechanisms by which macrophages are activated for…”
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Development of B cells in scid mice with immunoglobulin transgenes: Implications for the Control of V(D)J recombination by Chang, Yung, Bosma, Gayle C., Bosma, Melvin J.

“…The inability of scid pro-B cells to progress to the pre-B and B cell stages is believed to be caused by a defective recombinase activity that fails to resolve…”
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Differential Effect of an Ig μ Transgene on Development of Pre-B Cells in Fetal and Adult SCID Mice by Bosma, Gayle C., Chang, Yung, Karasuyama, Hajime, Bosma, Melvin J.

“…Progression of pro-B lymphocytes to the pre-B stage depends on the expression of a pre-B cell receptor (pre-BCR), consisting of an Ig μ H chain, Ig surrogate…”
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Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease by Dorshkind, K, Keller, GM, Phillips, RA, Miller, RG, Bosma, GC, O'Toole, M, Bosma, MJ

“…Cells from mice with severe combined immunodeficiency disease (SCID) were tested in assays that measure myeloid and lymphoid function. Results showed that…”
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Regulation of macrophage Ia expression in mice with severe combined immunodeficiency: induction of Ia expression by a T cell-independent mechanism by Bancroft, GJ, Bosma, MJ, Bosma, GC, Unanue, ER

“…We have studied the expression of Ia molecules by macrophages from mice with severe combined immunodeficiency (CB-17 scid) that lack demonstrable T cell and B…”
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The mouse mutation severe combined immune deficiency (scid) is on chromosome 16 by BOSMA, G. C, DAVISSON, M. T, RUETSCH, N. R, SWEET, H. O, SHULTZ, L. D, BOSMA, M. J

“…To ascertain the chromosomal location of scid , different mouse linkage testing stocks that express one or more marker genes of known chromosomal location were…”
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Transcription of unrearranged antigen receptor genes in scid mice by Schuler, W., Schuler, A., Lennon, G. G., Bosma, G. C., Bosma, M. J.

“…The scid mouse mutant is severely deficient in lymphocytes; cells of the B or T lymphocyte lineage cannot be detected by either serological or functional…”
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Limited clonal diversity of serum immunoglobulin in leaky scid mice by Gibson, D M, Bosma, G C, Bosma, M J

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Pathology of Listeria infection in murine severe combined immunodeficiency. A study by immunohistochemistry and electron microscopy by Deschryver-Kecskemeti, K, Bancroft, G J, Bosma, G C, Bosma, M J, Unanue, E R

“…Mice bearing the scid mutation lack functional T and B lymphocytes and partially resist infection with the intracellular pathogen Listeria monocytogenes. In…”
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Early B-cell precursors in scid mice: normal numbers of cells transformable with Abelson murine leukemia virus (A-MuLV) by Fulop, G M, Bosma, G C, Bosma, M J, Phillips, R A

“…scid mice lack detectable B and T lymphocytes; there are no typical pre-B cells as defined by c mu and surface markers in their bone marrow and their thymus…”
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Reconstitution of scid mice by injection of varying numbers of normal fetal liver cells into scid neonates by Bosma, G C, Gibson, D M, Custer, R P, Bosma, M J

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