Search Results - "Boslett, James"

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline by Tarragó, Mariana G., Chini, Claudia C.S., Kanamori, Karina S., Warner, Gina M., Caride, Ariel, de Oliveira, Guilherme C., Rud, Micaela, Samani, Adrienne, Hein, Kyaw Z., Huang, Runqing, Jurk, Diana, Cho, Dong Seong, Boslett, James J., Miller, Jordan D., Zweier, Jay L., Passos, João F., Doles, Jason D., Becherer, David J., Chini, Eduardo N.

“…Aging is characterized by the development of metabolic dysfunction and frailty. Recent studies show that a reduction in nicotinamide adenine dinucleotide…”
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Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall by Liu, Xiaoping, El-Mahdy, Mohamed A., Boslett, James, Varadharaj, Saradhadevi, Hemann, Craig, Abdelghany, Tamer M., Ismail, Raed S., Little, Sean C., Zhou, Danlei, Thuy, Le Thi Thanh, Kawada, Norifumi, Zweier, Jay L.

“…The identity of the specific nitric oxide dioxygenase (NOD) that serves as the main in vivo regulator of O 2 -dependent NO degradation in smooth muscle remains…”
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SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients by Klimstra, William B, Tilston-Lunel, Natasha L, Nambulli, Sham, Boslett, James, McMillen, Cynthia M, Gilliland, Theron, Dunn, Matthew D, Sun, Chengun, Wheeler, Sarah E, Wells, Alan, Hartman, Amy L, McElroy, Anita K, Reed, Douglas S, Rennick, Linda J, Duprex, W Paul

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), emerged at the end of 2019 and by…”
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Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides by Boslett, James, Helal, Moustafa, Chini, Eduardo, Zweier, Jay L.

“…Following the onset of ischemia/reperfusion (I/R), CD38 activation occurs and is associated with depletion of NAD(P)(H) in the heart as well as myocardial…”
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Effect of blood collection tube containing protease inhibitors on the pre‐analytical stability of Alzheimer's disease plasma biomarkers by Chen, Yijun, Zeng, Xuemei, Diaz, Jihui L., Sehrawat, Anuradha, Lafferty, Tara K., Boslett, James J., Klunk, William E., Pascoal, Tharick A., Villemagne, Victor L., Cohen, Ann D., Lopez, Oscar I., Yates, Nathan A., Karikari, Thomas K.

“…The reliability of plasma biomarkers of Alzheimer's disease (AD) can be compromised by protease‐induced degradation. This can limit the feasibility of…”
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Development of a fast‐scan EPR imaging system for highly accelerated free radical imaging by Samouilov, Alexandre, Ahmad, Rizwan, Boslett, James, Liu, Xiaoping, Petryakov, Sergey, Zweier, Jay L.

“…Purpose In continuous wave EPR imaging, the acquisition of high‐quality images was previously limited by the requisite long acquisition times of each image…”
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Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart by Reyes, Levy A., Boslett, James, Varadharaj, Saradhadevi, De Pascali, Francesco, Hemann, Craig, Druhan, Lawrence J., Ambrosio, Giuseppe, El-Mahdy, Mohamed, Zweier, Jay L.

“…In the postischemic heart, coronary vasodilation is impaired due to loss of endothelial nitric oxide synthase (eNOS) function. Although the eNOS cofactor…”
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Mechanism by Which PF-3758309, a Pan Isoform Inhibitor of p21-Activated Kinases, Blocks Reactivation of HIV-1 Latency by Vargas, Benni, Boslett, James, Yates, Nathan, Sluis-Cremer, Nicolas

“…The "block and lock" strategy is one approach that might elicit a sterilizing cure for HIV-1 infection. The "block" refers to a compound's ability to inhibit…”
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Post‐ischemic Cardiac Protection by NADPH Supplementation or CD38 Inhibition is Dependent on Endothelial Nitric Oxide Synthase (eNOS) by Boslett, James, Zweier, Jay L.

“…Introduction Recently, we showed that CD38 activation in myocardial ischemia/reperfusion (I/R) injury causes depletion of the NADP(H) pool of the heart with…”
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Characterization of CD38 mRNA, Protein, and Enzyme Activity in the Cell Types of the Heart by Boslett, James, Zweier, Jay L.

“…Introduction Recently, we showed that NAD(P) + ‐hydrolyzing CD38 is activated in myocardial ischemia/reperfusion (I/R) injury, leading to depletion of its…”
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Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia-reoxygenation triggering NAD(P)H depletion by Boslett, James, Hemann, Craig, Christofi, Fedias L, Zweier, Jay L

“…The NAD(P) -hydrolyzing enzyme CD38 is activated in the heart during the process of ischemia and reperfusion, triggering NAD(P)(H) depletion. However, the…”
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Inhibition of CD38 with the Thiazoloquin(az)olin(on)e 78c Protects the Heart against Postischemic Injury by Boslett, James, Reddy, Nikhil, Alzarie, Yasmin A, Zweier, Jay L

“…Inhibition of and genetic deletion of the NAD(P) hydrolase [NAD(P)ase] CD38 have been shown to protect against ischemia/reperfusion (I/R) injury in rat and…”
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Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H) by Boslett, James, Hemann, Craig, Zhao, Yong Juan, Lee, Hon-Cheung, Zweier, Jay L

“…We recently showed that ischemia/reperfusion (I/R) of the heart causes CD38 activation with resultant depletion of the cardiac NADP(H) pool, which is most…”
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Bacterial Pyocyanin Inducible KRT6A Accelerates Closure of Epithelial Defect Under Conditions of Mitochondrial Dysfunction by Ghatak, Subhadip, Hemann, Craig, Boslett, James, Singh, Kanhaiya, Sharma, Anu, El Masry, Mohamed S., Abouhashem, Ahmed Safwat, Ghosh, Nandini, Mathew-Steiner, Shomita S, Roy, Sashwati, Zweier, Jay L., Sen, Chandan K.

“…Repair of epithelial defect is complicated by infection and related metabolites. Pyocyanin is one such metabolite which is secreted during Pseudomonas…”
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Bacterial Pyocyanin Inducible Keratin 6A Accelerates Closure of Epithelial Defect under Conditions of Mitochondrial Dysfunction by Ghatak, Subhadip, Hemann, Craig, Boslett, James, Singh, Kanhaiya, Sharma, Anu, El Masry, Mohamed S., Abouhashem, Ahmed Safwat, Ghosh, Nandini, Mathew-Steiner, Shomita S., Roy, Sashwati, Zweier, Jay L., Sen, Chandan K.

“…Repair of epithelial defect is complicated by infection and related metabolites. Pyocyanin (PYO) is one such metabolite that is secreted during Pseudomonas…”
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Abstract 19525: Knockout of CD38 Preserves Endothelial Function in the Postischemic Heart through Reduced Nicotinamide Adenine Dinucleotide Phosphate Salvage by Boslett, James J, Chini, Eduardo N, Zweier, Jay

“…Abstract only Introduction: Cardiac ischemia/reperfusion (I/R) injury causes dysfunction in the coronary endothelium, resulting in loss of vascular relaxation…”
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Acute BH4 depletion leads to a loss of myocardial protection conferred by cardiac‐specific overexpression of inducible nitric oxide synthase in mice (547.11) by Boslett, James, Barga, Elizabeth, Kotwal, Ameya, Choppara, Bhavana, Zweier, Jay

“…Many studies have shown that cardiac overexpression of NOS enzymes can lead to myocardial protection against ischemia/reperfusion (I/R) injury. However, none…”
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Acute BH 4 depletion leads to a loss of myocardial protection conferred by cardiac‐specific overexpression of inducible nitric oxide synthase in mice (547.11) by Boslett, James, Barga, Elizabeth, Kotwal, Ameya, Choppara, Bhavana, Zweier, Jay

“…Abstract only Many studies have shown that cardiac overexpression of NOS enzymes can lead to myocardial protection against ischemia/reperfusion (I/R) injury…”
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Luteolinidin, a naturally occurring flavonoid, decreases ischemia/reperfusion injury through inhibition of CD38 and preservation of NADPH and BH4 (547.14) by Boslett, James, De Pascali, Francesco, Hemann, Craig, Zweier, Jay

“…CD38, a consumer of NAD+ and NADP+, is activated in I/R, leading to depletion of myocardial NADP(H) and consequently, lower eNOS function due to low levels of…”
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Luteolinidin, a naturally occurring flavonoid, decreases ischemia/reperfusion injury through inhibition of CD38 and preservation of NADPH and BH 4 (547.14) by Boslett, James, De Pascali, Francesco, Hemann, Craig, Zweier, Jay

“…Abstract only CD38, a consumer of NAD+ and NADP+, is activated in I/R, leading to depletion of myocardial NADP(H) and consequently, lower eNOS function due to…”
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