Search Results - "Bosinger, Steven E."

Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures by Vanderheiden, Abigail, Ralfs, Philipp, Chirkova, Tatiana, Upadhyay, Amit A, Zimmerman, Matthew G, Bedoya, Shamika, Aoued, Hadj, Tharp, Gregory M, Pellegrini, Kathryn L, Manfredi, Candela, Sorscher, Eric, Mainou, Bernardo, Lobby, Jenna L, Kohlmeier, Jacob E, Lowen, Anice C, Shi, Pei-Yong, Menachery, Vineet D, Anderson, Larry J, Grakoui, Arash, Bosinger, Steven E, Suthar, Mehul S

“…The newly emerged human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a pandemic of respiratory illness. Current…”
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The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination by Wimmers, Florian, Donato, Michele, Kuo, Alex, Ashuach, Tal, Gupta, Shakti, Li, Chunfeng, Dvorak, Mai, Foecke, Mariko Hinton, Chang, Sarah E., Hagan, Thomas, De Jong, Sanne E., Maecker, Holden T., van der Most, Robbert, Cheung, Peggie, Cortese, Mario, Bosinger, Steven E., Davis, Mark, Rouphael, Nadine, Subramaniam, Shankar, Yosef, Nir, Utz, Paul J., Khatri, Purvesh, Pulendran, Bali

“…Emerging evidence indicates a fundamental role for the epigenome in immunity. Here, we mapped the epigenomic and transcriptional landscape of immunity to…”
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Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques by Aid, Malika, Busman-Sahay, Kathleen, Vidal, Samuel J., Maliga, Zoltan, Bondoc, Stephen, Starke, Carly, Terry, Margaret, Jacobson, Connor A., Wrijil, Linda, Ducat, Sarah, Brook, Olga R., Miller, Andrew D., Porto, Maciel, Pellegrini, Kathryn L., Pino, Maria, Hoang, Timothy N., Chandrashekar, Abishek, Patel, Shivani, Stephenson, Kathryn, Bosinger, Steven E., Andersen, Hanne, Lewis, Mark G., Hecht, Jonathan L., Sorger, Peter K., Martinot, Amanda J., Estes, Jacob D., Barouch, Dan H.

“…The COVID-19 pandemic has led to extensive morbidity and mortality throughout the world. Clinical features that drive SARS-CoV-2 pathogenesis in humans include…”
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Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells by McBrien, Julia Bergild, Mavigner, Maud, Franchitti, Lavinia, Smith, S. Abigail, White, Erick, Tharp, Gregory K., Walum, Hasse, Busman-Sahay, Kathleen, Aguilera-Sandoval, Christian R., Thayer, William O., Spagnuolo, Rae Ann, Kovarova, Martina, Wahl, Angela, Cervasi, Barbara, Margolis, David M., Vanderford, Thomas H., Carnathan, Diane G., Paiardini, Mirko, Lifson, Jeffrey D., Lee, John H., Safrit, Jeffrey T., Bosinger, Steven E., Estes, Jacob D., Derdeyn, Cynthia A., Garcia, J. Victor, Kulpa, Deanna A., Chahroudi, Ann, Silvestri, Guido

“…Human immunodeficiency virus (HIV) persists indefinitely in individuals with HIV who receive antiretroviral therapy (ART) owing to a reservoir of latently…”
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Natural SIV Hosts: Showing AIDS the Door by Chahroudi, Ann, Bosinger, Steven E., Vanderford, Thomas H., Paiardini, Mirko, Silvestri, Guido

“…Many species of African nonhuman primates are naturally infected with simian immunodeficiency viruses (SIVs) in the wild and in captivity. In contrast to…”
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CD8+ Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy by Cartwright, Emily K., Spicer, Lori, Smith, S. Abigail, Lee, David, Fast, Randy, Paganini, Sara, Lawson, Benton O., Nega, Melon, Easley, Kirk, Schmitz, Joern E., Bosinger, Steven E., Paiardini, Mirko, Chahroudi, Ann, Vanderford, Thomas H., Estes, Jacob D., Lifson, Jeffrey D., Derdeyn, Cynthia A., Silvestri, Guido

“…Infection with HIV persists despite suppressive antiretroviral therapy (ART), and treatment interruption results in rapid viral rebound. Antibody-mediated CD8+…”
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A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs by Routhu, Nanda Kishore, Cheedarla, Narayanaiah, Gangadhara, Sailaja, Bollimpelli, Venkata Satish, Boddapati, Arun K., Shiferaw, Ayalnesh, Rahman, Sheikh Abdul, Sahoo, Anusmita, Edara, Venkata Viswanadh, Lai, Lilin, Floyd, Katharine, Wang, Shelly, Fischinger, Stephanie, Atyeo, Caroline, Shin, Sally A., Gumber, Sanjeev, Kirejczyk, Shannon, Cohen, Joyce, Jean, Sherrie M., Wood, Jennifer S., Connor-Stroud, Fawn, Stammen, Rachelle L., Upadhyay, Amit A., Pellegrini, Kathryn, Montefiori, David, Shi, Pei-Yong, Menachery, Vineet D., Alter, Galit, Vanderford, Thomas H., Bosinger, Steven E., Suthar, Mehul S., Amara, Rama Rao

“…A combination of vaccination approaches will likely be necessary to fully control the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic…”
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Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood by Nakaya, Helder I., Clutterbuck, Elizabeth, Kazmin, Dmitri, Wang, Lili, Cortese, Mario, Bosinger, Steven E., Patel, Nirav B., Zak, Daniel E., Aderem, Alan, Dong, Tao, Del Giudice, Giuseppe, Rappuoli, Rino, Cerundolo, Vincenzo, Pollard, Andrew J., Pulendran, Bali, Siegrist, Claire-Anne

“…The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly understood. Here we applied systems approaches to…”
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The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen by Havenar-Daughton, Colin, Sarkar, Anita, Kulp, Daniel W, Toy, Laura, Hu, Xiaozhen, Deresa, Isaiah, Kalyuzhniy, Oleksandr, Kaushik, Kirti, Upadhyay, Amit A, Menis, Sergey, Landais, Elise, Cao, Liwei, Diedrich, Jolene K, Kumar, Sonu, Schiffner, Torben, Reiss, Samantha M, Seumois, Grégory, Yates, John R, Paulson, James C, Bosinger, Steven E, Wilson, Ian A, Schief, William R, Crotty, Shane

“…Traditional vaccine development to prevent some of the worst current pandemic diseases has been unsuccessful so far. Germline-targeting immunogens have…”
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Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques by Bollimpelli, Venkata S., Reddy, Pradeep B. J, Gangadhara, Sailaja, Charles, Tysheena P., Burton, Samantha L., Tharp, Gregory K., Styles, Tiffany M., Labranche, Celia C., Smith, Justin C., Upadhyay, Amit A., Sahoo, Anusmita, Legere, Traci, Shiferaw, Ayalnesh, Velu, Vijayakumar, Yu, Tianwei, Tomai, Mark, Vasilakos, John, Kasturi, Sudhir P., Shaw, George M., Montefiori, David, Bosinger, Steven E., Kozlowski, Pamela A., Pulendran, Bali, Derdeyn, Cynthia A., Hunter, Eric, Amara, Rama R.

“…Route of immunization can markedly influence the quality of immune response. Here, we show that intradermal (ID) but not intramuscular (IM) modified vaccinia…”
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PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques by Dyavar Shetty, Ravi, Velu, Vijayakumar, Titanji, Kehmia, Bosinger, Steven E, Freeman, Gordon J, Silvestri, Guido, Amara, Rama Rao

“…Hyperimmune activation is a strong predictor of disease progression during pathogenic immunodeficiency virus infections and is mediated in part by sustained…”
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Innate, non-cytolytic CD8+ T cell-mediated suppression of HIV replication by MHC-independent inhibition of virus transcription by Zanoni, Michelle, Palesch, David, Pinacchio, Claudia, Statzu, Maura, Tharp, Gregory K, Paiardini, Mirko, Chahroudi, Ann, Bosinger, Steven E, Yoon, Jack, Cox, Bryan, Silvestri, Guido, Kulpa, Deanna A

“…MHC-I-restricted, virus-specific cytotoxic CD8+ T cells (CTLs) may control human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV)…”
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Natural killer-like B cells are a distinct but infrequent innate immune cell subset modulated by SIV infection of rhesus macaques by Manickam, Cordelia, Upadhyay, Amit A, Woolley, Griffin, Kroll, Kyle W, Terry, Karen, Broedlow, Courtney A, Klatt, Nichole R, Bosinger, Steven E, Reeves, R Keith

“…Natural killer-like B (NKB) cells are unique innate immune cells expressing both natural killer (NK) and B cell receptors. As first responders to infection,…”
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Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial by Balle, Christina, Konstantinus, Iyaloo N., Jaumdally, Shameem Z., Havyarimana, Enock, Lennard, Katie, Esra, Rachel, Barnabas, Shaun L., Happel, Anna-Ursula, Moodie, Zoe, Gill, Katherine, Pidwell, Tanya, Karaoz, Ulas, Brodie, Eoin, Maseko, Venessa, Gamieldien, Hoyam, Bosinger, Steven E., Myer, Landon, Bekker, Linda-Gail, Passmore, Jo-Ann S., Jaspan, Heather B.

“…Young women in sub-Saharan Africa are disproportionally affected by HIV infection and unintended pregnancies. However, hormonal contraceptive (HC) use may…”
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Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys by Bosinger, Steven E, Li, Qingsheng, Gordon, Shari N, Klatt, Nichole R, Duan, Lijie, Xu, Luoling, Francella, Nicholas, Sidahmed, Abubaker, Smith, Anthony J, Cramer, Elizabeth M, Zeng, Ming, Masopust, David, Carlis, John V, Ran, Longsi, Vanderford, Thomas H, Paiardini, Mirko, Isett, R Benjamin, Baldwin, Don A, Else, James G, Staprans, Silvija I, Silvestri, Guido, Haase, Ashley T, Kelvin, David J

“…Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic virus replication. Strikingly, it is characterized by low levels of immune…”
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CCR2 Signaling Restricts SARS-CoV-2 Infection by Vanderheiden, Abigail, Thomas, Jeronay, Soung, Allison L, Davis-Gardner, Meredith E, Floyd, Katharine, Jin, Fengzhi, Cowan, David A, Pellegrini, Kathryn, Shi, Pei-Yong, Grakoui, Arash, Klein, Robyn S, Bosinger, Steven E, Kohlmeier, Jacob E, Menachery, Vineet D, Suthar, Mehul S

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a historic pandemic of respiratory disease (coronavirus disease 2019 [COVID-19]), and…”
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TREM2+ and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques by Upadhyay, Amit A., Viox, Elise G., Hoang, Timothy N., Boddapati, Arun K., Pino, Maria, Lee, Michelle Y.-H., Corry, Jacqueline, Strongin, Zachary, Cowan, David A., Beagle, Elizabeth N., Horton, Tristan R., Hamilton, Sydney, Aoued, Hadj, Harper, Justin L., Edwards, Christopher T., Nguyen, Kevin, Pellegrini, Kathryn L., Tharp, Gregory K., Piantadosi, Anne, Levit, Rebecca D., Amara, Rama R., Barratt-Boyes, Simon M., Ribeiro, Susan P., Sekaly, Rafick P., Vanderford, Thomas H., Schinazi, Raymond F., Paiardini, Mirko, Bosinger, Steven E.

“…The immunopathological mechanisms driving the development of severe COVID-19 remain poorly defined. Here, we utilize a rhesus macaque model of acute SARS-CoV-2…”
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High throughput analysis of B cell dynamics and neutralizing antibody development during immunization with a novel clade C HIV-1 envelope by Mopuri, Rohini, Welbourn, Sarah, Charles, Tysheena, Ralli-Jain, Pooja, Rosales, David, Burton, Samantha, Aftab, Areeb, Karunakaran, Kirti, Pellegrini, Kathryn, Kilembe, William, Karita, Etienne, Gnanakaran, Sandrasegaram, Upadhyay, Amit A, Bosinger, Steven E, Derdeyn, Cynthia A

“…A protective HIV-1 vaccine has been hampered by a limited understanding of how B cells acquire neutralizing activity. Our previous vaccines expressing two…”
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Copper intrauterine device increases vaginal concentrations of inflammatory anaerobes and depletes lactobacilli compared to hormonal options in a randomized trial by Brown, Bryan P., Feng, Colin, Tanko, Ramla F., Jaumdally, Shameem Z., Bunjun, Rubina, Dabee, Smritee, Happel, Anna-Ursula, Gasper, Melanie, Nyangahu, Donald D., Onono, Maricianah, Nair, Gonasagrie, Palanee-Phillips, Thesla, Scoville, Caitlin W., Heller, Kate, Baeten, Jared M., Bosinger, Steven E., Burgener, Adam, Passmore, Jo-Ann S., Heffron, Renee, Jaspan, Heather B.

“…Effective contraceptives are a global health imperative for reproductive-aged women. However, there remains a lack of rigorous data regarding the effects of…”
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Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque by Rotger, Margalida, Dalmau, Judith, Rauch, Andri, McLaren, Paul, Bosinger, Steven E, Martinez, Raquel, Sandler, Netanya G, Roque, Annelys, Liebner, Julia, Battegay, Manuel, Bernasconi, Enos, Descombes, Patrick, Erkizia, Itziar, Fellay, Jacques, Hirschel, Bernard, Miró, Jose M, Palou, Eduard, Hoffmann, Matthias, Massanella, Marta, Blanco, Julià, Woods, Matthew, Günthard, Huldrych F, de Bakker, Paul, Douek, Daniel C, Silvestri, Guido, Martinez-Picado, Javier, Telenti, Amalio

“…High levels of HIV-1 replication during the chronic phase of infection usually correlate with rapid progression to severe immunodeficiency. However, a minority…”
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