Search Results - "Boshoff, I"

Fumarate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis by Watanabe, Shinya, Zimmermann, Michael, Goodwin, Michael B, Sauer, Uwe, Barry, 3rd, Clifton E, Boshoff, Helena I

“…Oxygen depletion of Mycobacterium tuberculosis engages the DosR regulon that coordinates an overall down-regulation of metabolism while up-regulating specific…”
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The spectrum of latent tuberculosis: rethinking the biology and intervention strategies by Young, Douglas, Barry, Clifton E, Boshoff, Helena I, Dartois, Véronique, Dick, Thomas, Ehrt, Sabine, Flynn, JoAnne, Schnappinger, Dirk, Wilkinson, Robert J

“…Key Points Latent tuberculosis is defined by the presence of an antigen-specific T cell response in the absence of clinical symptoms. It includes conditions…”
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SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis by Tahlan, Kapil, Wilson, Regina, Kastrinsky, David B, Arora, Kriti, Nair, Vinod, Fischer, Elizabeth, Barnes, S. Whitney, Walker, John R, Alland, David, Barry, Clifton E., III, Boshoff, Helena I

“…SQ109, a 1,2-diamine related to ethambutol, is currently in clinical trials for the treatment of tuberculosis, but its mode of action remains unclear. Here, we…”
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Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development by Beites, Tiago, O’Brien, Kathryn, Tiwari, Divya, Engelhart, Curtis A., Walters, Shaun, Andrews, Jenna, Yang, Hee-Jeong, Sutphen, Michelle L., Weiner, Danielle M., Dayao, Emmanuel K., Zimmerman, Matthew, Prideaux, Brendan, Desai, Prashant V., Masquelin, Thierry, Via, Laura E., Dartois, Véronique, Boshoff, Helena I., Barry, Clifton E., Ehrt, Sabine, Schnappinger, Dirk

“…The viability of Mycobacterium tuberculosis ( Mtb ) depends on energy generated by its respiratory chain. Cytochrome bc1-aa3 oxidase and type-2 NADH…”
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Tuberculosis Drug Discovery: A Decade of Hit Assessment for Defined Targets by Oh, Sangmi, Trifonov, Lena, Yadav, Veena D, Barry, 3rd, Clifton E, Boshoff, Helena I

“…More than two decades have elapsed since the publication of the first genome sequence of ( ) which, shortly thereafter, enabled methods to determine gene…”
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PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release by Singh, Ramandeep, Manjunatha, Ujjini, Boshoff, Helena I.M, Ha, Young Hwan, Niyomrattanakit, Pornwaratt, Ledwidge, Richard, Dowd, Cynthia S, Lee, Ill Young, Kim, Pilho, Zhang, Liang, Kang, Sunhee, Keller, Thomas H, Jiricek, Jan, Barry, Clifton E. 3rd

“…Bicyclic nitroimidazoles, including PA-824, are exciting candidates for the treatment of tuberculosis. These prodrugs require intracellular activation for…”
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Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery by Naran, Krupa, Moosa, Atica, Barry, 3rd, Clifton E, Boshoff, Helena I M, Mizrahi, Valerie, Warner, Digby F

“…The tuberculosis (TB) drug discovery pipeline is fueled by compounds identified in whole-cell screens against the causative agent, Mycobacterium tuberculosis…”
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Meropenem-Clavulanic Acid Shows Activity against Mycobacterium tuberculosis In Vivo by ENGLAND, Kathleen, BOSHOFF, Helena I. M, ARORA, Kriti, WEINER, Danielle, DAYAO, Emmanuel, SCHIMEL, Daniel, VIA, Laura E, BARRY, Clifton E

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The Three RelE Homologs of Mycobacterium tuberculosis Have Individual, Drug-Specific Effects on Bacterial Antibiotic Tolerance by SINGH, Ramandeep, BARRY, Clifton E, BOSHOFF, Helena I. M

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression by Woong Park, Sae, Klotzsche, Marcus, Wilson, Daniel J, Boshoff, Helena I, Eoh, Hyungjin, Manjunatha, Ujjini, Blumenthal, Antje, Rhee, Kyu, Barry, 3rd, Clifton E, Aldrich, Courtney C, Ehrt, Sabine, Schnappinger, Dirk

“…In the search for new drug targets, we evaluated the biotin synthetic pathway of Mycobacterium tuberculosis (Mtb) and constructed an Mtb mutant lacking the…”
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Mutations in gidB Confer Low-Level Streptomycin Resistance in Mycobacterium tuberculosis by WONG, Sharon Y, JONG SEOK LEE, HYUN KYUNG KWAK, VIA, Laura E, BOSHOFF, Helena I. M, BARRY, Clifton E

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches by Whitehouse, Andrew J, Thomas, Sherine E, Brown, Karen P, Fanourakis, Alexander, Chan, Daniel S.-H, Libardo, M. Daben J, Mendes, Vitor, Boshoff, Helena I. M, Floto, R. Andres, Abell, Chris, Blundell, Tom L, Coyne, Anthony G

“…Mycobacterium abscessus (Mab) is a rapidly growing species of multidrug-resistant nontuberculous mycobacteria that has emerged as a growing threat to…”
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Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis by Ioerger, Thomas R, O'Malley, Theresa, Liao, Reiling, Guinn, Kristine M, Hickey, Mark J, Mohaideen, Nilofar, Murphy, Kenan C, Boshoff, Helena I M, Mizrahi, Valerie, Rubin, Eric J, Sassetti, Christopher M, Barry, 3rd, Clifton E, Sherman, David R, Parish, Tanya, Sacchettini, James C

“…Identification of new drug targets is vital for the advancement of drug discovery against Mycobacterium tuberculosis, especially given the increase of…”
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Uncovering the Serine Hydrolytic Landscape of Mycobacterium tuberculosis by Boshoff, Helena I

“…In this issue of Cell Chemical Biology, Ortega et al. (2016) present a study utilizing a click-chemistry-enabled fluorophosphonate for activity-based…”
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Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis by Arnvig, Kristine B, Comas, Iñaki, Thomson, Nicholas R, Houghton, Joanna, Boshoff, Helena I, Croucher, Nicholas J, Rose, Graham, Perkins, Timothy T, Parkhill, Julian, Dougan, Gordon, Young, Douglas B

“…RNA sequencing provides a new perspective on the genome of Mycobacterium tuberculosis by revealing an extensive presence of non-coding RNA, including long 5'…”
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Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis by Kumar, Pradeep, Arora, Kriti, Lloyd, John R., Lee, Ill Y., Nair, Vinod, Fischer, Elizabeth, Boshoff, Helena I. M., Barry III, Clifton E.

“…Summary Carbapenems such as meropenem are being investigated for their potential therapeutic utility against highly drug‐resistant tuberculosis. These…”
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Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis by Barry, Clifton E, Davis, Benjamin G, Backus, Keriann M, Boshoff, Helena I, Barry, Conor S, Boutureira, Omar, Patel, Mitul K, D'Hooge, François, Lee, Seung Seo, Via, Laura E, Tahlan, Kapil

“…The use of synthetic analogs to explore substrate promiscuity during trehalose incorporation into the mycobacterial cell wall yields a fluorescent probe that…”
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Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure–Activity As Potential Antituberculosis Agents by Chacko, Shibin, Boshoff, Helena I. M, Singh, Vinayak, Ferraris, Davide M, Gollapalli, Deviprasad R, Zhang, Minjia, Lawson, Ann P, Pepi, Michael J, Joachimiak, Andrzej, Rizzi, Menico, Mizrahi, Valerie, Cuny, Gregory D, Hedstrom, Lizbeth

“…New drugs and molecular targets are urgently needed to address the emergence and spread of drug-resistant tuberculosis. Mycobacterium tuberculosis (Mtb)…”
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Susceptibility of Mycobacterium tuberculosis Cytochrome bd Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome c by Moosa, Atica, Lamprecht, Dirk A, Arora, Kriti, Barry, 3rd, Clifton E, Boshoff, Helena I M, Ioerger, Thomas R, Steyn, Adrie J C, Mizrahi, Valerie, Warner, Digby F

“…We deleted subunits I ( ) and II ( ) of the cytochrome menaquinol oxidase. The resulting Δ and Δ mutants were hypersusceptible to compounds targeting the…”
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Editorial: Drug-resistant Mycobacterium tuberculosis by Boshoff, Helena I M, Warner, Digby F, Gold, Ben

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