An Appraisal of Current Pharmacological Perspectives of Sesamol: A Review

Sesame (Sesamum indicum L.) seeds have been authenticated for its medicinal value in both Chinese and Indian systems of medicine. Its numerous potential nutritional benefits are attributed to its main bioactive constituents, sesamol. As a result of those studies, several molecular mechanisms are eme...

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Bibliographic Details
Published in:	Mini reviews in medicinal chemistry Vol. 20; no. 11; p. 988
Main Authors:	Bosebabu, Bellamkonda, Cheruku, Sri Pragnya, Chamallamudi, Mallikarjuna Rao, Nampoothiri, Madhavan, Shenoy, Rekha R, Nandakumar, Krishnadas, Parihar, Vipan K, Kumar, Nitesh
Format:	Journal Article
Language:	English
Published:	Netherlands 01-01-2020
Subjects:	Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Benzodioxoles - chemistry Benzodioxoles - pharmacology Cytokines - antagonists & inhibitors Cytokines - biosynthesis Humans Inflammation - drug therapy Inflammation - metabolism Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Phenols - chemistry Phenols - pharmacology Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein Kinases - metabolism Sesamum - chemistry pharmacological activities antioxidant in vitro anti-inflammatory Sesamol cancer cells in vivo pleiotropic sesame seed anti-microbial
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Summary:	Sesame (Sesamum indicum L.) seeds have been authenticated for its medicinal value in both Chinese and Indian systems of medicine. Its numerous potential nutritional benefits are attributed to its main bioactive constituents, sesamol. As a result of those studies, several molecular mechanisms are emerging describing the pleiotropic biological effects of sesamol. This review summarized the most interesting in vitro and in vivo studies on the biological effects of sesamol. The present work summarises data available from Pubmed and Scopus database. Several molecular mechanisms have been elucidated describing the pleiotropic biological effects of sesamol. Its major therapeutic effects have been elicited in managing oxidative and inflammatory conditions, metabolic syndrome and mood disorders. Further, compelling evidence reflected the ability of sesamol in inhibiting proliferation of the inflammatory cell, prevention of invasion and angiogenesis via affecting multiple molecular targets and downstream mechanisms. Sesamol is a safe, non-toxic chemical that mediates anti-inflammatory effects by down-regulating the transcription of inflammatory markers such as cytokines, redox status, protein kinases, and enzymes that promote inflammation. In addition, sesamol also induces apoptosis in cancer cells via mitochondrial and receptor-mediated pathways, as well as activation of caspase cascades. In the present review, several pharmacological effects of sesamol are summarised namely, antioxidant, anti-cancer, neuroprotective, cardioprotective, anti-inflammatory, hypolipidemic, radioprotective, anti-aging, anti-ulcer, anti-dementia, anti-depressant, antiplatelet, anticonvulsant, anti-anxiolytic, wound healing, cosmetic (skin whitening), anti-microbial, matrix metalloproteinase (MMPs) inhibition, hepatoprotective activity and other biological effects. Here we have summarized the proposed mechanism behind these pharmacological effects.
ISSN:	1875-5607
DOI:	10.2174/1389557520666200313120419