Search Results - "Bose, Suchira"
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Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates
Published in The Journal of biological chemistry (09-01-2015)“…Intracellular Tau inclusions are a pathological hallmark of several neurodegenerative diseases, collectively known as the tauopathies. They include Alzheimer…”
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2
Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network
Published in The Journal of biological chemistry (10-05-2019)“…Tauopathies are a diverse class of neurodegenerative diseases characterized by the formation of insoluble tau aggregates and the loss of cellular function and…”
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3
A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer’s disease
Published in Scientific reports (17-02-2022)“…Cellular models recapitulating features of tauopathies are useful tools to investigate the causes and consequences of tau aggregation and the identification of…”
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Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau
Published in The Journal of neuroscience (20-01-2016)“…The interneuronal propagation of aggregated tau is believed to play an important role in the pathogenesis of human tauopathies. It requires the uptake of…”
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Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model
Published in Molecular neurodegeneration (17-12-2018)“…Activation of microglia, the resident immune cells of the central nervous system, is a prominent pathological hallmark of Alzheimer's disease (AD). However,…”
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The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer's Disease Pathology
Published in Cells (Basel, Switzerland) (01-02-2024)“…The levels of p-tau217 and p-tau231 in cerebrospinal fluid (CSF) are associated with early amyloid beta (Aß) changes in the brain, while the CSF levels of…”
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Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b
Published in Alzheimer's research & therapy (14-03-2023)“…A key histopathological hallmark of Alzheimer's disease (AD) is the presence of neurofibrillary tangles of aggregated microtubule-associated protein tau in…”
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Phosphorylation of 20S proteasome alpha subunit C8 (alpha7) stabilizes the 26S proteasome and plays a role in the regulation of proteasome complexes by gamma-interferon
Published in Biochemical journal (15-02-2004)“…In animal cells there are several regulatory complexes which interact with 20S proteasomes and give rise to functionally distinct proteasome complexes…”
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9
Chaperone Function of Hsp90-Associated Proteins
Published in Science (American Association for the Advancement of Science) (06-12-1996)“…The Hsp90 heat shock protein of eukaryotic cells regulates the activity of proteins involved in signal transduction pathways and may direct intracellular…”
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Assessment of the ATP Binding Properties of Hsp90
Published in The Journal of biological chemistry (26-04-1996)“…Hsp90, one of the most prominent proteins in eucaryotic cells under physiological and stress conditions, chaperones protein folding reactions in an…”
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11
Synaptic Release of Pathological Tau Is Calcium- and SNAP25-Dependent, and Blocked by BoNT-A Activity
Published in Toxicon (Oxford) (01-01-2024)Get full text
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A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity
Published in Acta neuropathologica (01-05-2014)“…Intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of Alzheimer’s disease, progressive supranuclear palsy, Pick’s disease…”
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13
Mechanism of tau R3 aggregation and inhibition revealed by NMR-based chemical kinetics
Published in Biophysical journal (11-02-2022)Get full text
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14
Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures
Published in The Journal of biological chemistry (11-09-2020)“…Tau aggregation and hyperphosphorylation is a key neuropathological hallmark of Alzheimer's disease (AD), and the temporospatial spread of Tau observed during…”
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15
Metabotropic Glutamate Receptors Modulate Exocytotic Tau Release and Propagation
Published in The Journal of pharmacology and experimental therapeutics (01-11-2022)“…Using synaptosomes purified from the brains of two transgenic mouse models overexpressing mutated human tau (TgP301S and Tg4510) and brains of patients with…”
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An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease
Published in The Journal of biological chemistry (09-08-2013)“…Neurofibrillary tangles, one of the hallmarks of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylated tau. The…”
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Identifying early markers of synaptic dysfunction in a mouse model of tauopathy: Molecular and cell biology/synaptic disruption
Published in Alzheimer's & dementia (01-12-2020)“…Abstract Background Synaptic degeneration is currently the best correlate of cognitive decline in Alzheimer’s Disease. Tau pathology, one of the hallmarks of…”
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18
Identifying early markers of synaptic dysfunction in a mouse model of tauopathy
Published in Alzheimer's & dementia (01-12-2020)“…Background Synaptic degeneration is currently the best correlate of cognitive decline in Alzheimer’s Disease. Tau pathology, one of the hallmarks of the…”
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Purification and characterization of prokaryotic and eukaryotic Hsp90
Published in Methods in enzymology (1998)Get more information
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Purification of Hsp90 partner proteins Hop/p60, p23, and FKBP52
Published in Methods in enzymology (1998)Get more information
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