Search Results - "Bose, Suchira"

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    Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates by Falcon, Benjamin, Cavallini, Annalisa, Angers, Rachel, Glover, Sarah, Murray, Tracey K., Barnham, Luanda, Jackson, Samuel, O'Neill, Michael J., Isaacs, Adrian M., Hutton, Michael L., Szekeres, Philip G., Goedert, Michel, Bose, Suchira

    Published in The Journal of biological chemistry (09-01-2015)
    “…Intracellular Tau inclusions are a pathological hallmark of several neurodegenerative diseases, collectively known as the tauopathies. They include Alzheimer…”
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    Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network by Yu, Anan, Fox, Susan G., Cavallini, Annalisa, Kerridge, Caroline, O’Neill, Michael J., Wolak, Joanna, Bose, Suchira, Morimoto, Richard I.

    Published in The Journal of biological chemistry (10-05-2019)
    “…Tauopathies are a diverse class of neurodegenerative diseases characterized by the formation of insoluble tau aggregates and the loss of cellular function and…”
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    A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer’s disease by Ficulle, Elena, Kananathan, Sarubini, Airey, David, Gharbi, Severine I., Humphryes-Kirilov, Neil, Scherschel, James, Dunbar, Charlotte, Eastwood, Brian J., Laing, Emma, Collier, David A., Bose, Suchira

    Published in Scientific reports (17-02-2022)
    “…Cellular models recapitulating features of tauopathies are useful tools to investigate the causes and consequences of tau aggregation and the identification of…”
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    The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer's Disease Pathology by Wennström, Malin, Schultz, Nina, Gallardo, Paula Mille, The Netherlands Brain Bank, Serrano, Geidy E, Beach, Thomas G, Bose, Suchira, Hansson, Oskar

    Published in Cells (Basel, Switzerland) (01-02-2024)
    “…The levels of p-tau217 and p-tau231 in cerebrospinal fluid (CSF) are associated with early amyloid beta (Aß) changes in the brain, while the CSF levels of…”
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    Phosphorylation of 20S proteasome alpha subunit C8 (alpha7) stabilizes the 26S proteasome and plays a role in the regulation of proteasome complexes by gamma-interferon by Bose, Suchira, Stratford, Fiona L L, Broadfoot, Kerry I, Mason, Grant G F, Rivett, A Jennifer

    Published in Biochemical journal (15-02-2004)
    “…In animal cells there are several regulatory complexes which interact with 20S proteasomes and give rise to functionally distinct proteasome complexes…”
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    Chaperone Function of Hsp90-Associated Proteins by Bose, Suchira, Weikl, Tina, Bugl, Hans, Buchner, Johannes

    “…The Hsp90 heat shock protein of eukaryotic cells regulates the activity of proteins involved in signal transduction pathways and may direct intracellular…”
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    Assessment of the ATP Binding Properties of Hsp90 by Jakob, U, Scheibel, T, Bose, S, Reinstein, J, Buchner, J

    Published in The Journal of biological chemistry (26-04-1996)
    “…Hsp90, one of the most prominent proteins in eucaryotic cells under physiological and stress conditions, chaperones protein folding reactions in an…”
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    Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures by Katsikoudi, Antigoni, Ficulle, Elena, Cavallini, Annalisa, Sharman, Gary, Guyot, Amelie, Zagnoni, Michele, Eastwood, Brian J., Hutton, Michael, Bose, Suchira

    Published in The Journal of biological chemistry (11-09-2020)
    “…Tau aggregation and hyperphosphorylation is a key neuropathological hallmark of Alzheimer's disease (AD), and the temporospatial spread of Tau observed during…”
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    Identifying early markers of synaptic dysfunction in a mouse model of tauopathy: Molecular and cell biology/synaptic disruption by Meftah, Soraya, Witton, Jonathan, Cavallini, Annalisa, Murray, Tracey K., Jankowski, Lukasz, Bose, Suchira, Ashby, Michael, Brown, Jonathan T.

    Published in Alzheimer's & dementia (01-12-2020)
    “…Abstract Background Synaptic degeneration is currently the best correlate of cognitive decline in Alzheimer’s Disease. Tau pathology, one of the hallmarks of…”
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    Identifying early markers of synaptic dysfunction in a mouse model of tauopathy by Meftah, Soraya, Witton, Jonathan, Cavallini, Annalisa, Murray, Tracey K., Jankowski, Lukasz, Bose, Suchira, Ashby, Michael, Brown, Jonathan T.

    Published in Alzheimer's & dementia (01-12-2020)
    “…Background Synaptic degeneration is currently the best correlate of cognitive decline in Alzheimer’s Disease. Tau pathology, one of the hallmarks of the…”
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    Journal Article
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