Diffuse Idiopathic Skeletal Hyperostosis (DISH) in Type 2 Diabetes: A New Imaging Possibility and a New Biomarker

Diffuse Idiopathic Skeletal Hyperostosis (DISH) in Type 2 Diabetes: A New Imaging Possibility and a New Biomarker

We performed a cross-sectional study to investigate the prevalence of Diffuse Idiopathic Skeletal Hyperostosis (DISH) through Dual-Energy X-ray absorptiometry (DXA) Vertebral Fracture Assessment (VFA) in a group of post-menopausal women with Type 2 Diabetes Mellitus (T2DM). We also explored several...

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Published in:Calcified tissue international Vol. 108; no. 2; pp. 231 - 239
Main Authors: Fassio, Angelo, Adami, Giovanni, Idolazzi, Luca, Giollo, Alessandro, Viapiana, Ombretta, Bosco, Emma, Negrelli, Riccardo, Sani, Elena, Sandri, Damiano, Mantovani, Alessandro, Targher, Giovanni, Rossini, Maurizio, Gatti, Davide
Format: Journal Article
Language:English
Published: New York Springer US 01-02-2021
Springer Nature B.V
Subjects:
Absorptiometry, Photon
Adaptor Proteins, Signal Transducing - blood
Biochemistry
Biomarkers
Biomarkers - blood
Biomedical and Life Sciences
Bone Density
Bone Remodeling
Bone turnover
Cell Biology
Cross-Sectional Studies
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Dual energy X-ray absorptiometry
Endocrinology
Female
Humans
Hyperostosis, Diffuse Idiopathic Skeletal - diagnostic imaging
Life Sciences
Menopause
Original Research
Orthopedics
Osteoporosis
Post-menopause
Postmenopause
Radiography
Serum levels
SOST protein
Statistical analysis
Vertebrae
Wnt protein
Wnt Signaling Pathway
Osteoporosis
Diffuse idiopathic skeletal hyperostosis
Wnt pathway
Dkk-1
Sclerostin
Type 2 diabetes mellitus
Densitometry
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Summary:We performed a cross-sectional study to investigate the prevalence of Diffuse Idiopathic Skeletal Hyperostosis (DISH) through Dual-Energy X-ray absorptiometry (DXA) Vertebral Fracture Assessment (VFA) in a group of post-menopausal women with Type 2 Diabetes Mellitus (T2DM). We also explored several biomarkers of bone turnover metabolism, including Wnt pathway modulators. DXA-VFA was performed to detect the presence of DISH. Serum samples were collected from all patients at the time of study recruitment. 16 different serum biomarkers were tested between the two subgroups. Given the exploratory nature of the study, we did not adjust for multiplicity. At VFA analysis, among 96 individuals enrolled in the study 20 (20.8%) showed features of DISH. No statistically significant difference was found for BMD values, between the DISH and NO-DISH subgroups. Concerning blood biomarkers, DISH patients showed a significant difference only in the sclerostin serum levels (32 vs 35.5 pmol/L, for the DISH and NO-DISH subgroup, respectively; p  = 0.010). After adjustment for confounding factors, sclerostin serum levels remained significantly lower in DISH group ( p  = 0.002). We demonstrated a non-negligible prevalence of DISH in a population of post-menopausal women affected by T2DM and suggested low serum sclerostin as a possible key feature associated with DISH presence. In addition, we propose DXA-VFA analysis, whose radiation dose is considerably lower than conventional radiography, as a viable diagnostic and prognostic mean to obtain data not only on bone health, but also for the screening for DISH in subjects at risk.
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ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-020-00768-2