Search Results - "Boschero, C"

Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus by De Souza, Cláudio T, Araujo, Eliana P, Bordin, Silvana, Ashimine, Rika, Zollner, Ricardo L, Boschero, Antonio C, Saad, Mário J. A, Velloso, Lício A

“…Obesity has reached epidemic proportions in several regions of the world. General changes in lifestyle, including consumption of fat-rich food, are among the…”
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The bile acid TUDCA reduces age-related hyperinsulinemia in mice by Zangerolamo, Lucas, Carvalho, Marina, Barssotti, Leticia, Soares, Gabriela M., Marmentini, Carine, Boschero, Antonio C., Barbosa, Helena Cristina L.

“…Aging is associated with glucose metabolism disturbances, such as insulin resistance and hyperinsulinemia, which contribute to the increased prevalence of type…”
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Acute Exercise Improves Insulin Clearance and Increases the Expression of Insulin-Degrading Enzyme in the Liver and Skeletal Muscle of Swiss Mice by Kurauti, Mirian A, Freitas-Dias, Ricardo, Ferreira, Sandra M, Vettorazzi, Jean F, Nardelli, Tarlliza R, Araujo, Hygor N, Santos, Gustavo J, Carneiro, Everardo M, Boschero, Antonio C, Rezende, Luiz F, Costa-Júnior, José M

“…The effects of exercise on insulin clearance and IDE expression are not yet fully elucidated. Here, we have explored the effect of acute exercise on insulin…”
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Interleukin-6 increases the expression and activity of insulin-degrading enzyme by Kurauti, Mirian A., Costa-Júnior, José M., Ferreira, Sandra M., Santos, Gustavo J., Sponton, Carlos H. G., Carneiro, Everardo M., Telles, Guilherme D., Chacon-Mikahil, Mara P. T., Cavaglieri, Cláudia R., Rezende, Luiz F., Boschero, Antonio C.

“…Impairment of the insulin-degrading enzyme (IDE) is associated with obesity and type 2 diabetes mellitus (T2DM). Here, we used 4-mo-old male C57BL/6…”
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Aging Reduces Insulin Clearance in Mice by Marmentini, Carine, Soares, Gabriela M, Bronczek, Gabriela A, Piovan, Silvano, Mareze-Costa, Cecília E, Carneiro, Everardo M, Boschero, Antonio C, Kurauti, Mirian A

“…Hyperinsulinemia is frequently associated with aging and may cause insulin resistance in elderly. Since insulin secretion and clearance decline with age,…”
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Energy homeostasis deregulation is attenuated by TUDCA treatment in streptozotocin-induced Alzheimer’s disease mice model by Zangerolamo, Lucas, Solon, Carina, Soares, Gabriela M., Engel, Daiane F., Velloso, Licio A., Boschero, Antonio C., Carneiro, Everardo M., Barbosa, Helena Cristina L.

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. While cognitive deficits remain the major…”
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ARHGAP21 as a master regulator of multiple cellular processes by Rosa, Lucas R. O., Soares, Gabriela M., Silveira, Leonardo R., Boschero, Antonio C., Barbosa‐Sampaio, Helena C. L.

“…The cellular cytoskeleton is involved with multiple biological processes and is tightly regulated by multiple proteins and effectors. Among these, the…”
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Paternal Exercise Improves the Metabolic Health of Offspring via Epigenetic Modulation of the Germline by Costa-Júnior, José Maria, Ferreira, Sandra Mara, Kurauti, Mirian Ayumi, Bernstein, Diana L, Ruano, Elena G, Kameswaran, Vasumathi, Schug, Jonathan, Freitas-Dias, Ricardo, Zoppi, Claudio C, Boschero, Antonio C, Oliveira, Camila A M de, Santos, Gustavo J, Carneiro, Everardo M, Kaestner, Klaus H

“…Epigenetic regulation is considered the main molecular mechanism underlying the developmental origin of health and disease's (DOHAD) hypothesis. Previous…”
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Acute exercise restores insulin clearance in diet-induced obese mice by Kurauti, Mirian A, Costa-Júnior, José M, Ferreira, Sandra M, dos Santos, Gustavo J, Protzek, André O P, Nardelli, Tarlliza R, de Rezende, Luiz F, Boschero, Antonio C

“…The aim of this study was to investigate the insulin clearance in diet-induced obese (DIO) mice submitted to acute endurance exercise (3h of treadmill exercise…”
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Enhanced glucose-induced intracellular signaling promotes insulin hypersecretion: Pancreatic beta-cell functional adaptations in a model of genetic obesity and prediabetes by Irles, Esperanza, Ñeco, Patricia, Lluesma, Mónica, Villar-Pazos, Sabrina, Santos-Silva, Junia Carolina, Vettorazzi, Jean F., Alonso-Magdalena, Paloma, Carneiro, Everardo M., Boschero, Antonio C., Nadal, Ángel, Quesada, Ivan

“…•Pancreatic β-cells from obese ob/ob mice display numerous functional adaptations.•ob/ob β-Cells exhibit enhanced mitochondrial activity in response to…”
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Effects of growth hormone-releasing hormone agonistic analog MR-409 on insulin-secreting cells under cyclopiazonic acid-induced endoplasmic reticulum stress by Rodrigues-dos-Santos, Karina, Soares, Gabriela M., Guimarães, Dimitrius S.P.S.F., Araújo, Thiago R., Vettorazzi, Jean F., Zangerolamo, Lucas, Marconato-Júnior, Emilio, Cai, Renzhi, Sha, Wei, Schally, Andrew V., Boschero, Antônio C., Barbosa, Helena C.L.

“…The endoplasmic reticulum (ER) stress is one of the mechanisms related to decreased insulin secretion and beta cell death, contributing to the progress of type…”
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Role of microRNAs on the Regulation of Mitochondrial Biogenesis and Insulin Signaling in Skeletal Muscle by Lima, Tanes I., Araujo, Hygor N., Menezes, Eveline S., Sponton, Carlos H., Araújo, Michel B., Bomfim, Lucas H.M., Queiroz, André L., Passos, Madla A., e Sousa, Thais Amaral, Hirabara, Sandro M., Martins, Amanda R., Sampaio, Helena C.L.B., Rodrigues, Alice, Curi, Rui, Carneiro, Everardo M., Boschero, Antônio C., Silveira, Leonardo R.

“…Mitochondria play a critical role in several cellular processes and cellular homeostasis. Mitochondrion dysfunction has been correlated with numerous metabolic…”
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Taurine supplementation improves liver glucose control in normal protein and malnourished mice fed a high-fat diet by Batista, Thiago M., Ribeiro, Rosane A., da Silva, Priscilla M. R., Camargo, Rafael L., Lollo, Pablo C. B., Boschero, Antonio C., Carneiro, Everardo M.

“…Scope Poor nutrition during the perinatal period is associated with an increased risk for metabolic syndrome in adulthood. Taurine (TAU) regulates β‐cell…”
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Pancreatic alpha-cell dysfunction contributes to the disruption of glucose homeostasis and compensatory insulin hypersecretion in glucocorticoid-treated rats by Rafacho, Alex, Gonçalves-Neto, Luiz M, Santos-Silva, Junia C, Alonso-Magdalena, Paloma, Merino, Beatriz, Taboga, Sebastião R, Carneiro, Everardo M, Boschero, Antonio C, Nadal, Angel, Quesada, Ivan

“…Glucocorticoid (GC)-based therapies can cause insulin resistance (IR), glucose intolerance, hyperglycemia and, occasionally, overt diabetes. Understanding the…”
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Cafeteria diet inhibits insulin clearance by reduced insulin-degrading enzyme expression and mRNA splicing by Brandimarti, P, Costa-Júnior, J M, Ferreira, S M, Protzek, A O, Santos, G J, Carneiro, E M, Boschero, A C, Rezende, L F

“…Insulin clearance plays a major role in glucose homeostasis and insulin sensitivity in physiological and/or pathological conditions, such as obesity-induced…”
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Hepatocyte Growth Factor Plays a Key Role in Insulin Resistance-Associated Compensatory Mechanisms by Araújo, Tiago G, Oliveira, Alexandre G, Carvalho, Bruno M, Guadagnini, Dioze, Protzek, André O.P, Carvalheira, Jose B.C, Boschero, Antonio C, Saad, Mario J.A

“…Insulin resistance is present in obesity and in type 2 diabetes and is associated with islet cell hyperplasia and hyperinsulinemia, but the driving forces…”
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Mice born to females with oocyte-specific deletion of mitofusin 2 have increased weight gain and impaired glucose homeostasis by Garcia, Bruna M, Machado, Thiago S, Carvalho, Karen F, Nolasco, Patrícia, Nociti, Ricardo P, del Collado, Maite, Capo Bianco, Maria J D, Grejo, Mateus P, Augusto Neto, José Djaci, Sugiyama, Fabrícia H C, Tostes, Katiane, Pandey, Anand K, Gonçalves, Luciana M, Perecin, Felipe, Meirelles, Flávio V, Ferraz, José Bento S, Vanzela, Emerielle C, Boschero, Antônio C, Guimarães, Francisco E G, Abdulkader, Fernando, Laurindo, Francisco R M, Kowaltowski, Alicia J, Chiaratti, Marcos R

“…Abstract Offspring born to obese and diabetic mothers are prone to metabolic diseases, a phenotype that has been linked to mitochondrial dysfunction and…”
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ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin Secretion Process by Ferreira, Sandra M, Costa-Júnior, José M, Kurauti, Mirian A, Leite, Nayara C, Ortis, Fernanda, Rezende, Luiz F, Barbosa, Helena C, Boschero, Antonio C, Santos, Gustavo J

“…ARHGAP21 is a RhoGAP protein implicated in the modulation of insulin secretion and energy metabolism. ARHGAP21 transient-inhibition increase glucose-stimulated…”
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Morphofunctional alterations in endocrine pancreas of short- and long-term dexamethasone-treated rats by Rafacho, A, Abrantes, J L F, Ribeiro, D L, Paula, F M, Pinto, M E, Boschero, A C, Bosqueiro, J R

“…Long-term dexamethasone therapy may induce peripheral insulin resistance (IR), which in turn elicits increased beta-cell function and proliferation. However,…”
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Taurine supplementation: involvement of cholinergic/phospholipase C and protein kinase A pathways in potentiation of insulin secretion and Ca2+ handling in mouse pancreatic islets by Ribeiro, Rosane A., Vanzela, Emerielle C., Oliveira, Camila A. M., Bonfleur, Maria L., Boschero, Antonio C., Carneiro, Everardo M.

“…Taurine (TAU) supplementation increases insulin secretion in response to high glucose concentrations in rodent islets. This effect is probably due to an…”
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