Search Results - "Bosch Morató, Mònica"

Epigallocatechin-3-gallate improves cardiac hypertrophy and short-term memory deficits in a Williams-Beuren syndrome mouse model by Ortiz-Romero, Paula, Borralleras, Cristina, Bosch-Morató, Mònica, Guivernau, Biuse, Albericio, Guillermo, Muñoz, Francisco J, Pérez-Jurado, Luis A, Campuzano, Victoria

“…Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder caused by a heterozygous deletion of 26-28 genes at chromosome band 7q11.23. The complete…”
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Amyloid-β Peptide Nitrotyrosination Stabilizes Oligomers and Enhances NMDAR-Mediated Toxicity by Guivernau, Biuse, Bonet, Jaume, Valls-Comamala, Victòria, Bosch-Morató, Mònica, Godoy, Juan A, Inestrosa, Nibaldo C, Perálvarez-Marín, Alex, Fernández-Busquets, Xavier, Andreu, David, Oliva, Baldomero, Muñoz, Francisco J

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the pathological aggregation of the amyloid-β peptide (Aβ). Monomeric soluble Aβ can…”
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A Genome-Wide Functional Screen Identifies Enhancer and Protective Genes for Amyloid Beta-Peptide Toxicity by Picón-Pagès, Pol, Bosch-Morató, Mònica, Subirana, Laia, Rubio-Moscardó, Francisca, Guivernau, Biuse, Fanlo-Ucar, Hugo, Zeylan, Melisa Ece, Senyuz, Simge, Herrera-Fernández, Víctor, Vicente, Rubén, Fernández-Fernández, José M, García-Ojalvo, Jordi, Gursoy, Attila, Keskin, Ozlem, Oliva, Baldomero, Posas, Francesc, de Nadal, Eulàlia, Muñoz, Francisco J

“…Alzheimer's disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led to treatments to prevent…”
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Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis by Ill-Raga, Gerard, Tajes, Marta, Busquets-García, Arnau, Ramos-Fernández, Eva, Vargas, Lina M, Bosch-Morató, Mònica, Guivernau, Biuse, Valls-Comamala, Victòria, Eraso-Pichot, Abel, Guix, Francesc X, Fandos, César, Rosen, Mark D, Rabinowitz, Michael H, Maldonado, Rafael, Alvarez, Alejandra R, Ozaita, Andrés, Muñoz, Francisco J

“…Hippocampus is the brain center for memory formation, a process that requires synaptogenesis. However, hippocampus is dramatically compromised in Alzheimer's…”
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Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death by ILL-Raga, Gerard, Palomer, Ernest, Ramos-Fernández, Eva, Guix, Francesc X., Bosch-Morató, Mònica, Guivernau, Biuse, Tajes, Marta, Valls-Comamala, Victòria, Jiménez-Conde, Jordi, Ois, Angel, Pérez-Asensio, Fernando, Reyes-Navarro, Mario, Caballo, Carolina, Gil-Gómez, Gabriel, Lopez-Vilchez, Irene, Galan, Ana M., Alameda, Francesc, Escolar, Gines, Opazo, Carlos, Planas, Anna M., Roquer, Jaume, Valverde, Miguel A., Muñoz, Francisco J.

“…Ischemic stroke is an acute vascular event that compromises neuronal viability, and identification of the pathophysiological mechanisms is critical for its…”
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Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: implications in cytotoxicity and amyloid-β peptide aggregation by Ramos-Fernández, Eva, Tajes, Marta, Palomer, Ernest, Ill-Raga, Gerard, Bosch-Morató, Mònica, Guivernau, Biuse, Román-Dégano, Irene, Eraso-Pichot, Abel, Alcolea, Daniel, Fortea, Juan, Nuñez, Laura, Paez, Antonio, Alameda, Francesc, Fernández-Busquets, Xavier, Lleó, Alberto, Elosúa, Roberto, Boada, Mercé, Valverde, Miguel A, Muñoz, Francisco J

“…Glycation and nitrotyrosination are pathological posttranslational modifications that make proteins prone to losing their physiological properties. Since both…”
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Vitamin E dietary supplementation improves neurological symptoms and decreases c-Abl/p73 activation in Niemann-Pick C mice by Marín, Tamara, Contreras, Pablo, Castro, Juan Francisco, Chamorro, David, Balboa, Elisa, Bosch-Morató, Mònica, Muñoz, Francisco J, Alvarez, Alejandra R, Zanlungo, Silvana

“…Niemann-Pick C (NPC) disease is a fatal neurodegenerative disorder characterized by the accumulation of free cholesterol in lysosomes. We have previously…”
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Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease by Tajes, Marta, Eraso-Pichot, Abel, Rubio-Moscardó, Fanny, Guivernau, Biuse, Ramos-Fernández, Eva, Bosch-Morató, Mònica, Guix, Francesc Xavier, Clarimón, Jordi, Miscione, Gian Pietro, Boada, Mercé, Gil-Gómez, Gabriel, Suzuki, Toshiharu, Molina, Henrik, Villà-Freixa, Jordi, Vicente, Rubén, Muñoz, Francisco J

“…Amyloid-β peptide (Aβ) aggregates induce nitro-oxidative stress, contributing to the characteristic neurodegeneration found in Alzheimer's disease (AD). One of…”
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Nitro-Oxidative Stress after Neuronal Ischemia Induces Protein Nitrotyrosination and Cell Death by Bosch-Morató, Mònica, Guix, Francesc X., Ramos-Fernández, Eva, Palomer, Ernest, ILL-Raga, Gerard, Tajes, Marta, Guivernau, Biuse, Jiménez-Conde, Jordi, Ois, Angel, Pérez-Asensio, Fernando, Reyes-Navarro, Mario, Caballo, Carolina, Galán, Ana M., Alameda, Francesc, Escolar, Ginés, Opazo, Carlos, Planas, Anna, Roquer, Jaume, Valverde, Miguel A., Muñoz, Francisco J.

“…Ischemic stroke is an acute vascular event that obstructs blood supply to the brain, producing irreversible damage that affects neurons but also glial and…”
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The structure and function of actin cytoskeleton in mature glutamatergic dendritic spines by Bellot, Alba, Guivernau, Biuse, Tajes, Marta, Bosch-Morató, Mònica, Valls-Comamala, Victòria, Muñoz, Francisco J

“…Abstract Dendritic spines are actin-rich protrusions from the dendritic shaft, considered to be the locus where most synapses occur, as they receive the vast…”
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Activation of PKR causes amyloid beta-peptide accumulation via De-Repression of Bace1 expression by Ill-Raga, Gerard, 1982, Palomer, Ernest, Wozniak, Matthew A, Ramos Fernández, Eva, 1984, Bosch Morató, Mònica, 1986, Tajes Orduña, Marta, Guix Ràfols, Francesc Xavier, Galán, José J, Clarimón Echevarría, Jordi, Antúnez, Carmen, Real, Luis M, Boada, Mercè, Itzhaki, Ruth F, Fandos, César, Muñoz López, Francisco José, 1964

“…BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively…”
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Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression by Ill-Raga, Gerard, Palomer, Ernest, Wozniak, Matthew A, Ramos-Fernández, Eva, Bosch-Morató, Mònica, Tajes, Marta, Guix, Francesc X, Galán, José J, Clarimón, Jordi, Antúnez, Carmen, Real, Luis M, Boada, Mercé, Itzhaki, Ruth F, Fandos, César, Muñoz, Francisco J

“…BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively…”
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Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis by Rubio-Moscardo, Fanny, Setó-Salvia, Núria, Pera, Marta, Bosch-Morató, Mònica, Plata, Cristina, Belbin, Olivia, Gené, Gemma, Dols-Icardo, Oriol, Ingelsson, Martin, Helisalmi, Seppo, Soininen, Hilkka, Hiltunen, Mikko, Giedraitis, Vilmantas, Lannfelt, Lars, Frank, Ana, Bullido, Ma Jesús, Combarros, Onofre, Sánchez-Juan, Pascual, Boada, Mercè, Tárraga, Lluís, Pastor, Pau, Pérez-Tur, Jordi, Baquero, Miquel, Molinuevo, José L, Sánchez-Valle, Raquel, Fuentes-Prior, Pablo, Fortea, Juan, Blesa, Rafael, Muñoz, Francisco J, Lleó, Alberto, Valverde, Miguel A, Clarimón, Jordi

“…Calcium signaling in the brain is fundamental to the learning and memory process and there is evidence to suggest that its dysfunction is involved in the…”
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The blood-brain barrier: structure, function and therapeutic approaches to cross it by Tajes, Marta, Ramos-Fernández, Eva, Weng-Jiang, Xian, Bosch-Morató, Mònica, Guivernau, Biuse, Eraso-Pichot, Abel, Salvador, Bertrán, Fernàndez-Busquets, Xavier, Roquer, Jaume, Muñoz, Francisco J

“…The blood-brain barrier (BBB) is constituted by a specialized vascular endothelium that interacts directly with astrocytes, neurons and pericytes. It protects…”
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Methylglyoxal reduces mitochondrial potential and activates Bax and caspase-3 in neurons: Implications for Alzheimer's disease by Tajes, Marta, Eraso-Pichot, Abel, Rubio-Moscardó, Fanny, Guivernau, Biuse, Bosch-Morató, Mònica, Valls-Comamala, Victòria, Muñoz, Francisco J.

“…•Amyloid induces methylglyoxal production.•Tyr modification of TPI is the cause of methylglyoxal production.•Methylglyoxal triggers neuronal apoptosis…”
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Amyloid-β peptide fibrils induce nitro-oxidative stress in neuronal cells by Ill-Raga, Gerard, Ramos-Fernández, Eva, Guix, Francesc X, Tajes, Marta, Bosch-Morató, Mónica, Palomer, Ernest, Godoy, Juan, Belmar, Sebastián, Cerpa, Waldo, Simpkins, James W, Inestrosa And, Nibaldo C, Muñoz, Francisco J

“…Different mechanisms including oxidative stress are proposed for amyloid-β peptide (Aβ) neurotoxicity, and here we contribute to demonstrate that…”
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Increased amyloid β-peptide uptake in skeletal muscle is induced by hyposialylation and may account for apoptosis in GNE myopathy by Bosch-Morató, Mònica, Iriondo, Cinta, Guivernau, Biuse, Valls-Comamala, Victòria, Vidal, Noemí, Olivé, Montse, Querfurth, Henry, Muñoz, Francisco J

“…GNE myopathy is an autosomal recessive muscular disorder of young adults characterized by progressive skeletal muscle weakness and wasting. It is caused by a…”
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Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons by Ramos-Fernández, Eva, Tajes, Marta, Ill-Raga, Gerard, Vargas, Lina, Busquets-García, Arnau, Bosch-Morató, Mònica, Guivernau, Biuse, Valls-Comamala, Victòria, Gomis, Maria, Grau, Cristina, Fandos, César, Rosen, Mark D, Rabinowitz, Michael H, Inestrosa, Nibaldo, Maldonado, Rafael, Altafaj, Xavier, Ozaita, Andrés, Alvarez, Alejandra, Vicente, Rubén, Valverde, Miguel A, Muñoz, Francisco J

“…The activation of N-Methyl D-Aspartate Receptor (NMDAR) by glutamate is crucial in the nervous system function, particularly in memory and learning. NMDAR is…”
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Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis by Rubio Moscardo, Fanny, Setó Salvia, Núria, Pera, Marta, Bosch Morató, Mònica, Plata, Cristina, Belbin, Olivia, Gené, Gemma, Dols Icardo, Oriol, Ingelsson, Martin, Helisalmi, Seppo, Soininen, Hilkka, Hiltunen, Mikko, Giedraitis, Vilmantas, Lannfelt, Lars, Frank, Ana, Bullido, M. Jesús, Combarros, Onofre, Sánchez Juan, Pascual, Boada, Mercè, Tárraga, Lluís, Pastor, Pau, Pérez Tur, Jordi, Baquero, Miquel, Molinuevo, José L, Sánchez del Valle Díaz, Raquel, Fuentes Prior, Pablo, Fortea Ormaechea, Juan, Blesa, Rafael, Muñoz, Francisco J, Lleó Bisa, Alberto, Valverde, Miguel A, Clarimón, Jordi

“…Calcium signaling in the brain is fundamental to the learning and memory process and there is evidence to suggest that its dysfunction is involved in the…”
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The pathophysiology of triose phosphate isomerase dysfunction in Alzheimer's disease by Tajes, M, Guivernau, B, Ramos-Fernández, E, Bosch-Morató, M, Palomer, E, Guix, F X, Muñoz, F J

“…Alzheimer's disease (AD), the most prevalent neurodegenerative disease worldwide, has two main hallmarks: extracellular deposits of amyloid β-peptide (Aβ) and…”
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