Search Results - "Bosch‐Barrera, Joaquim"

Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype by Cuyàs, Elisabet, Fernández-Arroyo, Salvador, Corominas-Faja, Bruna, Rodríguez-Gallego, Esther, Bosch-Barrera, Joaquim, Martin-Castillo, Begoña, De Llorens, Rafael, Joven, Jorge, Menendez, Javier A

“…Metabolic flexibility might be particularly constrained in tumors bearing mutations in isocitrate dehydrogenase 1 (IDH1) leading to the production of the…”
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LungBEAM: A prospective multicenter study to monitor stage IV NSCLC patients with EGFR mutations using BEAMing technology by Garrido, Pilar, Paz‐Ares, Luis, Majem, Margarita, Morán, Teresa, Trigo, José Manuel, Bosch‐Barrera, Joaquim, Garcίa‐Campelo, Rosario, González‐Larriba, José Luis, Sánchez‐Torres, José Miguel, Isla, Dolores, Viñolas, Núria, Camps, Carlos, Insa, Amelia, Juan, Óscar, Massuti, Bartomeu, Paredes, Alfredo, Artal, Ángel, López‐Brea, Marta, Palacios, José, Felip, Enriqueta

“…Objectives The aim of LungBEAM was to determine the value of a novel epidermal growth factor receptor (EGFR) mutation test in blood based on BEAMing technology…”
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STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis by Priego, Neibla, Zhu, Lucía, Monteiro, Cátia, Mulders, Manon, Wasilewski, David, Bindeman, Wendy, Doglio, Laura, Martínez, Liliana, Martínez-Saez, Elena, Ramón y Cajal, Santiago, Megías, Diego, Hernández-Encinas, Elena, Blanco-Aparicio, Carmen, Martínez, Lola, Zarzuela, Eduardo, Muñoz, Javier, Fustero-Torre, Coral, Piñeiro-Yáñez, Elena, Hernández-Laín, Aurelio, Bertero, Luca, Poli, Valeria, Sanchez-Martinez, Melchor, Menendez, Javier A., Soffietti, Riccardo, Bosch-Barrera, Joaquim, Valiente, Manuel

“…The brain microenvironment imposes a particularly intense selective pressure on metastasis-initiating cells, but successful metastases bypass this control…”
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Metformin: multi-faceted protection against cancer by Del Barco, Sonia, Vazquez-Martin, Alejandro, Cufí, Sílvia, Oliveras-Ferraros, Cristina, Bosch-Barrera, Joaquim, Joven, Jorge, Martin-Castillo, Begoña, Menendez, Javier A

“…The biguanide metformin, a widely used drug for the treatment of type 2 diabetes, may exert cancer chemopreventive effects by suppressing the transformative…”
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Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation by Cuyàs, Elisabet, Verdura, Sara, Llorach-Parés, Laura, Fernández-Arroyo, Salvador, Joven, Jorge, Martin-Castillo, Begoña, Bosch-Barrera, Joaquim, Brunet, Joan, Nonell-Canals, Alfons, Sanchez-Martinez, Melchor, Menendez, Javier A

“…Metformin has been proposed to operate as an agonist of SIRT1, a nicotinamide adenine dinucleotide (NAD )-dependent deacetylase that mimics most of the…”
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Silibinin Suppresses the Hyperlipidemic Effects of the ALK-Tyrosine Kinase Inhibitor Lorlatinib in Hepatic Cells by Verdura, Sara, Encinar, José Antonio, Fernández-Arroyo, Salvador, Joven, Jorge, Cuyàs, Elisabet, Bosch-Barrera, Joaquim, Menendez, Javier A

“…The third-generation anaplastic lymphoma tyrosine kinase inhibitor (ALK-TKI) lorlatinib has a unique side effect profile that includes hypercholesteremia and…”
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AZ12756122, a novel fatty acid synthase inhibitor, decreases resistance features in EGFR-TKI resistant EGFR-mutated NSCLC cell models by Polonio-Alcalá, Emma, Porta, Rut, Ruiz-Martínez, Santiago, Vásquez-Dongo, Carmen, Relat, Joana, Bosch-Barrera, Joaquim, Ciurana, Joaquim, Puig, Teresa

“…Different EGFR tyrosine kinase inhibitors (TKIs) have been developed for the treatment of non-small cell lung cancer (NSCLC) patients harboring sensitizing…”
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Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers by Pérez-Sánchez, Almudena, Cuyàs, Elisabet, Ruiz-Torres, Verónica, Agulló-Chazarra, Luz, Verdura, Sara, González-Álvarez, Isabel, Bermejo, Marival, Joven, Jorge, Micol, Vicente, Bosch-Barrera, Joaquim, Menendez, Javier A

“…An ever-growing number of preclinical studies have investigated the tumoricidal activity of the milk thistle flavonolignan silibinin. The clinical value of…”
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Epidemiology, treatment, and survival in small cell lung cancer in Spain: Data from the Thoracic Tumor Registry by Franco, Fernando, Carcereny, Enric, Guirado, Maria, Ortega, Ana L, López-Castro, Rafael, Rodríguez-Abreu, Delvys, García-Campelo, Rosario, del Barco, Edel, Juan, Oscar, Aparisi, Francisco, González-Larriba, Jose L, Domine, Manuel, Trigo, Jose M, Cobo, Manuel, Cerezo, Sara, Calzas, Julia, Massutí, Bartomeu, Bosch-Barrera, Joaquim, García Coves, Paola, Domènech, Marta, Provencio, Mariano

“…Background Small-cell lung cancer (SCLC) is an aggressive disease with high metastatic potential and poor prognosis. Due to its low prevalence, epidemiological…”
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Lung Cancer Management with Silibinin: A Historical and Translational Perspective by Verdura, Sara, Cuyàs, Elisabet, Ruiz-Torres, Verónica, Micol, Vicente, Joven, Jorge, Bosch-Barrera, Joaquim, Menendez, Javier A.

“…The flavonolignan silibinin, the major bioactive component of the silymarin extract of Silybum marianum (milk thistle) seeds, is gaining traction as a novel…”
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The role of multimorbidity in short-term mortality of lung cancer patients in Spain: a population-based cohort study by Niksic, Maja, Redondo-Sanchez, Daniel, Chang, Yoe-Ling, Rodriguez-Barranco, Miguel, Exposito-Hernandez, Jose, Marcos-Gragera, Rafael, Oliva-Poch, Ester, Bosch-Barrera, Joaquim, Sanchez, Maria-Jose, Luque-Fernandez, Miguel Angel

“…Chronic diseases often occur simultaneously and tend to be associated with adverse health outcomes, but limited research has been undertaken to understand…”
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ENDOLUNG trial. A phase 1/2 study of the Akt/mTOR inhibitor and autophagy inducer Ibrilatazar (ABTL0812) in combination with paclitaxel/carboplatin in patients with advanced/recurrent endometrial cancer by Leary, Alexandra, Estévez-García, Purificación, Sabatier, Renaud, Ray-Coquard, Isabelle, Romeo, Margarita, Barretina-Ginesta, Pilar, Gil-Martin, Marta, Garralda, Elena, Bosch-Barrera, Joaquim, Morán, Teresa, Martin-Martorell, Paloma, Nadal, Ernest, Gascón, Pere, Rodon, Jordi, Lizcano, Jose M, Muñoz-Guardiola, Pau, Fierro-Durán, Gemma, Pedrós-Gámez, Oriol, Pérez-Montoyo, Héctor, Yeste-Velasco, Marc, Cortal, Marc, Pérez-Campos, Antonio, Alfon, Jose, Domenech, Carles, Pérez-Fidalgo, Alejandro, Oaknin, Ana

“…Carboplatin and paclitaxel (CP) have been the standard of care for advanced/recurrent endometrial cancer (EC) for many years. However, this chemotherapy…”
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Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts by Cufi, Silvia, Corominas-Faja, Bruna, Vazquez-Martin, Alejandro, Oliveras-Ferraros, Christina, Dorca, Joan, Bosch-Barrera, Joaquim, Martin-Castillo, Begoña, Menendez, Javier A

“…Trastuzumab-refractory breast cancer stem cells (CSCs) could also explain the high rate of primary resistance to single-agent trastuzumab in HER2…”
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Correction: ENDOLUNG trial. A phase 1/2 study of the Akt/mTOR inhibitor and autophagy inducer Ibrilatazar (ABTL0812) in combination with paclitaxel/carboplatin in patients with advanced/recurrent endometrial cancer by Leary, Alexandra, Estévez-García, Purificación, Sabatier, Renaud, Ray-Coquard, Isabelle, Romeo, Margarita, Barretina-Ginesta, Pilar, Gil-Martin, Marta, Garralda, Elena, Bosch-Barrera, Joaquim, Morán, Teresa, Martin-Martorell, Paloma, Nadal, Ernest, Gascón, Pere, Rodon, Jordi, Lizcano, Jose M, Muéoz-Guardiola, Pau, Fierro-Durán, Gemma, Pedrós-Gámez, Oriol, Pérez-Montoyo, Héctor, Yeste-Velasco, Marc, Cortal, Marc, Pérez-Campos, Antonio, Alfon, Jose, Domenech, Carles, Pérez-Fidalgo, Alejandro, Oaknin, Ana

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Response of brain metastasis from lung cancer patients to an oral nutraceutical product containing silibinin by Bosch-Barrera, Joaquim, Sais, Elia, Cañete, Noemí, Marruecos, Jordi, Cuyàs, Elisabet, Izquierdo, Angel, Porta, Rut, Haro, Manel, Brunet, Joan, Pedraza, Salvador, Menendez, Javier A

“…Despite multimodal treatment approaches, the prognosis of brain metastases (BM) from non-small cell lung cancer (NSCLC) remains poor. Untreated patients with…”
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IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations by Vazquez-Martin, Alejandro, Cufí, Sílvia, Oliveras-Ferraros, Cristina, Torres-Garcia, Violeta Zenobia, Corominas-Faja, Bruna, Cuyàs, Elisabet, Bonavia, Rosa, Visa, Joana, Martin-Castillo, Begoña, Barrajón-Catalán, Enrique, Micol, Vicente, Bosch-Barrera, Joaquim, Menendez, Javier A.

“…Using non-small cell lung carcinoma (NSCLC) cells harboring the erlotinib-sensitizing Epidermal Growth Factor Receptor ( EGFR ) exon 19 mutation delE746-A750 ,…”
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Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A by Cuyàs, Elisabet, Gumuzio, Juan, Lozano-Sánchez, Jesús, Carreras, David, Verdura, Sara, Llorach-Parés, Laura, Sanchez-Martinez, Melchor, Selga, Elisabet, Pérez, Guillermo J, Scornik, Fabiana S, Brugada, Ramon, Bosch-Barrera, Joaquim, Segura-Carretero, Antonio, Martin, Ángel G, Encinar, José Antonio, Menendez, Javier A

“…The lysine-specific histone demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) is a central epigenetic regulator of metabolic…”
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Clinical Management of COVID-19 in Cancer Patients with the STAT3 Inhibitor Silibinin by Bosch-Barrera, Joaquim, Roqué, Ariadna, Teixidor, Eduard, Carmona-Garcia, Maria Carmen, Arbusà, Aina, Brunet, Joan, Martin-Castillo, Begoña, Cuyàs, Elisabet, Verdura, Sara, Menendez, Javier A

“…COVID-19 pathophysiology is caused by a cascade of respiratory and multiorgan failures arising, at least in part, from the SARS-CoV-2-driven dysregulation of…”
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Abstract 2746: Stat3 labels a subpopulation of reactive astrocytes required for brain metastasis by Priego, Neibla, Zhu, Lucía, Monteiro, Catia, Mulders, Manon, Wasilewski, David, Bindeman, Wendy, Doglio, Laura, Martínez-Saez, Elena, Cajal, Santiago Ramón y, Fustero-Torre, Coral, Piñeiro-Yáñez, Elena, Hernández-Laín, Aurelio, Poli, Valeria, Menéndez, Javier A., Soffietti, Ricardo, Bosch-Barrera, Joaquim, Valiente, Manuel

“…The diagnosis of brain metastasis involves high morbidity and mortality and remains as an unmet clinical need in spite of being the most common tumor in the…”
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Metformin lowers the threshold for stress-induced senescence: A role for the microRNA-200 family and miR-205 by Cufí, Sílvia, Vazquez-Martin, Alejandro, Oliveras-Ferraros, Cristina, Quirantes, Rosa, Segura-Carretero, Antonio, Micol, Vicente, Joven, Jorge, Bosch-Barrera, Joaquim, Del Barco, Sonia, Martin-Castillo, Begoña, Vellon, Luciano, Menendez, Javier A.

“…We have tested the hypothesis that the antidiabetic biguanide metformin can be used to manipulate the threshold for stress-induced senescence (SIS), thus…”
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