Search Results - "Bosch, Megan"

Neuroinflammatory paradigms in lysosomal storage diseases by Bosch, Megan E, Kielian, Tammy

“…Lysosomal storage diseases (LSDs) include approximately 70 distinct disorders that collectively account for 14% of all inherited metabolic diseases. LSDs are…”
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Astrocytes in juvenile neuronal ceroid lipofuscinosis (CLN3) display metabolic and calcium signaling abnormalities by Bosch, Megan E., Kielian, Tammy

“…Juvenile neuronal ceroid lipofuscinosis (JNCL) is a lysosomal storage disease caused by autosomal recessive mutations in ceroid lipofuscinosis 3 (CLN3)…”
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Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy by Xiong, Monica, Wang, Chao, Gratuze, Maud, Saadi, Fareeha, Bao, Xin, Bosch, Megan E, Lee, Choonghee, Jiang, Hong, Serrano, Javier Remolina, Gonzales, Ernesto R, Kipnis, Michal, Holtzman, David M

“…Alzheimer Disease (AD) and cerebral amyloid angiopathy (CAA) are both characterized by amyloid-β (Aβ) accumulation in the brain, although Aβ deposits mostly in…”
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Caspase 1 activity influences juvenile Batten disease (CLN3) pathogenesis by Burkovetskaya, Maria, Bosch, Megan E., Karpuk, Nikolay, Fallet, Rachel, Kielian, Tammy

“…Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) is an autosomal recessive lysosomal storage disease caused by loss‐of‐function mutations in CLN3. Symptoms…”
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Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection by Heim, Cortney E., Bosch, Megan E., Yamada, Kelsey J., Aldrich, Amy L., Chaudhari, Sujata S., Klinkebiel, David, Gries, Casey M., Alqarzaee, Abdulelah A., Li, Yixuan, Thomas, Vinai C., Seto, Edward, Karpf, Adam R., Kielian, Tammy

“…Staphylococcus aureus is a leading cause of biofilm-associated prosthetic joint infection (PJI), resulting in considerable disability and prolonged treatment…”
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Self-Complementary AAV9 Gene Delivery Partially Corrects Pathology Associated with Juvenile Neuronal Ceroid Lipofuscinosis (CLN3) by Bosch, Megan E, Aldrich, Amy, Fallet, Rachel, Odvody, Jessica, Burkovetskaya, Maria, Schuberth, Kaitlyn, Fitzgerald, Julie A, Foust, Kevin D, Kielian, Tammy

“…Juvenile neuronal ceroid lipofuscinosis (JNCL) is a fatal lysosomal storage disease caused by autosomal-recessive mutations in CLN3 for which no treatment…”
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Staphylococcus aureus ATP Synthase Promotes Biofilm Persistence by Influencing Innate Immunity by Bosch, Megan E, Bertrand, Blake P, Heim, Cortney E, Alqarzaee, Abdulelah A, Chaudhari, Sujata S, Aldrich, Amy L, Fey, Paul D, Thomas, Vinai C, Kielian, Tammy

“…is a major cause of prosthetic joint infection (PJI), which is characterized by biofilm formation. biofilm skews the host immune response toward an…”
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Efficacy of phosphodiesterase-4 inhibitors in juvenile Batten disease (CLN3) by Aldrich, Amy, Bosch, Megan E., Fallet, Rachel, Odvody, Jessica, Burkovetskaya, Maria, Rama Rao, Kakulavarapu V., Cooper, Jonathan D., Drack, Arlene V., Kielian, Tammy

“…Objective Juvenile neuronal ceroid lipofuscinosis (JNCL), or juvenile Batten disease, is a pediatric lysosomal storage disease caused by autosomal recessive…”
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Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner by Bosch, Megan E, Dodiya, Hemraj B, Michalkiewicz, Julia, Lee, Choonghee, Shaik, Shabana M, Weigle, Ian Q, Zhang, Can, Osborn, Jack, Nambiar, Aishwarya, Patel, Priyam, Parhizkar, Samira, Zhang, Xiaoqiong, Laury, Marie L, Mondal, Prasenjit, Gomm, Ashley, Schipma, Matthew John, Mallah, Dania, Butovsky, Oleg, Chang, Eugene B, Tanzi, Rudolph E, Gilbert, Jack A, Holtzman, David M, Sisodia, Sangram S

“…It has recently become well-established that there is a connection between Alzheimer's disease pathology and gut microbiome dysbiosis. We have previously…”
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Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner by Bosch, Megan E, Dodiya, Hemraj B, Michalkiewicz, Julia, Lee, Choonghee, Shaik, Shabana M, Weigle, Ian Q, Zhang, Can, Osborn, Jack, Nambiar, Aishwarya, Patel, Priyam, Parhizkar, Samira, Zhang, Xiaoqiong, Laury, Marie L, Mondal, Prasenjit, Gomm, Ashley, Schipma, Matthew John, Mallah, Dania, Butovsky, Oleg, Chang, Eugene B, Tanzi, Rudolph E, Gilbert, Jack A, Holtzman, David M, Sisodia, Sangram S

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Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration by Drieu, Antoine, Du, Siling, Kipnis, Michal, Bosch, Megan E, Herz, Jasmin, Lee, Choonghee, Jiang, Hong, Manis, Melissa, Ulrich, Jason D, Kipnis, Jonathan, Holtzman, David M, Gratuze, Maud

“…Parenchymal border macrophages (PBMs) reside close to the central nervous system parenchyma and regulate CSF flow dynamics. We recently demonstrated that PBMs…”
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AAV2/1 CD74 Gene Transfer Reduces β-amyloidosis and Improves Learning and Memory in a Mouse Model of Alzheimer's Disease by Kiyota, Tomomi, Zhang, Gang, Morrison, Christine M, Bosch, Megan E, Weir, Robert A, Lu, Yaman, Dong, Weiguo, Gendelman, Howard E

“…Modulation of the amyloid-β (Aβ) trafficking pathway heralds a new therapeutic frontier for Alzheimer's disease (AD). As CD74 binds to the amyloid-β precursor…”
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Evidence for aberrant astrocyte hemichannel activity in Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) by Burkovetskaya, Maria, Karpuk, Nikolay, Xiong, Juan, Bosch, Megan, Boska, Michael D, Takeuchi, Hideyuki, Suzumura, Akio, Kielian, Tammy

“…Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) is a lysosomal storage disease caused by an autosomal recessive mutation in CLN3 that leads to vision loss,…”
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Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist by Litvinchuk, Alexandra, Suh, Jung H, Guo, Jing L, Lin, Karin, Davis, Sonnet S, Bien-Ly, Nga, Tycksen, Eric, Tabor, G Travis, Remolina Serrano, Javier, Manis, Melissa, Bao, Xin, Lee, Choonghee, Bosch, Megan, Perez, Enmanuel J, Yuede, Carla M, Cashikar, Anil G, Ulrich, Jason D, Di Paolo, Gilbert, Holtzman, David M

“…Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease (LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3…”
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Paula Burnett. The EmLit Project: European Minority Literatures in Translation by Bosch, Megan E

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Hemichannels in neurodegenerative diseases: is there a link to pathology? by Bosch, Megan, Kielian, Tammy

“…Although originally considered a structural component of gap junctions, connexin hemichannels (HCs) are now recognized as functional entities capable of…”
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Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogram the host immune response during persistent infection by Heim, Cortney, Bosch, Megan E, Yamada, Kelsey J, Aldrich, Amy L, Chaudhari, Sujata S, Klinkebiel, David, Gries, Casey M, Alqarzaee, Abdulelah A, Li, Yixuan, Thomas, Vinai C, Seto, Edward, Kielian, Tammy

“…Staphylococcus aureus (S. aureus) is a leading cause of prosthetic joint infection (PJI) typified by biofilm formation. Our laboratory has identified…”
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Staphylococcus aureus biofilm-derived lactate inhibits HDAC11 to augment leukocyte IL-10 production and promote infection persistence by Heim, Cortney, Bosch, Megan E, Yamada, Kelsey J, Aldrich, Amy L, Chaudhari, Sujata S, Klinkebiel, David, Gries, Casey M, Alqarzaee, Abdulelah A, Li, Yixuan, Seto, Edward, Karpf, Adam R, Kielian, Tammy

“…Staphylococcus aureus (S. aureus) is a leading cause of biofilm-associated prosthetic joint infections (PJIs), where leukocyte IL-10 production is critical for…”
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Adeno-associated virus 9 gene therapy for juvenile neuronal ceroid lipofuscinosis by Kielian, Tammy, Bosch, Megan E., Aldrich, Amy, Fallet, Rachel, Foust, Kevin D.

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AAV2/1 CD74 Gene Transfer Reduces [beta]-amyloidosis and Improves Learning and Memory in a Mouse Model of Alzheimer's Disease by Kiyota, Tomomi, Zhang, Gang, Morrison, Christine M, Bosch, Megan E, Weir, Robert A, Lu, Yaman, Dong, Weiguo, Gendelman, Howard E

“…Modulation of the amyloid-β (Aβ) trafficking pathway heralds a new therapeutic frontier for Alzheimer's disease (AD). As CD74 binds to the amyloid-β precursor…”
Get full text