Search Results - "Bosch, Marnix"

External Control Arms and Data Analysis Methods in Nonrandomized Trial of Patients With Glioblastoma-Reply by Liau, Linda M, Ashkan, Keyoumars, Bosch, Marnix L

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Cytokines Produced by Dendritic Cells Administered Intratumorally Correlate with Clinical Outcome in Patients with Diverse Cancers by Subbiah, Vivek, Murthy, Ravi, Hong, David S, Prins, Robert M, Hosing, Chitra, Hendricks, Kyle, Kolli, Deepthi, Noffsinger, Lori, Brown, Robert, McGuire, Mary, Fu, Siquing, Piha-Paul, Sarina, Naing, Aung, Conley, Anthony P, Benjamin, Robert S, Kaur, Indreshpal, Bosch, Marnix L

“…Dendritic cells (DC) initiate adaptive immune responses through the uptake and presentation of antigenic material. In preclinical studies, intratumorally…”
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ITOC2 – 017. Prolonged survival for patients with recurrent glioblastoma multiforme who are treated with tumour lysate-pulsed autologous dendritic cells by Marnix, Bosch L, Robert, Prins M, Linda, Liau

“…Background Recurrent glioblastoma multiforme (rGBM) is a life threatening condition, with a mortality rate of approximately 100%. Despite recent advances in…”
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Current methods for loading dendritic cells with tumor antigen for the induction of antitumor immunity by YALING ZHOU, BOSCH, Marnix L, SALGALLER, Michael L

“…The immunotherapy of cancer is predicated on the belief that it is possible to generate a clinically meaningful antitumor response that provides patient…”
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Interferon-gamma Added During Bacillus Calmette-Guerin Induced Dendritic Cell Maturation Stimulates Potent Th1 Immune Responses by Shankar, Gopi, Pestano, Linda A, Bosch, Marnix L

“…Dendritic cells (DC) are increasingly prepared in vitro for use in immunotherapy trials. Mature DC express high levels of surface molecules needed for T cell…”
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A novel series of conferences tackling the hurdles confronting the translation of novel cancer immunotherapies by Bot, Adrian, Ahn, Mark, Bosch, Marnix, Brockstedt, Dirk, Butterfield, Lisa H, Cornforth, Andrew, Harrop, Richard, Kast, W Martin, Koya, Richard, Marincola, Francesco, Margolin, Kim, McCoy, Candice, Pawelec, Graham, Rothman, John, Ramirez-Montagut, Teresa, Schlom, Jeffrey, Srivastava, Pramod, Wallis, Sarah, Walter, Steffen, Wang, Ena, Waslif, John

“…While there has been significant progress in advancing novel immune therapies to the bedside, much more needs to be done to fully tap into the potential of the…”
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CTIM-15. T CELL RESPONSE DYNAMICS IN PHASE 3 GLIOBLASTOMA PATIENTS IMMUNIZED WITH AUTOLOGOUS DENDRITIC CELLS PULSED WITH AUTOLOGOUS TUMOR CELL LYSATE by Bosch, Marnix, Liau, Linda, Ashkan, Keyoumars

“…Abstract BACKGROUND 331 glioblastoma patients were immunized with autologous dendritic cells (DCs) pulsed with autologous tumor cell lysate or placebo in a…”
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Induction of Potent Human Immunodeficiency Virus Type 1-Specific T-Cell-Restricted Immunity by Genetically Modified Dendritic Cells by Lisziewicz, J, Gabrilovich, D I, Varga, G, Xu, J, Greenberg, P D, Arya, S K, Bosch, M, Behr, J P, Lori, F

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Novel Kaposi's Sarcoma-Associated Herpesvirus Homolog in Baboons by Whitby, Denise, Stossel, Andrea, Gamache, Christine, Papin, James, Bosch, Marnix, Smith, Anne, Kedes, Dean H, White, Gary, Kennedy, Ronald, Dittmer, Dirk P

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Identification of the Fusion Peptide of Primate Immunodeficiency Viruses by Bosch, Marnix L., Earl, Patricia L., Fargnoli, Kathleen, Picciafuoco, Silvia, Giombini, Fabrizio, Wong-Staal, Flossie, Franchini, Genoveffa

“…Membrane fusion induced by the envelope glycoproteins of human and simian immunodeficiency viruses (HIV and SIV$_{\text{mac}}$) is a necessary step for the…”
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Detection of Kaposi's Sarcoma—Associated Herpesvirus in Oral and Genital Secretions of Zimbabwean Women by Lampinen, Thomas M., Kulasingam, Shalini, Min, Juno, Borok, Margaret, Gwanzura, Lovemore, Lamb, Julie, Mahomed, Kassam, Woelk, Godfrey B., Strand, Kurt B., Bosch, Marnix L., Edelman, Daniel C., Constantine, Niel T., Katzenstein, David, Williams, Michelle A.

“…Kaposi's sarcoma—associated herpesvirus (KSHV) in oral and genital secretions of women may be involved in horizontal and vertical transmission in endemic…”
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Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A Phase 3 Prospective Externally Controlled Cohort Trial by Liau, Linda M, Ashkan, Keyoumars, Brem, Steven, Campian, Jian L, Trusheim, John E, Iwamoto, Fabio M, Tran, David D, Ansstas, George, Cobbs, Charles S, Heth, Jason A, Salacz, Michael E, D'Andre, Stacy, Aiken, Robert D, Moshel, Yaron A, Nam, Joo Y, Pillainayagam, Clement P, Wagner, Stephanie A, Walter, Kevin A, Chaudhary, Rekha, Goldlust, Samuel A, Lee, Ian Y, Bota, Daniela A, Elinzano, Heinrich, Grewal, Jai, Lillehei, Kevin, Mikkelsen, Tom, Walbert, Tobias, Abram, Steven, Brenner, Andrew J, Ewend, Matthew G, Khagi, Simon, Lovick, Darren S, Portnow, Jana, Kim, Lyndon, Loudon, William G, Martinez, Nina L, Thompson, Reid C, Avigan, David E, Fink, Karen L, Geoffroy, Francois J, Giglio, Pierre, Gligich, Oleg, Krex, Dietmar, Lindhorst, Scott M, Lutzky, Jose, Meisel, Hans-Jörg, Nadji-Ohl, Minou, Sanchin, Lhagva, Sloan, Andrew, Taylor, Lynne P, Wu, Julian K, Dunbar, Erin M, Etame, Arnold B, Kesari, Santosh, Mathieu, David, Piccioni, David E, Baskin, David S, Lacroix, Michel, May, Sven-Axel, New, Pamela Z, Pluard, Timothy J, Toms, Steven A, Tse, Victor, Peak, Scott, Villano, John L, Battiste, James D, Mulholland, Paul J, Pearlman, Michael L, Petrecca, Kevin, Schulder, Michael, Prins, Robert M, Boynton, Alton L, Bosch, Marnix L

“…Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed. To investigate whether…”
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Abstract 2491: Treatment with tumor lysate-pulsed autologous dendritic cells prolongs survival in patients with recurrent glioblastoma multiforme by Bosch, Marnix, Prins, Robert, Liau, Linda

“…Abstract Background The survival rate in recurrent Glioblastoma multiforme (rGBM) patients has not meaningfully changed in the past several decades. We have…”
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Two distinct lineages of macaque γ herpesviruses related to the Kaposi’s sarcoma associated herpesvirus by Strand, Kurt, Harper, Erin, Thormahlen, Sherri, Thouless, Margaret E, Tsai, Che-Chung, Rose, Tim, Bosch, Marnix L

“…Background: KSHV, Kaposi’s sarcoma-associated herpesvirus, is a necessary cofactor for the development of Kaposi’s sarcoma (KS). We have previously reported…”
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Dendritic cells efficiently acquire and present antigen derived from lung cancer cells and induce antigen-specific T-cell responses by YALING ZHOU, MCEARCHERN, Julie A, HOWARD, Edward, PESTANO, Gary, SALGALLER, Michael L, BOSCH, Marnix L

“…Active immunotherapy of cancer requires the availability of a source of tumor antigens. To date, no such antigen associated with lung cancer has been…”
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Evidence for immune-mediated reduction of viral replication in Macaca nemestrina mucosally immunized with inactivated SHIV89.6 by Ambrose, Zandrea, Thompson, Jannelle, Larsen, Kay, Kuller, Larene, Panicali, Dennis L, Clements, John D, Agy, Michael, Montefiori, David C, Hu, Shiu-Lok, Bosch, Marnix L

“…Although most HIV-1 infections worldwide result from heterosexual transmission, most vaccine candidates have focused on induction of systemic immunity and…”
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Local and systemic antitumor effects of activated autologous dendritic cells for intratumoral injection: A phase I/II trial by Subbiah, Vivek, Murthy, Ravi, Kayaleh, Omar, Bosch, Marnix Leo

“…Abstract only…”
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Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer by Kandalaft, Lana E., Powell, Jr, Daniel J., Chiang, Cheryl L., Tanyi, Janos, Kim, Sarah, Bosch, Marnix, Montone, Kathy, Mick, Rosemarie, Levine, Bruce L., Torigian, Drew A., June, Carl H., Coukos, George

“…Novel strategies for the therapy of recurrent ovarian cancer are warranted. We report a study of a combinatorial approach encompassing dendritic cell…”
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CTIM-27. AUTOLOGOUS TUMOR LYSATE-LOADED DENDRITIC CELL VACCINATION IMPROVES SURVIVAL IN PATIENTS WITH NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA: SURVIVAL RESULTS FROM A PHASE 3 TRIAL by Liau, Linda M, Ashkan, Keyoumars, Brem, Steven, Campian, Jian, Trusheim, John, Iwamoto, Fabio, Tran, David, Anstass, George, Cobbs, Charles, Heth, Jason, Salacz, Michael, D'Andre, Stacy, Aiken, Robert, Moshel, Yaron, Nam, JooYeon, Pillainayagam, Clement, Wagner, Stephanie, Walter, Kevin, Chaudary, Rekha, Goldlust, Samuel, Lee, Ian, Bota, Daniela, Elinzano, Heinrich, Grewal, Jai, Lillehei, Kevin, Mikkelsen, Tom, Walbert, Tobias, Abram, Steve, Brenner, Andrew, Ewend, Matthew, Khagi, Simon, Lovick, Darren, Portnow, Jana, Kim, Lyndon, Loudon, William, Martinez, Nina, Thompson, Reid, Avigan, David, Fink, Karen, Geoffroy, Francois, Giglio, Pierre, Gligich, Oleg, Krex, Dietmar, Lindhorst, Scott M, Lutzky, Jose, Meisel, Hans-Joerg, Nadji-Ohl, Minou, Sanchin, Lhagva, Sloan, Andrew, Bosch, Marnix

“…Abstract BACKGROUND Standard of care (SOC) and patient survival in glioblastoma have changed little in the past 17 years. We evaluated in a phase 3 trial…”
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Evidence for Early Local Viral Replication and Local Production of Antiviral Immunity upon Mucosal Simian-Human Immunodeficiency Virus SHIV89.6 Infection in Macaca nemestrina by Ambrose, Zandrea, Larsen, Kay, Thompson, Jannelle, Stevens, Yvonne, Finn, Eric, Hu, Shiu-Lok, Bosch, Marnix L.

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