Search Results - "Bosca, Serena"

On the use of model-based tools to optimize in-line a pharmaceuticals freeze-drying process by Bosca, Serena, Barresi, Antonello, Fissore, Davide

“…This article is focused on the use of model-based tools to design and optimize in-line a pharmaceutical freeze-drying process. Two control systems have been…”
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Design and validation of an innovative soft-sensor for pharmaceuticals freeze-drying monitoring by Bosca, Serena, Fissore, Davide

“…The paper is focused on the development of a Kalman filter type observer for the monitoring of the primary drying phase of the freeze-drying of pharmaceutical…”
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The analysis and management of unsafe acts and unsafe conditions. Data collection and analysis by Baldissone, Gabriele, Comberti, Lorenzo, Bosca, Serena, Murè, Salvina

“…•This paper proposes an incidents precursor management system for accident prevention purposes.•A system for the data collection and classification is…”
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Reliability Assessment in a Freeze-Drying Process by Bosca, Serena, Fissore, Davide, Demichela, Micaela

“…A risk analysis for a pilot scale-freeze-dryer is shown in this paper, aiming to build the basis for the risk-based decision making in plant and process design…”
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Risk-Based Design of a Freeze-Drying Cycle for Pharmaceuticals by Bosca, Serena, Fissore, Davide, Demichela, Micaela

“…This paper is focused on the development of a new methodology to determine the design space of a drug freeze-drying process through a risk-based approach,…”
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Use of a soft sensor for the fast estimation of dried cake resistance during a freeze-drying cycle by Bosca, Serena, Barresi, Antonello A., Fissore, Davide

“…This paper deals with the determination of dried cake resistance in a freeze-drying process using the Smart Soft Sensor, a process analytical technology…”
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Fast freeze-drying cycle design and optimization using a PAT based on the measurement of product temperature by Bosca, Serena, Barresi, Antonello A., Fissore, Davide

“…This paper is focused on the use of an innovative Process Analytical Technology for the fast design and optimization of freeze-drying cycles for…”
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Design of a Robust Soft-Sensor to Monitor In-Line a Freeze-Drying Process by Bosca, Serena, Barresi, Antonello A., Fissore, Davide

“…This article deals with the in-line monitoring of a vital freeze-drying process using a soft-sensor that couples the experimental measurement of product…”
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On the robustness of the soft sensors used to monitor a vial freeze-drying process by Bosca, Serena, Barresi, Antonello A., Fissore, Davide

“…Process monitoring is a key issue in pharmaceutical freeze-drying to evaluate if the limit product temperature is approached, to identify the ending point of…”
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Use of soft sensors to monitor a pharmaceuticals freeze-drying process in vials by Bosca, Serena, Barresi, Antonello A., Fissore, Davide

“…Abstract Purpose: This paper presents a soft sensor that can be effectively used for in-line monitoring of the primary drying step of a pharmaceuticals…”
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Monitoring of a Pharmaceuticals Freeze-Drying Process by Model-Based Process Analytical Technology Tools by Bosca, Serena, Fissore, Davide

“…Pharmaceuticals freeze‐drying requires a careful monitoring to preserve product quality. This is a challenging task as it is not possible to measure inline the…”
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Freeze-Drying Monitoring Using a New Process Analytical Technology: Toward a "Zero Defect" Process by Bosca, Serena, Corbellini, Simone, Barresi, Antonello A., Fissore, Davide

“…This article presents a new process analytical technology to monitor a vial freeze-drying process taking into account the batch nonuniformity. It is based on a…”
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