Search Results - "Bosc, Elodie"
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Piperlongumine and some of its analogs inhibit selectively the human immunoproteasome over the constitutive proteasome
Published in Biochemical and biophysical research communications (12-02-2018)“…The natural small molecule piperlongumine A is toxic selectively to cancer cells in vitro and in vivo. This toxicity has been correlated with cancer cell ROS,…”
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2
Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics
Published in Cell death & disease (15-11-2022)“…Caspase-2 (Casp2) is a promising therapeutic target in several human diseases, including nonalcoholic steatohepatitis (NASH) and Alzheimer’s disease (AD)…”
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Inhibition of the Inflammasome NLRP3 by Arglabin Attenuates Inflammation, Protects Pancreatic β-Cells from Apoptosis, and Prevents Type 2 Diabetes Mellitus Development in ApoE2Ki Mice on a Chronic High-Fat Diet
Published in The Journal of pharmacology and experimental therapeutics (01-06-2016)“…Intraperitoneal injection of arglabin (2.5 ng/g of body weight, twice daily, 13 weeks) into female human apolipoprotein E2 gene knock-in (ApoE2Ki) mice fed a…”
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Pyrido-imidazodiazepinones as a new class of reversible inhibitors of human kallikrein 7
Published in European journal of medicinal chemistry (26-03-2015)“…The human tissue kallikrein-7 (KLK7) is a chymotryptic serine protease member of tissue kallikrein family. KLK7 is involved in skin homeostasis and…”
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