Search Results - "Bos, Sophie"

Function-specific IL-17A and dexamethasone interactions in primary human airway epithelial cells by Rahmawati, Siti Farah, Vos, Rémon, Bos, I. Sophie T., Kerstjens, Huib A. M., Kistemaker, Loes E. M., Gosens, Reinoud

“…Asthmatics have elevated levels of IL-17A compared to healthy controls. IL-17A is likely to contribute to reduced corticosteroid sensitivity of human airway…”
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Noncanonical WNT‐5A signaling regulates TGF‐β‐induced extracellular matrix production by airway smooth muscle cells by Kumawat, Kuldeep, Menzen, Mark H., Bos, I. Sophie T., Baarsma, Hoeke A., Borger, Pieter, Roth, Michael, Tamm, Michael, Halayko, Andrew J., Simoons, Mirjam, Prins, Alita, Postma, Dirkje S., Schmidt, Martina, Gosens, Reinoud

“…Transforming growth factor β (TGF‐β), a key mediator of fibrotic responses, is increased in asthma and drives airway remodeling by inducing expression of…”
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Bronchoprotection by olodaterol is synergistically enhanced by tiotropium in a guinea pig model of allergic asthma by Smit, Marieke, Zuidhof, Annet B, Bos, Sophie I T, Maarsingh, Harm, Gosens, Reinoud, Zaagsma, Johan, Meurs, Herman

“…The novel once-daily β₂-agonist bronchodilator drug olodaterol has recently been shown to be effective in patients with allergic asthma for >24 hours. An…”
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Muscarinic M₃ receptors contribute to allergen-induced airway remodeling in mice by Kistemaker, Loes E M, Bos, Sophie T, Mudde, Willemieke M, Hylkema, Machteld N, Hiemstra, Pieter S, Wess, Jürgen, Meurs, Herman, Kerstjens, Huib A M, Gosens, Reinoud

“…Asthma is a chronic obstructive airway disease, characterized by inflammation and remodeling. Acetylcholine contributes to symptoms by inducing…”
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Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma by Kistemaker, Loes E M, Bos, I Sophie T, Menzen, Mark H, Maarsingh, Harm, Meurs, Herman, Gosens, Reinoud

“…The long-acting anticholinergic tiotropium has recently been registered for the treatment of asthma, and its use is associated with a reduction in exacerbation…”
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Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation by Koopmans, Tim, Hesse, Laura, Nawijn, Martijn C., Kumawat, Kuldeep, Menzen, Mark H., Sophie T. Bos, I., Smits, Ron, Bakker, Elvira R. M., van den Berge, Maarten, Koppelman, Gerard H., Guryev, Victor, Gosens, Reinoud

“…Asthma is a heterogeneous disease characterized by chronic inflammation and structural changes in the airways. The airway smooth muscle (ASM) is responsible…”
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The novel TRPA1 antagonist BI01305834 inhibits ovalbumin-induced bronchoconstriction in guinea pigs by van den Berg, Mariska P M, Nijboer-Brinksma, Susan, Bos, I Sophie T, van den Berge, Maarten, Lamb, David, van Faassen, Martijn, Kema, Ido P, Gosens, Reinoud, Kistemaker, Loes E M

“…Asthma is a chronic respiratory disease in which the nervous system plays a central role. Sensory nerve activation, amongst others via Transient Receptor…”
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Cholinergic neuroplasticity in asthma driven by TrkB signaling by Dragunas, Guilherme, Woest, Manon E., Nijboer, Susan, Bos, Sophie T., Asselt, Janet, Groot, Anne P., Vohlídalová, Eva, Vermeulen, Corneel J., Ditz, Benedikt, Vonk, Judith M., Koppelman, Gerard H., den Berge, Maarten, ten Hacken, Nick H. T., Timens, Wim, Munhoz, Carolina D., Prakash, Y. S., Gosens, Reinoud, Kistemaker, Loes E. M.

“…Parasympathetic neurons in the airways control bronchomotor tone. Increased activity of cholinergic neurons are mediators of airway hyperresponsiveness (AHR)…”
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Protective Effects of Tiotropium Bromide in the Progression of Airway Smooth Muscle Remodeling by Gosens, Reinoud, Bos, I. Sophie T, Zaagsma, Johan, Meurs, Herman

“…Recent findings have demonstrated that muscarinic M(3) receptor stimulation enhances airway smooth muscle proliferation to peptide growth factors in vitro…”
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Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors by Wu, Xinhui, van Dijk, Eline M, Ng-Blichfeldt, John-Poul, Bos, I Sophie T, Ciminieri, Chiara, Königshoff, Melanie, Kistemaker, Loes E M, Gosens, Reinoud

“…Chronic obstructive pulmonary disease (COPD) represents a worldwide concern with high morbidity and mortality, and is believed to be associated with…”
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HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice by Leus, Niek G. J., van den Bosch, Thea, van der Wouden, Petra E., Krist, Kim, Ourailidou, Maria E., Eleftheriadis, Nikolaos, Kistemaker, Loes E. M., Bos, Sophie, Gjaltema, Rutger A. F., Mekonnen, Solomon A., Bischoff, Rainer, Gosens, Reinoud, Haisma, Hidde J., Dekker, Frank J.

“…Chronic obstructive pulmonary disease (COPD) constitutes a major health burden. Studying underlying molecular mechanisms could lead to new therapeutic targets…”
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Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells by Kistemaker, Loes E M, Hiemstra, Pieter S, Bos, I Sophie T, Bouwman, Susanne, van den Berge, Maarten, Hylkema, Machteld N, Meurs, Herman, Kerstjens, Huib A M, Gosens, Reinoud

“…It has been shown that acetylcholine is both a neurotransmitter and acts as a local mediator, produced by airway cells including epithelial cells. In vivo…”
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Arginase Inhibition Protects against Allergen-induced Airway Obstruction, Hyperresponsiveness, and Inflammation by Maarsingh, Harm, Zuidhof, Annet B, Bos, I. Sophie T, van Duin, Marcel, Boucher, Jean-Luc, Zaagsma, Johan, Meurs, Herman

“…In a guinea pig model of allergic asthma, using perfused tracheal preparations ex vivo, we demonstrated that L-arginine limitation due to increased arginase…”
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Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke by Oldenburger, Anouk, Timens, Wim, Bos, Sophie, Smit, Marieke, Smrcka, Alan V., Laurent, Anne‐Coline, Cao, Junjun, Hylkema, Machteld, Meurs, Herman, Maarsingh, Harm, Lezoualc'h, Frank, Schmidt, Martina

“…Cigarette smoke (CS) induces inflammatory responses characterized by increase of immune cells and cytokine release. Remodeling processes, such as mucus…”
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Caveolae and caveolins in the respiratory system by Gosens, Reinoud, Mutawe, Mark, Martin, Sarah, Basu, Sujata, Bos, Sophie T, Tran, Thai, Halayko, Andrew J

“…Caveolae are flask-shaped invaginations of the plasma membrane that are present in most structural cells. They owe their characteristic Omega-shape to…”
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The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation by Schaafsma, Dedmer, Bos, I Sophie T, Zuidhof, Annet B, Zaagsma, Johan, Meurs, Herman

“…Recently, we have shown that allergen-induced airway hyperresponsiveness (AHR) after the early (EAR) and late (LAR) asthmatic reaction in guinea pigs could be…”
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Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo by Van Eck, Miranda, Hoekstra, Menno, Out, Ruud, Bos, I. Sophie T., Kruijt, J. Kar, Hildebrand, Reeni B., Van Berkel, Theo J.C.

“…Scavenger receptor class B type I (SR-BI) functions as an HDL receptor that promotes the selective uptake of cholesteryl esters (CEs). The physiological role…”
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The Integrin-blocking Peptide RGDS Inhibits Airway Smooth Muscle Remodeling in a Guinea Pig Model of Allergic Asthma by DEKKERS, Bart G. J, BOS, I. Sophie T, GOSENS, Reinoud, HALAYKO, Andrew J, ZAAGSMA, Johan, MEURS, Herman

“…Airway remodeling, including increased airway smooth muscle (ASM) mass and contractility, contributes to airway hyperresponsiveness in asthma. The mechanisms…”
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Functional consequences of human airway smooth muscle phenotype plasticity by Dekkers, Bart GJ, Bos, I Sophie T, Zaagsma, Johan, Meurs, Herman

“…BACKGROUND AND PURPOSE Airway smooth muscle (ASM) phenotype plasticity, characterized by reversible switching between contractile and proliferative phenotypes,…”
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Dual Role for Scavenger Receptor Class B, Type I on Bone Marrow-Derived Cells in Atherosclerotic Lesion Development by Van Eck, Miranda, Bos, I. Sophie T., Hildebrand, Reeni B., Van Rij, Brechje T., Van Berkel, Theo J.C.

“…The function of scavenger receptor class B, type I (SR-BI) in the liver as a high-density lipoprotein receptor that promotes the selective uptake of…”
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