Search Results - "Bos, Gerard M.J"

Expression of tumor-associated differentiation antigens, MUC1 glycoforms and CEA, in human thymic epithelial cells : Implications for self-tolerance and tumor therapy by CLOOSEN, Silvie, ARNOLD, Janna, THIO, Marco, BOS, Gerard M. J, KYEWSKI, Bruno, GERMERAAD, Wilfred T. V

“…Expression of tissue-restricted self-antigens in the thymus, termed promiscuous gene expression, imposes T cell tolerance and protects from autoimmune…”
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Bortezomib Induction and Maintenance Treatment in Patients With Newly Diagnosed Multiple Myeloma: Results of the Randomized Phase III HOVON-65/ GMMG-HD4 Trial by SONNEVELD, Pieter, SCHMIDT-WOLF, Ingo G. H, WEISEL, Katja C, WITTEBOL, Shulamiet, BOS, Gerard M. J, STEVENS-KROEF, Marian, SCHEID, Christof, PFREUNDSCHUH, Michael, HOSE, Dirk, JAUCH, Anna, DER VELDE, Helgi Van, RAYMAKERS, Reinier, DER HOLT, Bronno Van, SCHAAFSMA, Martijn R, KERSTEN, Marie-Jose, MARWIJK-KOOY, Marinus Van, DUEHRSEN, Ulrich, LINDEMANN, Walter, WIJERMANS, Pierre W, LOKHORST, Henk M, GOLDSCHMIDT, Hartmut M, EL JARARI, Laila, BERTSCH, Uta, SALWENDER, Hans, ZWEEGMAN, Sonja, VELLENGA, Edo, BROYL, Annemiek, BLAU, Igor W

“…We investigated whether bortezomib during induction and maintenance improves survival in newly diagnosed multiple myeloma (MM). In all, 827 eligible patients…”
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The Effect of Vitamin C (Ascorbic Acid) in the Treatment of Patients with Cancer: A Systematic Review by van Gorkom, Gwendolyn N Y, Lookermans, Eline L, Van Elssen, Catharina H M J, Bos, Gerard M J

“…Many cancer patients on intensive chemotherapy lack vitamin C. Vitamin C stimulates the production and activation of immune cells, so perhaps supplementation…”
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A comprehensive overview of FCGR3A gene variability by full-length gene sequencing including the identification of V158F polymorphism by Mahaweni, Niken M., Olieslagers, Timo I., Rivas, Ivan Olivares, Molenbroeck, Stefan J. J., Groeneweg, Mathijs, Bos, Gerard M. J., Tilanus, Marcel G. J., Voorter, Christina E. M., Wieten, Lotte

“…The FCGR3A gene encodes for the receptor important for antibody-dependent natural killer cell-mediated cytotoxicity. FCGR3A gene polymorphisms could affect the…”
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Cereblon loss and up-regulation of c-Myc are associated with lenalidomide resistance in multiple myeloma patients by Franssen, Laurens E, Nijhof, Inger S, Couto, Suzana, Levin, Mark-David, Bos, Gerard M J, Broijl, Annemiek, Klein, Saskia K, Ren, Yan, Wang, Maria, Koene, Harry R, Bloem, Andries C, Beeker, Aart, Faber, Laura M, van der Spek, Ellen, Raymakers, Reinier, Leguit, Roos J, Sonneveld, Pieter, Zweegman, Sonja, Lokhorst, Henk, Mutis, Tuna, Thakurta, Anjan, Qian, Xiaozhong, van de Donk, Niels W C J

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Rosuvastatin Enhances VSV-G Lentiviral Transduction of NK Cells via Upregulation of the Low-Density Lipoprotein Receptor by Gong, Ying, Klein Wolterink, Roel G.J., Janssen, Ian, Groot, Arjan J., Bos, Gerard M.J., Germeraad, Wilfred T.V.

“…Adoptive natural killer (NK) cell therapy is attaining promising clinical outcomes in recent years, but improvements are needed. Genetic modification of NK…”
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Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy by Huijskens, Mirelle J.A.J, Walczak, Mateusz, Sarkar, Subhashis, Atrafi, Florance, Senden-Gijsbers, Birgit L.M.G, Tilanus, Marcel G.J, Bos, Gerard M.J, Wieten, Lotte, Germeraad, Wilfred T.V

“…Abstract Background aims Natural killer (NK) cell–based immunotherapy is a promising treatment for a variety of malignancies. However, generating sufficient…”
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Medical students perceive better group learning processes when large classes are made to seem small by Hommes, Juliette, Arah, Onyebuchi A, de Grave, Willem, Schuwirth, Lambert W T, Scherpbier, Albert J J A, Bos, Gerard M J

“…Medical schools struggle with large classes, which might interfere with the effectiveness of learning within small groups due to students being unfamiliar to…”
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Pathogen-Associated Molecular Patterns Induced Crosstalk between Dendritic Cells, T Helper Cells, and Natural Killer Helper Cells Can Improve Dendritic Cell Vaccination by Bos, Gerard M. J., Van Elssen, Catharina H. M. J., Vanderlocht, Joris, Oth, Tammy, Germeraad, Wilfred T. V.

“…A coordinated cellular interplay is of crucial importance in both host defense against pathogens and malignantly transformed cells. The various interactions of…”
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The Next Step Toward Patient-Centeredness in Multidisciplinary Cancer Team Meetings: An Interview Study with Professionals by Geerts, Paulus A F, van der Weijden, Trudy, Savelberg, Wilma, Altan, Melis, Chisari, Giorgio, Launert, Diana Ricarda, Mesters, Hannah, Pisters, Ylva, van Heumen, Mike, Hermanns, Raoul, Bos, Gerard M J, Moser, Albine

“…Patient-centeredness is essential in complex oncological multidisciplinary team decision-making. Improvement seems to be needed, while there is a lack of…”
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The Perception of Shared Decision‐Making in Hematology by Patients and Physicians Seems Satisfactory, but Important Steps are Still Ahead of Us by Geerts, Paulus A.F., Weijden, Trudy, Moser, Albine, Bos, Gerard M.J.

“…Supplemental Digital Content is available in the text…”
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Extended follow up of high-dose melphalan and autologous stem cell transplantation after vincristine, doxorubicin, dexamethasone induction in amyloid light chain amyloidosis of the prospective phase II HOVON-41 study by the Dutch-Belgian Co-operative Trial Group for Hematology Oncology by Hazenberg, Bouke P C, Croockewit, Alexandra, van der Holt, Bronno, Zweegman, Sonja, Bos, Gerard M J, Delforge, Michel, Raymakers, Reinier A P, Sonneveld, Pieter, Vellenga, Edo, Wijermans, Pierre W, von dem Borne, Peter A, van Oers, Marinus H, de Weerdt, Okke, Spoelstra, Fokje M, Lokhorst, Henk M

“…In a prospective multicenter phase II study, we evaluated the effect of three courses of vincristine, doxorubicin and dexamethasone followed by high-dose…”
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Phase I/II trial of weekly bortezomib with lenalidomide and dexamethasone in first relapse or primary refractory myeloma by Broijl, Annemiek, Kersten, Marie-José, Alemayehu, Wendimagegn Ghidey, Levin, Mark-David, de Weerdt, Okke, Vellenga, Edo, Meijer, Ellen, Wittebol, Shulamit, Tanis, Bea C, Cornelisse, Petra B, Stevens-Kroef, Marian, Bos, Gerard M J, Wijermans, Pierre W, Lokhorst, Henk, Sonneveld, Pieter

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Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis by den Heijer, Martin, Koster, Ted, Blom, Henk J, Bos, Gerard M.J, Briët, Ernest, Reitsma, Pieter H, Vandenbroucke, Jan P, Rosendaal, Frits R

“…Mild hyperhomocysteinemia is an established risk factor for atherosclerosis and vascular disease. 1 , 2 In classic homocystinuria, half the vascular…”
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Klebsiella pneumoniae‐triggered DC recruit human NK cells in a CCR5‐dependent manner leading to increased CCL19‐responsiveness and activation of NK cells by Van Elssen, Catharina H.M.J, Vanderlocht, Joris, Frings, Peter W.H, Senden‐Gijsbers, Birgit L.M.G, Schnijderberg, Melanie C.A, van Gelder, Michel, Meek, Bob, Libon, Christine, Ferlazzo, Guido, Germeraad, Wilfred T.V, Bos, Gerard M.J

“…Besides their role in destruction of altered self‐cells, NK cells have been shown to potentiate T‐cell responses by interacting with DC. To take advantage of…”
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OR35 by Habets, Thomas H.P.M, Molenbroeck, Stefan J.J, Frijns, Jacqueline J.Y, Bielen, Els, Voorter, Christina E.M, Bos, Gerard M.J, Redegeld, Frank A.M, Christiaans, Maarten H.L, Tilanus, Marcel G.J, Vanderlocht, Joris

“…Patients developing end stage renal disease (ESRD) are characterized by an accumulation of metabolic waste products in the blood. The majority of these waste…”
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Elimination of the chemotherapy resistant subpopulation of 4T1 mouse breast cancer by haploidentical NK cells cures the vast majority of mice by Frings, Peter W. H., Van Elssen, Catharina H. M. J., Wieten, Lotte, Matos, Catarina, Hupperets, Pierre S. J. G., Schouten, Harry C., Bos, Gerard M. J., van Gelder, Michel

“…Metastatic breast cancer is currently incurable despite initial responsiveness, assumingly due to the presence of chemoresistant subpopulations that can be…”
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Flow cytometry-based assay to evaluate human serum MUC1-Tn antibodies by Van Elssen, Catharina H.M.J., Clausen, Henrik, Germeraad, Wilfred T.V., Bennet, Eric P., Menheere, Paul P., Bos, Gerard M.J., Vanderlocht, Joris

“…Mucin-1 (MUC1) is a heavily O-glycosylated, transmembrane protein that is expressed on the apical surface of most secretory epithelia. In malignantly…”
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53-OR: HLA class I and HLA-E influence susceptibility of multiple myeloma cells to elimination by NK cells by Wieten, Lotte, van Elssen, Janine H.M.J, Sarkar, Subhashis, Groen, Richard W, Martens, Anton C.M, Bos, Gerard M.J, Tilanus, Marcel G.J

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Vitamin Supplementation Reduces Blood Homocysteine Levels: A Controlled Trial in Patients With Venous Thrombosis and Healthy Volunteers by den Heijer, Martin, Brouwer, Ingeborg A, Bos, Gerard M.J, Blom, Henk J, van der Put, Nathalie M.J, Spaans, Anja P, Rosendaal, Frits R, Thomas, Chris M.G, Haak, Hans L, Wijermans, Pierre W, Gerrits, Wim B.J

“…Hyperhomocysteinemia is a risk factor for atherosclerosis and thrombosis and is inversely related to plasma folate and vitamin B12 levels. We assessed the…”
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