Search Results - "Bos, Gerard M J"

Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy by Gong, Ying, Klein Wolterink, Roel G J, Wang, Jianxiang, Bos, Gerard M J, Germeraad, Wilfred T V

“…Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are considered as specialized immune cells that can be genetically…”
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Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial by den Heijer, Martin, Willems, Huub P.J., Blom, Henk J., Gerrits, Wim B.J., Cattaneo, Marco, Eichinger, Sabine, Rosendaal, Frits R., Bos, Gerard M.J.

“…The Vitamins and Thrombosis (VITRO) study investigated the effect of homocysteine lowering by daily supplementation of B vitamins on the risk reduction of deep…”
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Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A by Sarkar, Subhashis, van Gelder, Michel, Noort, Willy, Xu, Yunping, Rouschop, Kasper M. A., Groen, Richard, Schouten, Harry C., Tilanus, Marcel G. J., Germeraad, Wilfred T. V., Martens, Anton C. M., Bos, Gerard M. J., Wieten, Lotte

“…Immunotherapy with allogeneic natural killer (NK) cells offers therapeutic perspectives for multiple myeloma patients. Here, we aimed to refine NK cell therapy…”
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Fractionated Radiotherapy with 3 x 8 Gy Induces Systemic Anti-Tumour Responses and Abscopal Tumour Inhibition without Modulating the Humoral Anti-Tumour Response by Habets, Thomas H P M, Oth, Tammy, Houben, Ans W, Huijskens, Mirelle J A J, Senden-Gijsbers, Birgit L M G, Schnijderberg, Melanie C A, Brans, Boudewijn, Dubois, Ludwig J, Lambin, Philippe, De Saint-Hubert, Marijke, Germeraad, Wilfred T V, Tilanus, Marcel G J, Mottaghy, Felix M, Bos, Gerard M J, Vanderlocht, Joris

“…Accumulating evidence indicates that fractionated radiotherapy (RT) can result in distant non-irradiated (abscopal) tumour regression. Although preclinical…”
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No Effect of Vitamin C Administration on Neutrophil Recovery in Autologous Stem Cell Transplantation for Myeloma or Lymphoma: A Blinded, Randomized Placebo-Controlled Trial by van Gorkom, Gwendolyn N Y, Boerenkamp, Lara S, Gijsbers, Birgit L M G, van Ojik, Heidi H, Wodzig, Will K W H, Wieten, Lotte, Van Elssen, Catharina H M J, Bos, Gerard M J

“…Vitamin C is an important micronutrient for various immune cells. It increases phagocytic cell function and is necessary for T and natural killer (NK) cell…”
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The prevalence of antibodies against the HLA-DRB3 protein in kidney transplantation and the correlation with HLA expression by Habets, Thomas H P M, Hepkema, Bouke G, Kouprie, Niels, Schnijderberg, Melanie C A, van Smaalen, Tim C, Bungener, Laura B, Christiaans, Maarten H L, Bos, Gerard M J, Vanderlocht, Joris

“…Human leukocyte antigen (HLA)-DRB3 is a functional HLA class II gene, which has a limited allele diversity in the human population. Furthermore, the HLA-DRB3…”
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HOVON 104, long‐term follow‐up of bortezomib‐dexamethasone induction therapy followed by autologous stem cell transplantation in newly diagnosed AL amyloidosis patients by Minnema, Monique C., Nasserinejad, Kazem, Hegenbart, Ute, Ypma, Paula F., Wu, Ka Lung, Kersten, Marie Jose, Croockewit, Sandra, Zweegman, Sonja, Tick, Lidwine, Broijl, Annemiek, Koene, Harry, Bos, Gerard M. J., Sonneveld, Pieter, Schönland, Stefan O.

“…The HOVON 104 studied bortezomib‐dexamethasone induction therapy and autologous stem cell transplantation in 50 patients, of whom 35 received an autologous…”
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Inflammation restraining effects of prostaglandin E2 on natural killer–dendritic cell (NK-DC) interaction are imprinted during DC maturation by Van Elssen, Catharina H.M.J., Vanderlocht, Joris, Oth, Tammy, Senden-Gijsbers, Birgit L.M.G., Germeraad, Wilfred T.V., Bos, Gerard M.J.

“…Among prostaglandins (PGs), PGE2 is abundantly expressed in various malignancies and is probably one of many factors promoting tumor growth by inhibiting tumor…”
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Developing a patient portal for haematology patients requires involvement of all stakeholders and a customised design, tailored to the individual needs by Geerts, Paul A F, van der Weijden, Trudy, Loeffen, Pien G M, Janssen, Lise E F, Almekinders, Celine, Wienhold, Tobias A, Bos, Gerard M J

“…Electronic patient portals are increasingly being implemented, also in (haemato) oncology. However, portal usage is low and depends on user and provider…”
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Bortezomib Induction and Maintenance Treatment in Patients With Newly Diagnosed Multiple Myeloma: Results of the Randomized Phase III HOVON-65/ GMMG-HD4 Trial by SONNEVELD, Pieter, SCHMIDT-WOLF, Ingo G. H, WEISEL, Katja C, WITTEBOL, Shulamiet, BOS, Gerard M. J, STEVENS-KROEF, Marian, SCHEID, Christof, PFREUNDSCHUH, Michael, HOSE, Dirk, JAUCH, Anna, DER VELDE, Helgi Van, RAYMAKERS, Reinier, DER HOLT, Bronno Van, SCHAAFSMA, Martijn R, KERSTEN, Marie-Jose, MARWIJK-KOOY, Marinus Van, DUEHRSEN, Ulrich, LINDEMANN, Walter, WIJERMANS, Pierre W, LOKHORST, Henk M, GOLDSCHMIDT, Hartmut M, EL JARARI, Laila, BERTSCH, Uta, SALWENDER, Hans, ZWEEGMAN, Sonja, VELLENGA, Edo, BROYL, Annemiek, BLAU, Igor W

“…We investigated whether bortezomib during induction and maintenance improves survival in newly diagnosed multiple myeloma (MM). In all, 827 eligible patients…”
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Inhibitory receptors for HLA class I as immune checkpoints for natural killer cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy by Beelen, Nicky A., Ehlers, Femke A. I., Bos, Gerard M. J., Wieten, Lotte

“…Natural killer (NK) cells mediate potent anti-tumor responses, which makes them attractive targets for immunotherapy. The anti-tumor response of endogenous- or…”
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Exploring the potential of combining IL-2-activated NK cells with an anti-PDL1 monoclonal antibody to target multiple myeloma-associated macrophages by Ehlers, Femke A. I., Mahaweni, Niken M., van de Waterweg Berends, Annet, Saya, Thara, Bos, Gerard M. J., Wieten, Lotte

“…Multiple myeloma (MM) is an incurable disease, characterized by malignant plasma cells in the bone marrow. MM growth is largely dependent on the tumor…”
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Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells by Sarkar, Subhashis, Germeraad, Wilfred T V, Rouschop, Kasper M A, Steeghs, Elisabeth M P, van Gelder, Michel, Bos, Gerard M J, Wieten, Lotte

“…Multiple Myeloma (MM) is an incurable plasma cell malignancy residing within the bone marrow (BM). We aim to develop allogeneic Natural Killer (NK) cell…”
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Expression of tumor-associated differentiation antigens, MUC1 glycoforms and CEA, in human thymic epithelial cells : Implications for self-tolerance and tumor therapy by CLOOSEN, Silvie, ARNOLD, Janna, THIO, Marco, BOS, Gerard M. J, KYEWSKI, Bruno, GERMERAAD, Wilfred T. V

“…Expression of tissue-restricted self-antigens in the thymus, termed promiscuous gene expression, imposes T cell tolerance and protects from autoimmune…”
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HLA class I NK-epitopes and KIR diversities in patients with multiple myeloma by Beelen, Nicky A., Molenbroeck, Stefan J. J., Groeneveld, Lisette, Voorter, Christien E., Bos, Gerard M. J., Wieten, Lotte

“…Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of malignant plasma cells in the bone marrow. Myeloma cells are susceptible…”
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Elimination of the chemotherapy resistant subpopulation of 4T1 mouse breast cancer by haploidentical NK cells cures the vast majority of mice by Frings, Peter W. H., Van Elssen, Catharina H. M. J., Wieten, Lotte, Matos, Catarina, Hupperets, Pierre S. J. G., Schouten, Harry C., Bos, Gerard M. J., van Gelder, Michel

“…Metastatic breast cancer is currently incurable despite initial responsiveness, assumingly due to the presence of chemoresistant subpopulations that can be…”
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The Effect of Vitamin C (Ascorbic Acid) in the Treatment of Patients with Cancer: A Systematic Review by van Gorkom, Gwendolyn N Y, Lookermans, Eline L, Van Elssen, Catharina H M J, Bos, Gerard M J

“…Many cancer patients on intensive chemotherapy lack vitamin C. Vitamin C stimulates the production and activation of immune cells, so perhaps supplementation…”
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Antibody-dependent cellular cytotoxicity-inducing antibodies enhance the natural killer cell anti-cancer response against patient-derived pancreatic cancer organoids by Beelen, Nicky A, Aberle, Merel R, Bruno, Virginia, Olde Damink, Steven W M, Bos, Gerard M J, Rensen, Sander S, Wieten, Lotte

“…Pancreatic cancer is associated with poor prognosis, and limited treatment options are available for the majority of patients. Natural killer (NK) cells in…”
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Tuning Natural Killer Cell Anti-multiple Myeloma Reactivity by Targeting Inhibitory Signaling via KIR and NKG2A by Mahaweni, Niken M, Ehlers, Femke A I, Bos, Gerard M J, Wieten, Lotte

“…Natural killer (NK) cells are attractive candidates for allogeneic cell-based immunotherapy due to their potent antitumor effector function and good safety…”
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Klebsiella pneumoniae‐triggered DC recruit human NK cells in a CCR5‐dependent manner leading to increased CCL19‐responsiveness and activation of NK cells by Van Elssen, Catharina H.M.J, Vanderlocht, Joris, Frings, Peter W.H, Senden‐Gijsbers, Birgit L.M.G, Schnijderberg, Melanie C.A, van Gelder, Michel, Meek, Bob, Libon, Christine, Ferlazzo, Guido, Germeraad, Wilfred T.V, Bos, Gerard M.J

“…Besides their role in destruction of altered self‐cells, NK cells have been shown to potentiate T‐cell responses by interacting with DC. To take advantage of…”
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