Search Results - "Bortz, D."

The medial septum enhances reversal learning via opposing actions on ventral tegmental area and substantia nigra dopamine neurons by Bortz, D M, Gazo, K L, Grace, A A

“…Cognitive flexibility deficits are one of the most pervasive symptoms across psychiatric disorders, making continued investigation of the circuitry underlying…”
Get full text

INVESTIGATION OF A STRUCTURED FISHER'S EQUATION WITH APPLICATIONS IN BIOCHEMISTRY by NARDINI, JOHN T., BORTZ, D. M.

“…Recent biological research has sought to understand how biochemical signaling pathways, such as the mitogen-activated protein kinase (MAPK) family, influence…”
Get full text

Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortex by Bortz, D.M., Wu, H.-Q., Schwarcz, R., Bruno, J.P.

“…Cognitive deficits represent core symptoms in schizophrenia (SZ) and predict patient outcome; however, they remain poorly treated by current antipsychotic…”
Get full text

Chromatin immunoprecipitation (ChIP): revisiting the efficacy of sample preparation, sonication, quantification of sheared DNA, and analysis via PCR by Schoppee Bortz, Pamela D, Wamhoff, Brian R

“…The "quantitative" ChIP, a tool commonly used to study protein-DNA interactions in cells and tissue, is a difficult assay often plagued with technical error…”
Get full text

Choline Supplementation Does Not Promote Atherosclerosis in CETP-Expressing Male Apolipoprotein E Knockout Mice by Collins, Heidi L, Adelman, Steven J, Butteiger, Dustie N, Bortz, Jonathan D

“…Dietary trimethylamines, such as choline, metabolized by intestinal microbiota to trimethylamine are absorbed by the gut and oxidized to trimethylamine N-oxide…”
Get full text

Localized infusions of the partial alpha 7 nicotinic receptor agonist SSR180711 evoke rapid and transient increases in prefrontal glutamate release by Bortz, D.M, Mikkelsen, J.D, Bruno, J.P

“…Highlights • SSR180711 led to dose-dependent increases in prefrontal glutamate levels. • SSR180711-stimulated glutamate release via α7 nicotinic receptors. •…”
Get full text

Pattern Formation in the Longevity-Related Expression of Heat Shock Protein-16.2 in Caenorhabditis elegans by Wentz, J. M., Mendenhall, A. R., Bortz, D. M.

“…Aging in Caenorhabditis elegans is controlled, in part, by the insulin-like signaling and heat shock response pathways. Following thermal stress, expression…”
Get full text

Influence of Initial Conditions on Data-Driven Model Identification for Ideal MHD Test Problems by Vasey, G., O'Shea, B., Christlieb, A., Messenger, D., Bortz, D.

“…Data-driven methods of model identification are able to discern governing dynamics of a system from data. To ensure fidelity in the models data-driven methods…”
Get full text

Molecular Mechanisms of Collagen Isotype-Specific Modulation of Smooth Muscle Cell Phenotype by Orr, A Wayne, Lee, Monica Y, Lemmon, Julia A, Yurdagul, Arif, Gomez, Maria F, Bortz, Pamela D. Schoppee, Wamhoff, Brian R

“…OBJECTIVE—Smooth muscle cell (SMC) phenotypic modulation, an important component of atherosclerosis progression, is critically regulated by the matrix, with…”
Get full text

Determination of personalized diabetes treatment plans using a two-delay model by Kissler, S.M., Cichowitz, C., Sankaranarayanan, S., Bortz, D.M.

“…Diabetes cases worldwide have risen steadily over the past few decades, lending urgency to the search for more efficient, effective, and personalized ways to…”
Get full text

Fracture toughness and creep performance of PMMA composites containing micro and nanosized carbon filaments by Varela-Rizo, H., Weisenberger, M., Bortz, D.R., Martin-Gullon, I.

“…Chopped carbon fiber (CCF), multiwall carbon nanotubes (MWCNTs) and carbon nanofibers (CNFs) were introduced to polymethylmethacrylate (PMMA) via melt…”
Get full text

Sensitivity analysis of a nonlinear lumped parameter model of HIV infection dynamics by Bortz, D.M, Nelson, P.W

“…A formal sensitivity analysis is performed on a delay differential equation model for the viral dynamics of an in vivo HIV infection during protease inhibitor…”
Get full text

Nuclear Factor of Activated T Cells 5 Regulates Vascular Smooth Muscle Cell Phenotypic Modulation by Halterman, Julia A, Kwon, H Moo, Zargham, Ramin, Bortz, Pamela D Schoppee, Wamhoff, Brian R

“…OBJECTIVE—The tonicity-responsive transcription factor, nuclear factor of activated T cells 5 (NFAT5/tonicity enhancer binding protein [TonEBP]), has been well…”
Get full text

Determining equilibrium osmolarity in poly(ethylene glycol)/chondrotin sulfate gels mimicking articular cartilage by Sircar, S., Aisenbrey, E., Bryant, S.J., Bortz, D.M.

“…We present an experimentally guided, multi-phase, multi-species polyelectrolyte gel model to make qualitative predictions on the equilibrium electro-chemical…”
Get full text

Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats by Bortz, D.M., Upton, B.A., Mikkelsen, J.D., Bruno, J.P.

“…Positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (α7nAChRs) exhibit pro-cognitive effects in animal models of schizophrenia and…”
Get full text

Hemodynamic Activation of β-Catenin and T-Cell-Specific Transcription Factor Signaling in Vascular Endothelium Regulates Fibronectin Expression by Gelfand, Bradley D, Meller, Julia, Pryor, Andrew W, Kahn, Michael, Bortz, Pamela D Schoppee, Wamhoff, Brian R, Blackman, Brett R

“…OBJECTIVE—The goal of this study was to assess the activity of β-catenin/T-cell-specific transcription factor (TCF) signaling in atherosclerosis development…”
Get full text

Cyclosporine up-regulates Krüppel-like factor-4 (KLF4) in vascular smooth muscle cells and drives phenotypic modulation in vivo by Garvey, Sean M, Sinden, Daniel S, Schoppee Bortz, Pamela D, Wamhoff, Brian R

“…Cyclosporine A (CSA, calcineurin inhibitor) has been shown to block both vascular smooth muscle cell (VSMC) proliferation in cell culture and vessel neointimal…”
Get more information

Estimating kinetic parameters from HIV primary infection data through the eyes of three different mathematical models by Ciupe, M.S., Bivort, B.L., Bortz, D.M., Nelson, P.W.

“…The dynamics of HIV-1 infection consist of three distinct phases starting with primary infection, then latency and finally AIDS or drug therapy. In this paper…”
Get full text

The Host Response to Line Sepsis: Experimental and Computational Analysis of Complement Activation against Coagulase-Negative Staphylococcal Biofilms by Conrad, E, Satorius, A, Sharma, P, Bortz, D, Younger, J

Get full text

Transient inactivation of the ventral hippocampus in neonatal rats impairs the mesolimbic regulation of prefrontal glutamate release in adulthood by Bortz, D.M., Jørgensen, C.V., Mikkelsen, J.D., Bruno, J.P.

“…Cognitive deficits in schizophrenia (SZ) reflect maturational disruptions within a neural system that includes the ventral hippocampus (VH), nucleus accumbens…”
Get full text