Search Results - "Bortolozzi, Analía"

Serotonin 5-HT1A Receptors as Targets for Agents to Treat Psychiatric Disorders: Rationale and Current Status of Research by Celada, Pau, Bortolozzi, Analía, Artigas, Francesc

“…Psychiatric disorders represent a large economic burden in modern societies. However, pharmacological treatments are still far from optimal. Drugs used in the…”
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Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis by Carballo-Carbajal, Iria, Laguna, Ariadna, Romero-Giménez, Jordi, Cuadros, Thais, Bové, Jordi, Martinez-Vicente, Marta, Parent, Annabelle, Gonzalez-Sepulveda, Marta, Peñuelas, Núria, Torra, Albert, Rodríguez-Galván, Beatriz, Ballabio, Andrea, Hasegawa, Takafumi, Bortolozzi, Analía, Gelpi, Ellen, Vila, Miquel

“…In Parkinson’s disease (PD) there is a selective degeneration of neuromelanin-containing neurons, especially substantia nigra dopaminergic neurons. In humans,…”
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Overexpression of TFEB Drives a Pleiotropic Neurotrophic Effect and Prevents Parkinson’s Disease-Related Neurodegeneration by Torra, Albert, Parent, Annabelle, Cuadros, Thais, Rodríguez-Galván, Beatriz, Ruiz-Bronchal, Esther, Ballabio, Andrea, Bortolozzi, Analía, Vila, Miquel, Bové, Jordi

“…The possible implication of transcription factor EB (TFEB) as a therapeutic target in Parkinson’s disease has gained momentum since it was discovered that TFEB…”
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In vivo knockdown of astroglial glutamate transporters GLT-1 and GLAST increases excitatory neurotransmission in mouse infralimbic cortex: Relevance for depressive-like phenotypes by Fullana, Mª Neus, Covelo, Ana, Bortolozzi, Analía, Araque, Alfonso, Artigas, Francesc

“…Alterations of energy metabolism and of astrocyte number/function in ventral anterior cingulate cortex (vACC) have been reported in major depressive disorder…”
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Expression of Serotonin1A and Serotonin2A Receptors in Pyramidal and GABAergic Neurons of the Rat Prefrontal Cortex by Santana, Noemí, Bortolozzi, Analía, Serrats, Jordi, Mengod, Guadalupe, Artigas, Francesc

“…Serotonergic 5-HT1A and 5-HT2A receptors are abundantly expressed in prefrontal cortex (PFC) and are targets of atypical antipsychotic drugs. They mediate,…”
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mTOR Knockdown in the Infralimbic Cortex Evokes A Depressive-like State in Mouse by Garro-Martínez, Emilio, Fullana, Maria Neus, Florensa-Zanuy, Eva, Senserrich, Julia, Paz, Verónica, Ruiz-Bronchal, Esther, Adell, Albert, Castro, Elena, Díaz, Álvaro, Pazos, Ángel, Bortolozzi, Analía, Pilar-Cuéllar, Fuencisla

“…Fast and sustained antidepressant effects of ketamine identified the mammalian target of rapamycin (mTOR) signaling pathway as the main modulator of its…”
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Selective enhacement of mesocortical dopaminergic transmission by noradrenergic drugs: therapeutic opportunities in schizophrenia by Masana, Mercè, Bortolozzi, Analía, Artigas, Francesc

“…The superior efficacy of atypical vs. classical antipsychotic drugs to treat negative symptoms and cognitive deficits in schizophrenia appears related to their…”
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Lenti‐GDNF Gene Therapy Protects Against Alzheimer's Disease‐Like Neuropathology in 3xTg‐AD Mice and MC65 Cells by Revilla, Susana, Ursulet, Suzanna, Álvarez‐López, María Jesús, Castro‐Freire, Marco, Perpiñá, Unai, García‐Mesa, Yoelvis, Bortolozzi, Analía, Giménez‐Llort, Lydia, Kaliman, Perla, Cristòfol, Rosa, Sarkis, Chamsy, Sanfeliu, Coral

“…Summary Aims Glial cell‐derived neurotrophic factor (GDNF) is emerging as a potent neurotrophic factor with therapeutic potential against a range of…”
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The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity by Bortolozzi, Analía, Díaz‐Mataix, Llorenç, Scorza, M. Cecilia, Celada, Pau, Artigas, Francesc

“…Atypical antipsychotics show preferential 5‐HT2A versus dopamine (DA) D2 receptor affinity. At clinical doses, they fully occupy cortical 5‐HT2 receptors,…”
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Dopamine neurotransmission and atypical antipsychotics in prefrontal cortex: a critical review by Masana, Mercè, Santana, Noemí, Artigas, Francesc, Bortolozzi, Analía

“…Schizophrenia has been historically characterized by the presence of positive symptomatology, however, decades of research highlight the importance of…”
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Acute 5-HT1A autoreceptor knockdown increases antidepressant responses and serotonin release in stressful conditions by Ferrés-Coy, Albert, Santana, Noemí, Castañé, Anna, Cortés, Roser, Carmona, María C., Toth, Miklos, Montefeltro, Andrés, Artigas, Francesc, Bortolozzi, Analía

“…Rationale Identifying the etiological factors in anxiety and depression is critical to develop more efficacious therapies. The inhibitory serotonin 1A…”
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Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis by Schneeberger, Marc, Gómez-Valadés, Alicia G., Altirriba, Jordi, Sebastián, David, Ramírez, Sara, Garcia, Ainhoa, Esteban, Yaiza, Drougard, Anne, Ferrés-Coy, Albert, Bortolozzi, Analía, Garcia-Roves, Pablo M., Jones, John G., Manadas, Bruno, Zorzano, Antonio, Gomis, Ramon, Claret, Marc

“…Alterations in ER homeostasis have been implicated in the pathophysiology of obesity and type-2 diabetes (T2D). Acute ER stress induction in the hypothalamus…”
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Lipid nanoparticles for antisense oligonucleotide gene interference into brain border-associated macrophages by Calero, Macarena, Moleiro, Lara H., Sayd, Aline, Dorca, Yeray, Miquel-Rio, Lluis, Paz, Verónica, Robledo-Montaña, Javier, Enciso, Eduardo, Acción, Fernando, Herráez-Aguilar, Diego, Hellweg, Thomas, Sánchez, Luis, Bortolozzi, Analía, Leza, Juan C., García-Bueno, Borja, Monroy, Francisco

“…A colloidal synthesis’ proof-of-concept based on the Bligh–Dyer emulsion inversion method was designed for integrating into lipid nanoparticles (LNPs)…”
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Strategies for producing faster acting antidepressants by Adell, Albert, Castro, Elena, Celada, Pau, Bortolozzi, Analéa, Pazos, Angel, Artigas, Francesc

“…The global impact of depression is growing but there have been no substantial advances to overcome two main problems of its treatment: slowness and limited…”
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Functional Rescue of Dopaminergic Neuron Loss in Parkinson's Disease Mice After Transplantation of Hematopoietic Stem and Progenitor Cells by Altarche-Xifro, Wassim, di Vicino, Umberto, Muñoz-Martin, Maria Isabel, Bortolozzi, Analía, Bové, Jordi, Vila, Miquel, Cosma, Maria Pia

“…Parkinson's disease is a common neurodegenerative disorder, which is due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and…”
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A Functional Leptin System Is Essential for Sodium Tungstate Antiobesity Action by Canals, Ignasi, Carmona, María C, Amigó, Marta, Barbera, Albert, Bortolozzi, Analía, Artigas, Francesc, Gomis, Ramon

“…Sodium tungstate is a novel agent in the treatment of obesity. In diet-induced obese rats, it is able to reduce body weight gain by increasing energy…”
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Can we increase speed and efficacy of antidepressant treatments? Part I: General aspects and monoamine-based strategies by Artigas, Francesc, Bortolozzi, Analia, Celada, Pau

“…Major depressive disorder (MDD) is a severe psychiatric syndrome with high prevalence and socioeconomic impact. Current antidepressant treatments are based on…”
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In vivo efflux of serotonin in the dorsal raphe nucleus of 5‐HT1A receptor knockout mice by Bortolozzi, Analía, Amargós‐Bosch, Mercè, Toth, Miklos, Artigas, Francesc, Adell, Albert

“…In the dorsal raphe nucleus (DR), extracellular serotonin (5‐HT) regulates serotonergic transmission through 5‐HT1A autoreceptors. In this work we used in vivo…”
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Astrocyte control of glutamatergic activity: Downstream effects on serotonergic function and emotional behavior by Fullana, Neus, Gasull-Camós, Júlia, Tarrés-Gatius, Mireia, Castañé, Anna, Bortolozzi, Analía, Artigas, Francesc

“…Major depressive disorder (MDD) is a leading cause of disability worldwide, with a poorly known pathophysiology and sub-optimal treatment, based on serotonin…”
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Increased Expression of Alpha-, Beta-, and Gamma-Synucleins in Brainstem Regions of a Non-Human Primate Model of Parkinson’s Disease by Duperrier, Sandra, Bortolozzi, Analia, Sgambato, Véronique

“…Parkinson’s disease (PD) is characterized by cell loss in the substantia nigra and the presence of alpha-synuclein (α-syn)-containing neuronal Lewy bodies…”
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