Search Results - "Borsook, D."

Reward deficiency and anti-reward in pain chronification by Borsook, D, Linnman, C, Faria, V, Strassman, A M, Becerra, L, Elman, I

“…Converging lines of evidence suggest that the pathophysiology of pain is mediated to a substantial degree via allostatic neuroadaptations in reward- and…”
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Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans by Becerra, L, Navratilova, E, Porreca, F, Borsook, D

“…In humans, functional magnetic resonance imaging (fMRI) activity in the anterior cingulate cortex (ACC) and the nucleus accumbens (NAc) appears to reflect…”
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The enigma of the dorsolateral pons as a migraine generator by Borsook, D, Burstein, R

“…In this editorial, we integrate improved understanding of functional and structural brain stem anatomy with lessons learned from other disciplines on brainstem…”
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The brain and behavioral correlates of motor-related analgesia (MRA) by Holmes, S.A., Kim, A., Borsook, D.

“…The human motor system has the capacity to act as an internal form of analgesia. Since the discovery of the potential influence of motor systems on analgesia…”
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Sex and the migraine brain by Borsook, D, Erpelding, N, Lebel, A, Linnman, C, Veggeberg, R, Grant, P.E, Buettner, C, Becerra, L, Burstein, R

“…Abstract The brain responds differently to environmental and internal signals that relate to the stage of development of neural systems. While genetic and…”
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Migraine changes the brain: neuroimaging makes its mark by Sprenger, Till, Borsook, David

“…This review summarizes key findings of the current literature on functional neuroimaging in migraine and describes how these studies have changed our view of…”
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Unmasking the mysteries of the habenula in pain and analgesia by Shelton, L, Becerra, L, Borsook, D

“…The habenula is a small bilateral structure in the posterior-medial aspect of the dorsal thalamus that has been implicated in a remarkably wide range of…”
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Preclinical assessment of candidate analgesic drugs: recent advances and future challenges by Negus, S S, Vanderah, T W, Brandt, M R, Bilsky, E J, Becerra, L, Borsook, D

“…In analgesic drug development, preclinical procedures are widely used to assess drug effects on pain-related behaviors. These procedures share two principal…”
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The role of imaging by Borsook, D

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Painful heat reveals hyperexcitability of the temporal pole in interictal and ictal migraine States by Moulton, E A, Becerra, L, Maleki, N, Pendse, G, Tully, S, Hargreaves, R, Burstein, R, Borsook, D

“…During migraine attacks, alterations in sensation accompanying headache may manifest as allodynia and enhanced sensitivity to light, sound, and odors. Our…”
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Mapping pain activation and connectivity of the human habenula by Shelton, L, Pendse, G, Maleki, N, Moulton, E A, Lebel, A, Becerra, L, Borsook, D

“…The habenula, located in the posterior thalamus, is implicated in a wide array of functions. Animal anatomical studies have indicated that the structure…”
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Use of functional imaging across clinical phases in CNS drug development by Borsook, D, Becerra, L, Fava, M

“…The use of novel brain biomarkers using nuclear magnetic resonance imaging holds potential of making central nervous system (CNS) drug development more…”
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The responsive amygdala: Treatment-induced alterations in functional connectivity in pediatric complex regional pain syndrome by Simons, L.E., Pielech, M., Erpelding, N., Linnman, C., Moulton, E., Sava, S., Lebel, A., Serrano, P., Sethna, N., Berde, C., Becerra, L., Borsook, D.

“…Amygdala connectivity is altered in children with chronic neuropathic pain and is responsive to intensive interdisciplinary treatment, with an associated…”
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Pain and motor system plasticity by Borsook, D.

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Alterations in brain structure and functional connectivity in prescription opioid-dependent patients by Upadhyay, Jaymin, Maleki, Nasim, Potter, Jennifer, Elman, Igor, Rudrauf, David, Knudsen, Jaime, Wallin, Diana, Pendse, Gautam, McDonald, Leah, Griffin, Margaret, Anderson, Julie, Nutile, Lauren, Renshaw, Perry, Weiss, Roger, Becerra, Lino, Borsook, David

“…A dramatic increase in the use and dependence of prescription opioids has occurred within the last 10 years. The consequences of long-term prescription opioid…”
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Triptans disrupt brain networks and promote stress-induced CSD-like responses in cortical and subcortical areas by Becerra, L, Bishop, J, Barmettler, G, Xie, Y, Navratilova, E, Porreca, F, Borsook, D

“…A number of drugs, including triptans, promote migraine chronification in susceptible individuals. In rats, a period of triptan administration over 7 days can…”
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An fMRI case report of photophobia: Activation of the trigeminal nociceptive pathway by Moulton, E.A., Becerra, L., Borsook, D.

“…Photophobia, or painful oversensitivity to light, occurs in a number of clinical conditions, which range from superficial eye irritation to meningitis. In this…”
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Basal ganglia dysfunction in complex regional pain syndrome – A valid hypothesis? by Azqueta‐Gavaldon, M., Schulte‐Göcking, H., Storz, C., Azad, S., Reiners, A., Borsook, D., Becerra, L., Kraft, E.

“…Complex regional pain syndrome (CRPS) is a poorly understood pain disorder of the limbs. Maladaptive cortical plasticity has been shown to play a major role in…”
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fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children by Lebel, A., Becerra, L., Wallin, D., Moulton, E. A., Morris, S., Pendse, G., Jasciewicz, J., Stein, M., Aiello-Lammens, M., Grant, E., Berde, C., Borsook, D.

“…Complex regional pain syndrome (CRPS) in paediatric patients is clinically distinct from the adult condition in which there is often complete resolution of its…”
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CNS activation maps in awake rats exposed to thermal stimuli to the dorsum of the hindpaw by Becerra, L., Chang, P.C., Bishop, J., Borsook, D.

“…Imaging pain pathways in rats offers a tool to investigate CNS systems in acute and chronic rodent models of pain, neural plasticity associated with the…”
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