Search Results - "Borris, R. P"

Differential Regulation of Calcium Signalling Pathways by Components of Piper methysticum ('Awa) by Shimoda, L. M. N, Showman, A, Baker, J. D, Lange, I, Koomoa, D. L, Stokes, A. J, Borris, R. P, Turner, H

“…Kava is a soporific, anxiolytic and relaxant in widespread ritual and recreational use throughout the Pacific. Traditional uses of kava by indigenous Pacific…”
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Natural products research: perspectives from a major pharmaceutical company by Borris, Robert P.

“…Natural products research continues to provide a tremendous variety of lead structures which are used as templates for the development of new drugs by the…”
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Diterpenoid, Steroid, and Triterpenoid Agonists of Liver X Receptors from Diversified Terrestrial Plants and Marine Sources by Jayasuriya, Hiranthi, Herath, Kithsiri B, Ondeyka, John G, Guan, Ziqiang, Borris, Robert P, Tiwari, Suroojnauth, de Jong, Wil, Chavez, Flor, Moss, Jeremy, Stevenson, Dennis W, Beck, Hans T, Slattery, Marc, Zamora, Nelson, Schulman, Marvin, Ali, Aisha, Sharma, Neelam, MacNaul, Karen, Hayes, Nancy, Menke, John G, Singh, Sheo B

“…It has been demonstrated that liver X receptors (LXR) play a significant role in cholesterol homeostasis. Agonists of LXR are expected to increase cellular…”
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Natural Product Drug Discovery and Development: New Perspectives on International Collaboration by Baker, Joseph T, Borris, Robert P, Carté, Brad, Cordell, Geoffrey A, Soejarto, Djaja D, Cragg, Gordon M, Gupta, Mahabir P, Iwu, Maurice M, Madulid, Domingo R, Tyler, Varro E

“…Until recently, the prevailing attitude in developed nations regarded the world's genetic resources, which are mainly concentrated in the developing world, as…”
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L-741,494, a Fungal Metabolite That Is an Inhibitor of Interleukin-1β Converting Enzyme by Salvatore, Michael J, Hensens, Otto D, Zink, Deborah L, Liesch, Jerrold, Dufresne, Claude, Ondeyka, John G, Jürgens, Tannis M, Borris, Robert P, Raghoobar, Susan, McCauley, Ermenegilda, Kong, Lin, Gartner, Suzanne E, Koch, Gregory E, Pelaéz, Fernando, Diez, Maria Teresa, Cascales, Carmen, Martin, Isabel, Polishook, Jon D, Balick, Michael J, Beck, Hans T, King, Steven R, Hsu, Amy, Lingham, Russell B

“…gamma-Pyrone-3-acetic acid (L-741,494) is a novel metabolite produced by a culture of the fungal genus Xylaria. This substance is a water-soluble, competitive,…”
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Novel Nematocidal Agents from Curcuma comosa by Jurgens, Tannis M, Frazier, Easter G, Schaeffer, James M, Jones, Tracey E, Zink, Deborah L, Borris, Robert P, Nanakorn, Weerachai, Beck, Hans T, Balick, Michael J

“…Curcuma comosa is a member of the economically important plant family, Zingiberaceae. A methanolic extract of C. comosa was shown to be nematocidal when tested…”
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Ethnopharmacologic and phytochemical studies of the Thymelaeaceae by Borris, R P, Blaskó, G, Cordell, G A

“…The ethnobotany, ethnopharmacology and phytochemistry of the Thymelaeaceae are reviewed. Some members of this family find wide use commercially whilst others…”
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Studies of the Thymelaeaceae II. Antineoplastic Principles of Gnidia kraussiana by Borris, Robert P, Cordell, Geoffrey A

“…The acetone and methanol extracts of Gnidia kraussiana roots displayed activity against the P-388 lymphocytic leukemia. Bioactivity-directed fractionation led…”
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L-156,602, a C5a antagonist with a novel cyclic hexadepsipeptide structure from Streptomyces sp. MA6348. Fermentation, isolation and structure determination by Hensens, O D, Borris, R P, Koupal, L R, Caldwell, C G, Currie, S A, Haidri, A A, Homnick, C F, Honeycutt, S S, Lindenmayer, S M, Schwartz, C D

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NMR Spectral Analysis of Cadambine from Anthocephalus chinensis by Handa, Sukhdev S, Borris, Robert P, Cordell, Geoffrey A, Phillipson, J. David

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Isolation and Structure of Antagonists of Chemokine Receptor (CCR5) by Jayasuriya, H, Herath, K B, Ondeyka, J G, Polishook, J D, Bills, G F, Dombrowski, A W, Springer, MS, Siciliano, S, Malkowitz, L, Sanchez, M, Guan, Z, Tiwari, S, Stevenson, D W, Borris, R P, Singh, S B

“…Human CCR5 is a G-coupled receptor that binds to the envelope protein gp120 and CD4 and mediates the HIV-1 viral entry into the cells. The blockade of this…”
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Isolation and Structure of Antagonists of Chemokine Receptor (CCR5) by Jayasuriya, Hiranthi, Herath, Kithsiri B, Ondeyka, John G, Polishook, Jon D, Bills, Gerald F, Dombrowski, Anne W, Springer, Marty S, Siciliano, Sal, Malkowitz, Lorraine, Sanchez, Manuel, Guan, Ziqiang, Tiwari, Suroojnauth, Stevenson, Dennis W, Borris, Robert P, Singh, Sheo B

“…Human CCR5 is a G-coupled receptor that binds to the envelope protein gp120 and CD4 and mediates the HIV-1 viral entry into the cells. The blockade of this…”
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Guttiferone I, a New Prenylated Benzophenone from Garcinia humilis as a Liver X Receptor Ligand by Herath, Kithsiri, Jayasuriya, Hiranthi, Ondeyka, John G, Guan, Ziqiang, Borris, Robert P, Stijfhoorn, Eirik, Stevenson, Dennis, Wang, Jianhua, Sharma, Neelam, MacNaul, Karen, Menke, John G, Ali, Aisha, Schulman, Marvin J, Singh, Sheo B

“…Liver X receptors (LXR) have been implicated in cholesterol homeostasis. Agonists of LXR are expected to increase cholesterol efflux, lower LDL, and raise HDL…”
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Natural products research : perspectives from a major pharmaceutical company. Discussion by BORRIS, R. P

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Rediocides B−E, Potent Insecticides from Trigonostemon reidioides by Jayasuriya, Hiranthi, Zink, Deborah L, Borris, Robert P, Nanakorn, Weerachai, Beck, Hans T, Balick, Michael J, Goetz, Michael A, Gregory, Lynn, Shoop, Wesley L, Singh, Sheo B

“…Four new congeners, rediocides B−E (2−5), of the previously reported rediocide A (1) were isolated from a methanol extract of the roots of the plant…”
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Structure and Stereochemistry of Rediocide A, A Highly Modified Daphnane from Trigonostemon reidioides Exhibiting Potent Insecticidal Activity by Jayasuriya, Hiranthi, Zink, Deborah L, Singh, Suresh B, Borris, Robert P, Nanakorn, Weerachai, Beck, Hans T, Balick, Michael J, Goetz, Michael A, Slayton, Lyndia, Gregory, Lynn, Zakson-Aiken, Michelle, Shoop, Wesley, Singh, Sheo B

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SEPARATION OF CRUDE PLANT EXTRACTS WITH HIGH SPEED CCC FOR PRIMARY SCREENING IN DRUG DISCOVERY by Armbruster, Jean A., Borris, Robert P., Jimenez, Quirico, Zamora, Nelson, Tamayo-Castillo, Giselle, Harris, Guy H.

“…High speed countercurrent chromatography (HSCCC) was used in a pre-fractionation pilot study to improve the quality of crude plant samples for primary…”
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Microminutin, a novel cytotoxic coumarin from Micromelum minutum (Rutaceae) by Tantivatana, Payom, Ruangrungsi, Nijsiri, Vaisiriroj, V, Lankin, David C, Bhacca, Norman S, Borris, Robert P, Cordell, Geoffrey A, Johnson, LeRoy F

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Interactions with Source Countries. Guidelines for Members of the American Society of Pharmacognosy by Cragg, Gordon M, Baker, Joseph T, Borris, Robert P, Carte, Brad, Cordell, Geoffrey A, Soejarto, Djaja D, Gupta, Mahabir P, Iwu, Maurice M, Madulid, Domingo A

“…The formulation of a set of guidelines for members of the American Society of Pharmacognosy to follow in their relationship with genetically rich source…”
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Chemistry of Acronycine I. Carbon- 13 NMR Studies of Acronycine and Related Compounds by Funayama, Shinji, Borris, Robert P, Cordell, Geoffrey A

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