Search Results - "Borrello, María Teresa"

Evidencing a Pancreatic Ductal Adenocarcinoma Subpopulation Sensitive to the Proteasome Inhibitor Carfilzomib by Fraunhoffer, Nicolas A, Abuelafia, Analía Meilerman, Bigonnet, Martin, Gayet, Odile, Roques, Julie, Telle, Emmanuel, Santofimia-Castaño, Patricia, Borrello, María Teresa, Chuluyan, Eduardo, Dusetti, Nelson, Iovanna, Juan

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a survival rate less than 5%. Multiple chemotherapeutic drugs have been tested to improve…”
Get full text

NUPR1 protects liver from lipotoxic injury by improving the endoplasmic reticulum stress response by Teresa Borrello, Maria, Rita Emma, Maria, Listi, Angela, Rubis, Marion, Coslet, Sergiu, Augello, Giuseppa, Cusimano, Antonella, Cabibi, Daniela, Porcasi, Rossana, Giannitrapani, Lydia, Soresi, Maurizio, Pantuso, Gianni, Blyth, Karen, Montalto, Giuseppe, Pin, Christopher, Cervello, Melchiorre, Iovanna, Juan

“…Non‐alcoholic fatty liver (NAFL) and related syndromes affect one‐third of the adult population in industrialized and developing countries. Lifestyle and…”
Get full text

Synthesis of Carboxamide‐Containing Tranylcypromine Analogues as LSD1 (KDM1A) Inhibitors Targeting Acute Myeloid Leukemia by Teresa Borrello, Maria, Benelkebir, Hanae, Lee, Adam, Hin Tam, Chak, Shafat, Manar, Rushworth, Stuart A., Bowles, Kristian M., Douglas, Leon, Duriez, Patrick J., Bailey, Sarah, Crabb, Simon J., Packham, Graham, Ganesan, A.

“…Lysine‐specific demethylase 1 (LSD1/KDM1A) oxidatively removes methyl groups from histone proteins, and its aberrant activity has been correlated with cancers…”
Get full text

Traditional Knowledge Evolution over Half of a Century: Local Herbal Resources and Their Changes in the Upper Susa Valley of Northwest Italy by Sulaiman, Naji, Zocchi, Dauro M, Borrello, Maria Teresa, Mattalia, Giulia, Antoniazzi, Luca, Berlinghof, S Elisabeth, Bewick, Amber, Häfliger, Ivo, Schembs, Mia, Torri, Luisa, Pieroni, Andrea

“…Susa Valley, located in the Italian Western Alps, has served as a meeting point for cultural, spiritual, and commercial exchange for a long period of history…”
Get full text

Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin by Robertson, James C, Hurley, Nate C, Tortorici, Marcello, Ciossani, Giuseppe, Borrello, Maria Teresa, Vellore, Nadeem A, Ganesan, A, Mattevi, Andrea, Baron, Riccardo

“…Lysine specific demethylase-1 (LSD1/KDM1A) in complex with its corepressor protein CoREST is a promising target for epigenetic drugs. No therapeutic that…”
Get full text

Chronic liver diseases: From development to novel pharmacological therapies: IUPHAR Review 37 by Borrello, Maria Teresa, Mann, Derek

“…Chronic liver diseases comprise a broad spectrum of burdensome diseases that still lack effective pharmacological therapies. Our research group focuses on…”
Get full text

WED-232 - Discovery of novel small molecule inhibitors of HDAC6 that suppress liver fibrosis by Borrello, Maria Teresa, Ruzic, Dusan, Oakley, Fiona, Nikolic, Katarina, Mann, Jelena, Mann, Derek

Get full text

Discovery of novel small molecule inhibitors of HDAC6 that suppress liver fibrosis by Borrello, Maria Teresa, Ruzic, Dusan, Oakley, Fiona, Nikolic, Katarina, Mann, Jelena, Mann, Derek

Get full text

NUPR1 interacts with eIF2α and is required for resolution of the ER stress response in pancreatic tissue by Borrello, Maria Teresa, Santofimia‐Castaño, Patricia, Bocchio, Marco, Listi, Angela, Fraunhoffer, Nicolas, Soubeyran, Philippe, Chevet, Eric, Pin, Christopher, Iovanna, Juan

“…Nuclear protein 1 (NUPR1) is a stress response protein overexpressed upon cell injury in virtually all organs including the exocrine pancreas. Despite NUPR1's…”
Get full text

Loss of activating transcription factor 3 prevents KRAS-mediated pancreatic cancer by Azizi, Nawab, Toma, Jelena, Martin, Mickenzie, Khalid, Muhammad Faran, Mousavi, Fatemeh, Win, Phyo Wei, Borrello, Maria Teresa, Steele, Nina, Shi, Jiaqi, di Magliano, Marina Pasca, Pin, Christopher L.

“…The unfolded protein response (UPR) is activated in pancreatic pathologies and suggested as a target for therapeutic intervention. In this study, we examined…”
Get full text

cis‐cyclopropylamines as mechanism‐based inhibitors of monoamine oxidases by Malcomson, Thomas, Yelekci, Kemal, Borrello, Maria Teresa, Ganesan, A, Semina, Elena, De Kimpe, Norbert, Mangelinckx, Sven, Ramsay, Rona R

“…Cyclopropylamines, inhibitors of monoamine oxidases (MAO) and lysine‐specific demethylase (LSD1), provide a useful structural scaffold for the design of…”
Get full text

Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A) by Borrello, Maria Teresa, Schinor, Benjamin, Bartels, Katharina, Benelkebir, Hanae, Pereira, Sara, Al-Jamal, Wafa T., Douglas, Leon, Duriez, Patrick J., Packham, Graham, Haufe, Günter, Ganesan, A.

“…[Display omitted] We report a series of tranylcypromine analogues containing a fluorine in the cyclopropyl ring. A number of compounds with additional m- or…”
Get full text

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity by Lecointre, Bertrand, Narozny, Remy, Borrello, Maria Teresa, Senger, Johanna, Chakrabarti, Alokta, Jung, Manfred, Marek, Martin, Romier, Christophe, Melesina, Jelena, Sippl, Wolfgang, Bischoff, Laurent, Ganesan, A.

“…A series of hydroxamic acids linked by different lengths to a chiral imidazoketopiperazine scaffold were synthesized. The compounds with linker lengths of 6…”
Get full text

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity by Lecointre, Bertrand, Narozny, Remy, Borrello, Maria Teresa, Senger, Johanna, Chakrabarti, Alokta, Jung, Manfred, Marek, Martin, Romier, Christophe, Melesina, Jelena, Sippl, Wolfgang, Bischoff, Laurent, Ganesan, A.

“…A series of hydroxamic acids linked by different lengths to a chiral imidazo-ketopiperazine scaffold were synthesized. The compounds with linker lengths of 6…”
Get full text

Protein Recognition by Short Peptide Reversible Inhibitors of the Chromatin-Modifying LSD1/CoREST Lysine Demethylase by Tortorici, Marcello, Borrello, Maria Teresa, Tardugno, Maria, Chiarelli, Laurent R, Pilotto, Simona, Ciossani, Giuseppe, Vellore, Nadeem A, Bailey, Sarah G, Cowan, Jonathan, O’Connell, Maria, Crabb, Simon J, Packham, Graham, Mai, Antonello, Baron, Riccardo, Ganesan, A, Mattevi, Andrea

“…The combinatorial assembly of protein complexes is at the heart of chromatin biology. Lysine demethylase LSD1(KDM1A)/CoREST beautifully exemplifies this…”
Get full text

Efficient synthesis and biological evaluation of proximicins A, B and C by Brucoli, Federico, Natoli, Antonino, Marimuthu, Preethi, Borrello, Maria Teresa, Stapleton, Paul, Gibbons, Simon, Schätzlein, Andreas

“…A quick and efficient synthesis and the biological evaluation of promising antitumor-antibiotics proximicins A, B and C are reported. The characteristic…”
Get full text

Efficient synthesis and biological evaluation of proximicins A, B and C: The Chemistry Biology Interface by BRUCOLI, Federico, NATOLI, Antonino, MARIMUTHU, Preethi, TERESA BORRELLO, Maria, STAPLETON, Paul, GIBBONS, Simon, SCHÄTZLEIN, Andreas

Get full text

Expanding the Druggable Space of the LSD1/CoREST Epigenetic Target: New Potential Binding Regions for Drug-Like Molecules, Peptides, Protein Partners, and Chromatin: e1003158 by Robertson, James C, Hurley, Nate C, Tortorici, Marcello, Ciossani, Giuseppe, Borrello, Maria Teresa, Vellore, Nadeem A, Ganesan, A, Mattevi, Andrea, Baron, Riccardo

“…Lysine specific demethylase-1 (LSD1/KDM1A) in complex with its corepressor protein CoREST is a promising target for epigenetic drugs. No therapeutic that…”
Get full text

Reversible and irreversible lsd1 inhibitors by Borrello, Maria Teresa

“…Environmental factors and lifestyle can alter the way our genes are expressed influencing a network of chemical switches within our cells collectively known as…”
Get full text