Search Results - "Borrell, Maria"

Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets by Badimon, Lina, Padro, Teresa, Arderiu, Gemma, Vilahur, Gemma, Borrell‐Pages, Maria, Suades, Rosa

“…Summary Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of global mortality. Extracellular vesicles (EVs) are small phospholipid…”
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Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons by Colin, Emilie, Zala, Diana, Liot, Géraldine, Rangone, Hélène, Borrell-Pagès, Maria, Li, Xiao-Jiang, Saudou, Frédéric, Humbert, Sandrine

“…The transport of vesicles in neurons is a highly regulated process, with vesicles moving either anterogradely or retrogradely depending on the nature of the…”
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Wnt pathway activation, cell migration, and lipid uptake is regulated by low-density lipoprotein receptor-related protein 5 in human macrophages by Borrell-Pagès, Maria, Romero, July Carolina, Juan-Babot, Oriol, Badimon, Lina

“…Aims Atherosclerosis plaque development includes infiltration of inflammatory cells, accumulation of lipids and fibrous cap formation. Low-density lipoprotein…”
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LRP5 deficiency down‐regulates Wnt signalling and promotes aortic lipid infiltration in hypercholesterolaemic mice by Borrell‐Pagès, Maria, Romero, July Carolina, Badimon, Lina

“…Low‐density lipoprotein receptor‐related protein 5 (LRP5) is a member of the LDLR family that orchestrates cholesterol homoeostasis. The role of LRP5 and the…”
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Macrophages of genetically characterized familial hypercholesterolaemia patients show up‐regulation of LDL‐receptor‐related proteins by Escate, Rafael, Padro, Teresa, Borrell‐Pages, Maria, Suades, Rosa, Aledo, Rosa, Mata, Pedro, Badimon, Lina

“…Familial hypercholesterolaemia (FH) is a major risk for premature coronary heart disease due to severe long‐life exposure to high LDL levels. Accumulation of…”
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PCSK9 and LRP5 in macrophage lipid internalization and inflammation by Badimon, Lina, Luquero, Aureli, Crespo, Javier, Peña, Esther, Borrell-Pages, Maria

“…Abstract Aims Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. Low-density…”
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Atheroma Burden and Morphology in Women by Badimon, Lina, Borrell-Pagès, María, Padró, Teresa

“…Ischemic heart disease is the major cause of death in women. Men and women have many similarities in relation to cardiovascular risk factors, but they differ…”
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LRP5 negatively regulates differentiation of monocytes through abrogation of Wnt signalling by Borrell‐Pagès, Maria, Romero, July Carolina, Badimon, Lina

“…Molecular changes involved in cell differentiation are only partially known. Circulating inflammatory cells need to differentiate to perform specialized…”
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Use of ctDNA in early breast cancer: analytical validity and clinical potential by Panet, François, Papakonstantinou, Andri, Borrell, Maria, Vivancos, Joan, Vivancos, Ana, Oliveira, Mafalda

“…Circulating free tumor DNA (ctDNA) analysis is gaining popularity in precision oncology, particularly in metastatic breast cancer, as it provides non-invasive,…”
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PCSK9 Functions in Atherosclerosis Are Not Limited to Plasmatic LDL-Cholesterol Regulation by Luquero, Aureli, Badimon, Lina, Borrell-Pages, Maria

“…The relevance of PCSK9 in atherosclerosis progression is demonstrated by the benefits observed in patients that have followed PCSK9-targeted therapies. The…”
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GSK3β inhibition and canonical Wnt signaling in mice hearts after myocardial ischemic damage by Badimon, Lina, Casaní, Laura, Camino-Lopez, Sandra, Juan-Babot, Oriol, Borrell-Pages, Maria

“…Myocardial infarction induces myocardial injury and tissue damage. During myocardial infarction strong cellular response is initiated to salvage the damaged…”
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Unique Splicing of Lrp5 in the Brain: A New Player in Neurodevelopment and Brain Maturation by Luquero, Aureli, Pimentel, Noelia, Vilahur, Gemma, Badimon, Lina, Borrell-Pages, Maria

“…Low-density lipoprotein receptor-related protein 5 (LRP5) is a constitutively expressed receptor with observed roles in bone homeostasis, retinal development,…”
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Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase by Borrell-Pagès, Maria, Canals, Josep M, Cordelières, Fabrice P, Parker, J Alex, Pineda, José R, Grange, Ghislaine, Bryson, Elzbieta A, Guillermier, Martine, Hirsch, Etienne, Hantraye, Philippe, Cheetham, Michael E, Néri, Christian, Alberch, Jordi, Brouillet, Emmanuel, Saudou, Frédéric, Humbert, Sandrine

“…There is no treatment for the neurodegenerative disorder Huntington disease (HD). Cystamine is a candidate drug; however, the mechanisms by which it operates…”
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Matrix metalloproteinase-13 is activated and is found in the nucleus of neural cells after cerebral ischemia by Cuadrado, Eloy, Rosell, Anna, Borrell-Pagès, Maria, García-Bonilla, Lidia, Hernández-Guillamon, Mar, Ortega-Aznar, Arantxa, Montaner, Joan

“…Matrix metalloproteinases (MMPs) have been implicated in the pathophysiology of ischemic stroke. In this study, we investigated the time course of…”
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Differential cholesterol uptake in liver cells: A role for PCSK9 by Luquero, Aureli, Vilahur, Gemma, Casani, Laura, Badimon, Lina, Borrell‐Pages, Maria

“…The clearance of low‐density lipoprotein (LDL) particles from the circulation is regulated by the LDL receptor (LDLR) and proprotein convertase…”
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Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules by Gauthier, Laurent R, Charrin, Bénédicte C, Borrell-Pagès, Maria, Dompierre, Jim P, Rangone, Hélène, Cordelières, Fabrice P, De Mey, Jan, MacDonald, Marcy E, Leßmann, Volkmar, Humbert, Sandrine, Saudou, Frédéric

“…Polyglutamine expansion (polyQ) in the protein huntingtin is pathogenic and responsible for the neuronal toxicity associated with Huntington's disease (HD)…”
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Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by β-amyloid 25-35 fragment by Hernández-Guillamon, Mar, Delgado, Pilar, Ortega, Laura, Pares, Mireia, Rosell, Anna, García-Bonilla, Lidia, Fernández-Cadenas, Israel, Borrell-Pagès, Maria, Boada, Mercè, Montaner, Joan

“…The neuropathology of Alzheimer's disease (AD) is accompanied by an inflammatory response that includes neurodegeneration and glial reactivity. Tissue…”
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Microvesicles carrying LRP5 induce macrophage polarization to an anti‐inflammatory phenotype by Luquero, Aureli, Vilahur, Gemma, Crespo, Javier, Badimon, Lina, Borrell‐Pages, Maria

“…Microvesicles (MV) contribute to cell‐to‐cell communication through their transported proteins and nucleic acids. MV, released into the extracellular space,…”
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LRP 5 deficiency down‐regulates Wnt signalling and promotes aortic lipid infiltration in hypercholesterolaemic mice by Borrell‐Pagès, Maria, Romero, July Carolina, Badimon, Lina

“…Abstract Low‐density lipoprotein receptor‐related protein 5 ( LRP 5) is a member of the LDLR family that orchestrates cholesterol homoeostasis. The role of LRP…”
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Nintedanib Reduces Muscle Fibrosis and Improves Muscle Function of the Alpha-Sarcoglycan-Deficient Mice by Alonso-Pérez, Jorge, Carrasco-Rozas, Ana, Borrell-Pages, Maria, Fernández-Simón, Esther, Piñol-Jurado, Patricia, Badimon, Lina, Wollin, Lutz, Lleixà, Cinta, Gallardo, Eduard, Olivé, Montse, Díaz-Manera, Jordi, Suárez-Calvet, Xavier

“…Sarcoglycanopathies are a group of recessive limb-girdle muscular dystrophies, characterized by progressive muscle weakness. Sarcoglycan deficiency produces…”
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