Search Results - "Borrell, J I"
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Porphycenes: facts and prospects in photodynamic therapy of cancer
Published in Current medicinal chemistry (01-04-2007)“…The photodynamic process induces cell damage and death by the combined effect of a photosensitizer (PS), visible light, and molecular oxygen, which generate…”
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Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma
Published in Journal of hematology and oncology (31-03-2017)“…Pharmacological inhibition of B cell receptor (BCR) signaling has recently emerged as an effective approach in a wide range of B lymphoid neoplasms. However,…”
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Necrotic cell death induced by photodynamic treatment of human lung adenocarcinoma A-549 cells with palladium(II)-tetraphenylporphycene
Published in International journal of oncology (01-05-2004)“…In this study we describe photodamaging and photokilling effects of palladium(II)-tetraphenylporphycene (PdTPPo) (previously incorporated into…”
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Recent advances in combinatorial chemistry applied to development of anti-HIV drugs
Published in Mini reviews in medicinal chemistry (01-01-2006)“…A compilation of combinatorial chemistry techniques applied to anti-HIV drug development is presented in this review. This synthetic strategy together with…”
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Selective Hydrolysis of 2,4-Diaminopyrimidine Systems: A Theoretical and Experimental Insight into an Old Rule
Published in Journal of organic chemistry (12-01-2001)“…Hydrolysis of the amino groups in condensed 2,4-diaminopyrimidine systems (1) has been used as a common method for the synthesis of oxo-substituted…”
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Synthesis and Biological Activity of 7-Oxo Substituted Analogues of 5-Deaza-5,6,7,8-tetrahydrofolic Acid (5-DATHF) and 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid (DDATHF)
Published in Journal of medicinal chemistry (05-07-2001)“…We recently described the syntheses of 12a−c, 4-amino-7-oxo substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid (5-DATHF), and…”
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Synthesis and Biological Activity of 4-Amino-7-oxo-Substituted Analogues of 5-Deaza-5,6,7,8-tetrahydrofolic Acid and 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid
Published in Journal of medicinal chemistry (27-08-1998)“…The 4-amino-7-oxo-substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid (5-DATHF) and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF) were…”
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Photosensitizing properties of palladium-tetraphenylporphycene on cultured tumour cells
Published in Anti-cancer drug design (01-04-2000)“…In this study we describe photokilling properties and effects on the mitotic index (MI) of cultured HeLa cells induced by palladium(II)-tetraphenylporphycene…”
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Primary, secondary, and tertiary structure of the core of a histone H1-like protein from the sperm of Mytilus
Published in The Journal of biological chemistry (05-05-1991)“…We have analyzed the structure of the trypsin-resistant core of the protein PL-II* of the sperm from Mytilus californianus. The peptide has a molecular mass of…”
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Uptake of tetraphenylporphycene and its photoeffects on actin and cytokeratin elements of HeLa cells
Published in Anti-cancer drug design (01-10-1997)“…In the present work we have continued our studies in the photobiological properties of the 2,7,12,17-tetraphenylporphycene (TPPo). In particular, the uptake,…”
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Photodamaging effects of tetraphenylporphycene in a human carcinoma cell line
Published in Anti-cancer drug design (01-03-1996)“…The photosensitizing effects of tetraphenylporphycene (TPPo) and light on HeLa cells, with emphasis on cell viability and the microtubular network, have been…”
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A Diversity-Oriented, Microwave-Assisted Synthesis of 4-oxo and 4-chloropyrido[2,3-d]pyrimidin-7(8H)-ones
Published in QSAR & combinatorial science (01-12-2004)“…A microwave‐assisted protocol for the synthesis of 4‐oxo and 4‐chloropyrido[2,3‐d]pyrimidin‐7(8H)‐ones, 13 and 9 respectively, bearing a carbon substituent at…”
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Solid phase vs. solution phase differential behavior: formation of a salicylate structure from a malondialdehyde moiety
Published in Molecular diversity (01-01-2000)“…Treatment of 2, solid supported synthetic equivalent of 3-formylchromone (4), and ethyl acetoacetate affords the salicylate structure 8 instead of the…”
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A simple synthesis of 2-methoxypyridine-3-carbonitriles
Published in Heterocycles (01-04-1993)Get full text
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Synthesis of 4-amino-8-cyanoquinazolines from enones and enals
Published in Heterocycles (01-10-1993)Get full text
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A synthesis of 1,2,3,4-tetrahydro-1,6-naphthyridines
Published in Heterocycles (01-10-1992)Get full text
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Synthesis of 2-cyanamino-4,6-diphenyl-pyridine-3-carbonitrile
Published in Heterocycles (01-04-1993)Get full text
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A three-component synthesis of pyrido[2,3- d]pyrimidines
Published in Tetrahedron letters (14-07-2003)“…A new, high yield multicomponent reaction providing multifunctionalized pyrido[2,3- d]pyrimidines in a microwave-assisted one-pot cyclocondensation of…”
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Diethyl 2,7-Dibromo-4H,5H- thieno[3,2-b:4,5-b‘]dipyrrole-3,6- dicarboxylate: A Key Intermediate for a Diversity Oriented Synthesis of 2,7,12,17-Tetraarylporphycenes
Published in Organic letters (02-03-2006)“…A new Suzuki-based strategy for the synthesis of 4,4‘-diaryl (or heteroaryl)-substituted 2,2‘-bipyrroles (10), precursors of 2,7,12,17-tetraaryl (or…”
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