Search Results - "Borreguero, Luis"

Femoral and Carotid Subclinical Atherosclerosis Association With Risk Factors and Coronary Calcium: The AWHS Study by Laclaustra, Martín, Casasnovas, José A, Fernández-Ortiz, Antonio, Fuster, Valentin, León-Latre, Monserrat, Jiménez-Borreguero, Luis J, Pocovi, Miguel, Hurtado-Roca, Yamilee, Ordovas, José M, Jarauta, Estibaliz, Guallar, Eliseo, Ibañez, Borja, Civeira, Fernando

“…Early subclinical atherosclerosis has been mainly researched in carotid arteries. The potential value of femoral arteries for improving the predictive capacity…”
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Exercise Triggers ARVC Phenotype in Mice Expressing a Disease-Causing Mutated Version of Human Plakophilin-2 by Cruz, Francisco M., PhD, Sanz-Rosa, David, PhD, Roche-Molina, Marta, PhD, García-Prieto, Jaime, BSc, García-Ruiz, José M., MD, Pizarro, Gonzalo, MD, Jiménez-Borreguero, Luis J., MD, Torres, Miguel, PhD, Bernad, Antonio, PhD, Ruíz-Cabello, Jesús, PhD, Fuster, Valentín, MD, PhD, Ibáñez, Borja, MD, PhD, Bernal, Juan A., PhD

“…Abstract Background Exercise has been proposed as a trigger for arrhythmogenic right ventricular cardiomyopathy (ARVC) phenotype manifestation; however,…”
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Cardiomyocyte calcineurin is required for the onset and progression of cardiac hypertrophy and fibrosis in adult mice by Martínez‐Martínez, Sara, Lozano‐Vidal, Noelia, López‐Maderuelo, María Dolores, Jiménez‐Borreguero, Luis J., Armesilla, Ángel Luis, Redondo, Juan Miguel

“…Previous studies have demonstrated that activation of calcineurin induces pathological cardiac hypertrophy (CH). In these studies, loss‐of‐function was mostly…”
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A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart by Nicolás-Ávila, José A., Lechuga-Vieco, Ana V., Esteban-Martínez, Lorena, Sánchez-Díaz, María, Díaz-García, Elena, Santiago, Demetrio J., Rubio-Ponce, Andrea, Li, Jackson LiangYao, Balachander, Akhila, Quintana, Juan A., Martínez-de-Mena, Raquel, Castejón-Vega, Beatriz, Pun-García, Andrés, Través, Paqui G., Bonzón-Kulichenko, Elena, García-Marqués, Fernando, Cussó, Lorena, A-González, Noelia, González-Guerra, Andrés, Roche-Molina, Marta, Martin-Salamanca, Sandra, Crainiciuc, Georgiana, Guzmán, Gabriela, Larrazabal, Jagoba, Herrero-Galán, Elías, Alegre-Cebollada, Jorge, Lemke, Greg, Rothlin, Carla V., Jimenez-Borreguero, Luis Jesús, Reyes, Guillermo, Castrillo, Antonio, Desco, Manuel, Muñoz-Cánoves, Pura, Ibáñez, Borja, Torres, Miguel, Ng, Lai Guan, Priori, Silvia G., Bueno, Héctor, Vázquez, Jesús, Cordero, Mario D., Bernal, Juan A., Enríquez, José A., Hidalgo, Andrés

“…Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of the beating heart. It is unclear whether these cells, which are…”
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Aging-Associated miR-217 Aggravates Atherosclerosis and Promotes Cardiovascular Dysfunction by de Yébenes, Virginia G., Briones, Ana M., Martos-Folgado, Inmaculada, Mur, Sonia M., Oller, Jorge, Bilal, Faiz, González-Amor, María, Méndez-Barbero, Nerea, Silla-Castro, Juan Carlos, Were, Felipe, Jiménez-Borreguero, Luis J., Sánchez-Cabo, Fátima, Bueno, Héctor, Salaices, Mercedes, Redondo, Juan Miguel, Ramiro, Almudena R.

“…OBJECTIVE:microRNAs are master regulators of gene expression with essential roles in virtually all biological processes. miR-217 has been associated with aging…”
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Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis by MacGrogan, Donal, D’Amato, Gaetano, Travisano, Stanislao, Martinez-Poveda, Beatriz, Luxán, Guillermo, del Monte-Nieto, Gonzalo, Papoutsi, Tania, Sbroggio, Mauro, Bou, Vanesa, Gomez-del Arco, Pablo, Gómez, Manuel Jose, Zhou, Bin, Redondo, Juan Miguel, Jiménez-Borreguero, Luis J, de la Pompa, José Luis

“…RATIONALE:The Notch signaling pathway is crucial for primitive cardiac valve formation by epithelial–mesenchymal transition, and NOTCH1 mutations cause…”
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Sequential Notch activation regulates ventricular chamber development by D’Amato, Gaetano, Luxán, Guillermo, del Monte-Nieto, Gonzalo, Martínez-Poveda, Beatriz, Torroja, Carlos, Walter, Wencke, Bochter, Matthew S., Benedito, Rui, Cole, Susan, Martinez, Fernando, Hadjantonakis, Anna-Katerina, Uemura, Akiyoshi, Jiménez-Borreguero, Luis J., de la Pompa, José Luis

“…Ventricular chambers are essential for the rhythmic contraction and relaxation occurring in every heartbeat throughout life. Congenital abnormalities in…”
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Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy by Luxán, Guillermo, Casanova, Jesús C, Martínez-Poveda, Beatriz, Prados, Belén, D'Amato, Gaetano, MacGrogan, Donal, Gonzalez-Rajal, Alvaro, Dobarro, David, Torroja, Carlos, Martinez, Fernando, Izquierdo-García, José Luis, Fernández-Friera, Leticia, Sabater-Molina, María, Kong, Young-Y, Pizarro, Gonzalo, Ibañez, Borja, Medrano, Constancio, García-Pavía, Pablo, Gimeno, Juan R, Monserrat, Lorenzo, Jiménez-Borreguero, Luis J, de la Pompa, José Luis

“…The Notch signaling pathway has a key role in shaping the developing heart. Guillermo Luxán et al . identify two human mutations in the gene encoding the Notch…”
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Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome by Oller, Jorge, Méndez-Barbero, Nerea, Ruiz, E Josue, Villahoz, Silvia, Renard, Marjolijn, Canelas, Lizet I, Briones, Ana M, Alberca, Rut, Lozano-Vidal, Noelia, Hurlé, María A, Milewicz, Dianna, Evangelista, Arturo, Salaices, Mercedes, Nistal, J Francisco, Jiménez-Borreguero, Luis Jesús, De Backer, Julie, Campanero, Miguel R, Redondo, Juan Miguel

“…Loss of the metalloproteinase Adamts1 leads to aortic pathology in mice due to increased NOS2-dependent NO production. Decreased Adamts1 expression, associated…”
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CD69 expression on regulatory T cells protects from immune damage after myocardial infarction by Blanco-Dominguez, Rafael, de la Fuente, Hortensia, Rodriguez, Cristina, Martin-Aguado, Laura, Sanchez-Diaz, Raquel, Jimenez-Alejandre, Rosa, Rodriguez-Arabaolaza, Iker, Curtabbi, Andrea, Garcia-Guimaraes, Marcos M, Vera, Alberto, Rivero, Fernando, Cuesta, Javier, Jimenez-Borreguero, Luis J, Cecconi, Alberto, Duran-Cambra, Albert, Tauron, Manel, Alonso, Judith, Bueno, Hector, Villalba-Orero, Maria, Enriquez, Jose Antonio, Robson, Simon C, Alfonso, Fernando, Sanchez-Madrid, Francisco, Martinez-Gonzalez, Jose, Martin, Pilar

“…Increasing evidence has pointed to the important function of T cells in controlling immune homeostasis and pathogenesis after myocardial infarction (MI),…”
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Myocardial Notch1-Rbpj deletion does not affect NOTCH signaling, heart development or function by Salguero-Jiménez, Alejandro, Grego-Bessa, Joaquim, D'Amato, Gaetano, Jiménez-Borreguero, Luis J, de la Pompa, José Luis

“…During vertebrate cardiac development NOTCH signaling activity in the endocardium is essential for the crosstalk between endocardium and myocardium that…”
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Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study by Fernández-Friera, Leticia, Peñalvo, José L, Fernández-Ortiz, Antonio, Ibañez, Borja, López-Melgar, Beatriz, Laclaustra, Martín, Oliva, Belén, Mocoroa, Agustín, Mendiguren, José, Martínez de Vega, Vicente, García, Laura, Molina, Jesús, Sánchez-González, Javier, Guzmán, Gabriela, Alonso-Farto, Juan C, Guallar, Eliseo, Civeira, Fernando, Sillesen, Henrik, Pocock, Stuart, Ordovás, José M, Sanz, Ginés, Jiménez-Borreguero, Luis Jesús, Fuster, Valentín

“…Data are limited on the presence, distribution, and extent of subclinical atherosclerosis in middle-aged populations. The PESA (Progression of Early…”
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Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation by Menendez-Montes, Ivan, Escobar, Beatriz, Palacios, Beatriz, Gómez, Manuel Jose, Izquierdo-Garcia, Jose Luis, Flores, Lorena, Jiménez-Borreguero, Luis Jesus, Aragones, Julian, Ruiz-Cabello, Jesus, Torres, Miguel, Martin-Puig, Silvia

“…While gene regulatory networks involved in cardiogenesis have been characterized, the role of bioenergetics remains less studied. Here we show that until…”
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A Novel Circulating MicroRNA for the Detection of Acute Myocarditis by Blanco-Domínguez, Rafael, Sánchez-Díaz, Raquel, de la Fuente, Hortensia, Jiménez-Borreguero, Luis J, Matesanz-Marín, Adela, Relaño, Marta, Jiménez-Alejandre, Rosa, Linillos-Pradillo, Beatriz, Tsilingiri, Katerina, Martín-Mariscal, María L, Alonso-Herranz, Laura, Moreno, Guillermo, Martín-Asenjo, Roberto, García-Guimaraes, Marcos M, Bruno, Katelyn A, Dauden, Esteban, González-Álvaro, Isidoro, Villar-Guimerans, Luisa M, Martínez-León, Amaia, Salvador-Garicano, Ane M, Michelhaugh, Sam A, Ibrahim, Nasrien E, Januzzi, James L, Kottwitz, Jan, Iliceto, Sabino, Plebani, Mario, Basso, Cristina, Baritussio, Anna, Seguso, Mara, Marcolongo, Renzo, Ricote, Mercedes, Fairweather, DeLisa, Bueno, Héctor, Fernández-Friera, Leticia, Alfonso, Fernando, Caforio, Alida L.P, Pascual-Figal, Domingo A, Heidecker, Bettina, Lüscher, Thomas F, Das, Saumya, Fuster, Valentín, Ibáñez, Borja, Sánchez-Madrid, Francisco, Martín, Pilar

“…Using microRNA microarray analysis of Th17 cells in mice with myocarditis or myocardial infarction, investigators found that the microRNA mmu-miR-721 was…”
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Deletion of Fstl1 (Follistatin-Like 1) From the Endocardial/Endothelial Lineage Causes Mitral Valve Disease by Prakash, Stuti, Borreguero, Luis J.J, Sylva, Marc, Flores Ruiz, Lorena, Rezai, Fereshte, Gunst, Quinn D, de la Pompa, José-Luis, Ruijter, Jan M, van den Hoff, Maurice J.B

“…OBJECTIVE—Fstl1 (Follistatin-like 1) is a secreted protein that is expressed in the atrioventricular valves throughout embryonic development, postnatal…”
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Energy substrate metabolism, mitochondrial structure and oxidative stress after cardiac ischemia-reperfusion in mice lacking UCP3 by Sánchez-Pérez, Patricia, Mata, Ana, Torp, May-Kristin, López-Bernardo, Elia, Heiestad, Christina M., Aronsen, Jan Magnus, Molina-Iracheta, Antonio, Jiménez-Borreguero, Luis J., García-Roves, Pablo, Costa, Ana S.H., Frezza, Christian, Murphy, Michael P., Stenslokken, Kåre-Olav, Cadenas, Susana

“…Myocardial ischemia-reperfusion (IR) injury may result in cardiomyocyte dysfunction. Mitochondria play a critical role in cardiomyocyte recovery after IR…”
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CD69 Limits the Severity of Cardiomyopathy After Autoimmune Myocarditis by CRUZ-ADALIA, Aranzazu, JIMENEZ-BORREGUERO, Luis Jesús, RAMIREZ-HUESCA, Marta, CHICO-CALERO, Isabel, BARREIRO, Olga, LOPEZ-CONESA, Erica, FRESNO, Manuel, SANCHEZ-MADRID, Francisco, MARTIN, Pilar

“…Experimental autoimmune myocarditis (EAM), a mouse model of post-infectious cardiomyopathy, reflects mechanisms of inflammatory cardiomyopathy in humans. EAM…”
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Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis by de Cárcer, Guillermo, Wachowicz, Paulina, Martínez-Martínez, Sara, Oller, Jorge, Méndez-Barbero, Nerea, Escobar, Beatriz, González-Loyola, Alejandra, Takaki, Tohru, El Bakkali, Aicha, Cámara, Juan A, Jiménez-Borreguero, Luis J, Bustelo, Xosé R, Cañamero, Marta, Mulero, Francisca, de los Ángeles Sevilla, María, Montero, María Jose, Redondo, Juan Miguel, Malumbres, Marcos

“…The kinase Plk1 has been studied primarily as a mitotic regulator in dividing cells, but de Cárcer et al . find that Plk1 deficiency or inhibition in mice…”
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Left Atrial Strain Predicts Stroke Recurrence and Death in Patients with Cryptogenic Stroke by Vera, Alberto, Cecconi, Alberto, Ximénez-Carrillo, Álvaro, Ramos, Carmen, Martínez-Vives, Pablo, Lopez-Melgar, Beatriz, Sanz-García, Ancor, Ortega, Guillermo, Aguirre, Clara, Montes, Álvaro, Vivancos, José, Jiménez-Borreguero, Luis Jesús, Alfonso, Fernando

“…Left atrial strain (LAS) has been widely studied as predictor of atrial fibrillation (AF) after cryptogenic stroke (CS). However, the evidence about its…”
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Spontaneous Pulmonary Hypertension Associated With Systemic Sclerosis in P‐Selectin Glycoprotein Ligand 1–Deficient Mice by González‐Tajuelo, Rafael, Fuente‐Fernández, María, Morales‐Cano, Daniel, Muñoz‐Callejas, Antonio, González‐Sánchez, Elena, Silván, Javier, Serrador, Juan Manuel, Cadenas, Susana, Barreira, Bianca, Espartero‐Santos, Marina, Gamallo, Carlos, Vicente‐Rabaneda, Esther F., Castañeda, Santos, Pérez‐Vizcaíno, Francisco, Cogolludo, Ángel, Jiménez‐Borreguero, Luis Jesús, Urzainqui, Ana

“…Objective Pulmonary arterial hypertension (PAH), one of the major complications of systemic sclerosis (SSc), is a rare disease with unknown etiopathogenesis…”
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