Search Results - "Borradaile, Nica M."

Mushroom-Derived Medicine? Preclinical Studies Suggest Potential Benefits of Ergothioneine for Cardiometabolic Health by Lam-Sidun, Daniel, Peters, Kia M, Borradaile, Nica M

“…Medicinal use of mushrooms has been documented since ancient times, and in the modern world, mushrooms have a longstanding history of use in Eastern medicine…”
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Non-parenchymal hepatic cell lipotoxicity and the coordinated progression of non-alcoholic fatty liver disease and atherosclerosis by Peters, Kia M, Wilson, Rachel B, Borradaile, Nica M

“…Non-alcoholic fatty liver disease (NAFLD) appears to be independently associated with the development of atherosclerosis. The biological mechanisms underlying…”
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Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death by Borradaile, Nica M., Han, Xianlin, Harp, Jeffrey D., Gale, Sarah E., Ory, Daniel S., Schaffer, Jean E.

“…Cell dysfunction and death induced by lipid accumulation in nonadipose tissues, or lipotoxicity, may contribute to the pathogenesis of obesity and type 2…”
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Differential Lipotoxic Effects of Palmitate and Oleate in Activated Human Hepatic Stellate Cells and Epithelial Hepatoma Cells by Hetherington, Alexandra M., Sawyez, Cynthia G., Zilberman, Emma, Stoianov, Alexandra M., Robson, Debra L., Borradaile, Nica M.

“…Background/Aims: Nonalcoholic fatty liver disease (NAFLD) progression to fibrosis, cirrhosis and hepatocellular carcinoma, alters the cellular composition of…”
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The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease by Wilson, Rachel B., Chen, Yun Jin, Sutherland, Brian G., Sawyez, Cynthia G., Zhang, Richard, Woolnough, Taylor, Hetherington, Alexandra M., Peters, Kia M., Patel, Krisha, Kennelly, John P., Leonard, Kelly-Ann, Schuurman, Meg, Jacobs, René L., Wang, Rennian, Borradaile, Nica M.

“…[Display omitted] •Elongation factor 1A1 inhibitor didemnin B improves fatty liver, glucose tolerance, and blood lipids in obesity.•Didemnin B moderately…”
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Two-Week Isocaloric Time-Restricted Feeding Decreases Liver Inflammation without Significant Weight Loss in Obese Mice with Non-Alcoholic Fatty Liver Disease by Wilson, Rachel B, Zhang, Richard, Chen, Yun Jin, Peters, Kia M, Sawyez, Cynthia G, Sutherland, Brian G, Patel, Krisha, Kennelly, John P, Leonard, Kelly-Ann, Jacobs, René L, Wang, Rennian, Borradaile, Nica M

“…Prolonged, isocaloric, time-restricted feeding (TRF) protocols can promote weight loss, improve metabolic dysregulation, and mitigate non-alcoholic fatty liver…”
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Elongation Factor 1A-1 Is a Mediator of Hepatocyte Lipotoxicity Partly through Its Canonical Function in Protein Synthesis by Stoianov, Alexandra M, Robson, Debra L, Hetherington, Alexandra M, Sawyez, Cynthia G, Borradaile, Nica M

“…Elongation factor 1A-1 (eEF1A-1) has non-canonical functions in regulation of the actin cytoskeleton and apoptosis. It was previously identified through a…”
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Microarray data and pathway analyses for human microvascular endothelial cells supplemented with low dose vitamin D or niacin during lipotoxicity by Peters, Kia M., Borradaile, Nica M.

“…Low dose niacin and vitamin D can directly improve human microvascular endothelial cell angiogenic function under lipotoxic conditions Peters et al.,2019…”
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A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death by Borradaile, Nica M, Buhman, Kimberly K, Listenberger, Laura L, Magee, Carolyn J, Morimoto, Emiko T A, Ory, Daniel S, Schaffer, Jean E

“…The deleterious consequences of fatty acid (FA) and neutral lipid accumulation in nonadipose tissues, such as the heart, contribute to the pathogenesis of type…”
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Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves Activation of the Mitogen-Activated Protein Kinase Pathway in Hepatocytes by ALLISTER, Emma M, BORRADAILE, Nica M, EDWARDS, Jane Y, HUFF, Murray W

“…Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves…”
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Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation by BORRADAILE, Nica M, DE DREU, Linda E, HUFF, Murray W

“…Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of…”
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Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP by Wilcox, L J, Borradaile, N M, de Dreu, L E, Huff, M W

“…The citrus flavonoids, naringenin and hesperetin, lower plasma cholesterol in vivo. However, the underlying mechanisms are not fully understood. The ability of…”
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Gene expression microarray data from human microvascular endothelial cells supplemented with a low concentration of niacin by Hughes-Large, Jennifer M., Borradaile, Nica M.

“…The systemic lipid modifying drug, niacin, can directly improve human microvascular endothelial cell angiogenic function under lipotoxic conditions, possibly…”
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Microarray data and pathway analyses for primary human activated hepatic stellate cells compared to HepG2 human hepatoma cells by Hetherington, Alexandra M., Sawyez, Cynthia G., Borradaile, Nica M.

“…As nonalcoholic fatty liver disease progresses to end-stage diseases, including fibrosis, cirrhosis and hepatocellular carcinoma, fibrotic activated hepatic…”
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Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms by Borradaile, Nica M, de Dreu, Linda E, Wilcox, Lisa J, Edwards, Jane Y, Huff, Murray W

“…Diets containing the soya-derived phytoestrogens, genistein and daidzein, decrease plasma cholesterol in humans and experimental animals. The mechanisms…”
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Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin by Borradaile, N.M, Carroll, K.K, Kurowska, E.M

“…Our previous studies showed that replacing the drinking water of rabbits fed a casein‐containing diet with either orange juice or grapefruit juice reduced…”
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Elongation factor 1A1 regulates metabolic substrate preference in mammalian cells by Wilson, Rachel B., Kozlov, Alexandra M., Hatam Tehrani, Helia, Twumasi-Ankrah, Jessica S., Chen, Yun Jin, Borrelli, Matthew J., Sawyez, Cynthia G., Maini, Siddhant, Shepherd, Trevor G., Cumming, Robert C., Betts, Dean H., Borradaile, Nica M.

“…Eukaryotic elongation factor 1A1 (EEF1A1) is canonically involved in protein synthesis but also has noncanonical functions in diverse cellular processes…”
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Nicotinamide phosphoribosyltransferase imparts human endothelial cells with extended replicative lifespan and enhanced angiogenic capacity in a high glucose environment by Borradaile, Nica M., Pickering, J. Geoffrey

“…Summary Endothelial dysfunction is a characteristic of aging‐related vascular disease and is worsened during diabetes. High glucose can impair endothelial cell…”
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Pannexin 3 deletion reduces fat accumulation and inflammation in a sex-specific manner by Wakefield, C. Brent, Lee, Vanessa R., Johnston, Danielle, Boroumand, Parastoo, Pillon, Nicolas J., Sayedyahossein, Samar, O’Donnell, Brooke L., Tang, Justin, Sanchez-Pupo, Rafael E., Barr, Kevin J., Gros, Robert, Flynn, Lauren, Borradaile, Nica M., Klip, Amira, Beier, Frank, Penuela, Silvia

“…Background Pannexin 3 (PANX3) is a channel-forming glycoprotein that enables nutrient-induced inflammation in vitro, and genetic linkage data suggest that it…”
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NAD(+), sirtuins, and cardiovascular disease by Borradaile, Nica M, Pickering, J Geoffrey

“…Cardiovascular disease (CVD) is the most prevalent disease worldwide and there is intense interest in pharmaceutical approaches to reduce the burden of this…”
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