Search Results - "Borowski, Christopher"

Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants by Weinmann, Jonas, Weis, Sabrina, Sippel, Josefine, Tulalamba, Warut, Remes, Anca, El Andari, Jihad, Herrmann, Anne-Kathrin, Pham, Quang H., Borowski, Christopher, Hille, Susanne, Schönberger, Tanja, Frey, Norbert, Lenter, Martin, VandenDriessche, Thierry, Müller, Oliver J., Chuah, Marinee K., Lamla, Thorsten, Grimm, Dirk

“…Adeno-associated virus (AAV) forms the basis for several commercial gene therapy products and for countless gene transfer vectors derived from natural or…”
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Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue by Remes, Anca, Basha, Dima Ibrahim, Puehler, Thomas, Borowski, Christopher, Hille, Susanne, Kummer, Laura, Wagner, Andreas H., Hecker, Markus, Soethoff, Jasmin, Lutter, Georg, Frank, Derk, Arif, Rawa, Frey, Norbert, Zaradzki, Marcin, Müller, Oliver J.

“…Gene therapeutic approaches to aortic diseases require efficient vectors and delivery systems for transduction of endothelial cells (ECs) and smooth muscle…”
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RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation by Bartsch, Kareen, Damme, Markus, Regen, Tommy, Becker, Lore, Garrett, Lillian, Hölter, Sabine M, Knittler, Katharina, Borowski, Christopher, Waisman, Ari, Glatzel, Markus, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabe de Angelis, Martin, Rabe, Björn

“…Aicardi-Goutières syndrome (AGS) is a rare early onset childhood encephalopathy caused by persistent neuroinflammation of autoimmune origin. AGS is a genetic…”
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Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy by Bartsch, Kareen, Knittler, Katharina, Borowski, Christopher, Rudnik, Sönke, Damme, Markus, Aden, Konrad, Spehlmann, Martina E, Frey, Norbert, Saftig, Paul, Chalaris, Athena, Rabe, Björn

“…Hypomorphic mutations in the DNA repair enzyme RNase H2 cause the neuroinflammatory autoimmune disorder Aicardi-Goutières syndrome (AGS). Endogenous nucleic…”
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AAV-mediated TIMP-1 overexpression in aortic tissue reduces the severity of allograft vasculopathy in mice by Remes, Anca, Franz, Maximilian, Zaradzki, Marcin, Borowski, Christopher, Frey, Norbert, Karck, Matthias, Kallenbach, Klaus, Müller, Oliver J., Wagner, Andreas H., Arif, Rawa

“…Allograft vasculopathy (AV) is the primary limiting factor for long-term graft survival. An increased activity of matrix metalloproteinases (MMPs) contributes…”
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