Search Results - "Borowitz, J.L."

Upregulation of BNIP3 and translocation to mitochondria mediates cyanide-induced apoptosis in cortical cells by Prabhakaran, K, Li, L, Zhang, L, Borowitz, J.L, Isom, G.E

“…Abstract Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3), a Bcl-2 homology domain 3 (BH3) domain only protein, has been identified as a mitochondrial…”
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Receptor mechanisms mediating cyanide generation in PC12 cells and rat brain by Gunasekar, P.G, Prabhakaran, K, Li, L, Zhang, L, Isom, G.E, Borowitz, J.L

“…Cyanide is generated in neurons and this report examines the two different receptors which mediate cyanide formation in neuronal tissue. An opiate receptor…”
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Endogenous generation of cyanide in neuronal tissue: Involvement of a peroxidase system by Gunasekar, P.G., Borowitz, J.L., Turek, J.J., Van Horn, D.A., Isom, G.E.

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Accumulation of labeled cyanide in neuronal tissue by Borowitz, J L, Rathinavelu, A, Kanthasamy, A, Wilsbacher, J, Isom, G E

“…Since cyanide is a reactive chemical substance and has the potential of forming a variety of adducts in biological systems, the rate of accumulation of labeled…”
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HIF-1α activation by a redox-sensitive pathway mediates cyanide-induced BNIP3 upregulation and mitochondrial-dependent cell death by Zhang, L., Li, L., Liu, H., Prabhakaran, K., Zhang, X., Borowitz, J.L., Isom, G.E.

“…Cyanide produces degeneration of the nervous system in which different modes of cell death are activated in the vulnerable brain areas. In brain, the mechanism…”
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1α,25-dihydroxyvitamin D3 attenuates cyanide-induced neurotoxicity by inhibiting uncoupling protein-2 up-regulation by Li, L., Prabhakaran, K., Zhang, X., Zhang, L., Liu, H., Borowitz, J.L., Isom, G.E.

“…1α,25‐dihydroxyvitamin D3 (VD3) is a neuroprotectant that can reduce cytotoxicity produced by a variety of toxicants. The mechanism of the neuroprotection was…”
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Trimethyltin-induced apoptosis is associated with upregulation of inducible nitric oxide synthase and Bax in a hippocampal cell line by Zhang, L., Li, L., Prabhakaran, K., Borowitz, J.L., Isom, G.E.

“…Trimethyltin (TMT) produces selective neuronal degeneration in the central nervous system (CNS), in which the hippocampus is the most sensitive area. Since…”
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Cyanide-induced death of dopaminergic cells is mediated by uncoupling protein-2 up-regulation and reduced Bcl-2 expression by Zhang, X., Li, L., Zhang, L., Borowitz, J.L., Isom, G.E.

“…Cyanide is a potent inhibitor of mitochondrial oxidative metabolism and produces mitochondria-mediated death of dopaminergic neurons and sublethal…”
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1α,25‐dihydroxyvitamin D 3 attenuates cyanide‐induced neurotoxicity by inhibiting uncoupling protein‐2 up‐regulation by Li, L., Prabhakaran, K., Zhang, X., Zhang, L., Liu, H., Borowitz, J.L., Isom, G.E.

“…1α,25‐dihydroxyvitamin D 3 (VD 3 ) is a neuroprotectant that can reduce cytotoxicity produced by a variety of toxicants. The mechanism of the neuroprotection…”
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Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPAR{alpha} activation and oxidative stress by Zhang, X., Li, L., Prabhakaran, K., Zhang, L., Leavesley, H.B., Borowitz, J.L., Isom, G.E.

“…Uncoupling protein 2 (UCP-2) is an inner mitochondrial membrane proton carrier that modulates mitochondrial membrane potential ({delta}{psi}{sub m}) and…”
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Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARα activation and oxidative stress by Zhang, X., Li, L., Prabhakaran, K., Zhang, L., Leavesley, H.B., Borowitz, J.L., Isom, G.E.

“…Uncoupling protein 2 (UCP-2) is an inner mitochondrial membrane proton carrier that modulates mitochondrial membrane potential (Δ Ψ m) and uncouples oxidative…”
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Inducible nitric oxide synthase up-regulation and mitochondrial glutathione depletion mediate cyanide-induced necrosis in mesencephalic cells by Prabhakaran, K., Li, L., Borowitz, J.L., Isom, G.E.

“…We have previously shown in rat primary cultured mesencephalic cells that cyanide induces a high level of oxidative stress and necrotic death. To evaluate the…”
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Effect of acetylcholine on the subcellular distribution of 45Ca in bovine adrenal medulla by Borowitz, J L

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Oxidative Stress and Cyclooxygenase-2 Induction Mediate Cyanide-Induced Apoptosis of Cortical Cells by Li, L., Prabhakaran, K., Shou, Y., Borowitz, J.L., Isom, G.E.

“…Cyanide (KCN)-induced generation of reactive oxygen species (ROS) involves cyclooxygenase-2 (COX-2)-mediated reactions in some neurons. The present study…”
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Monitoring intracellular nitric oxide formation by dichlorofluorescin in neuronal cells by Gunasekar, P.G., Kanthasamy, A.G., Borowitz, J.L., Isom, G.E.

“…A method for rapid fluorometric assay of intracellular nitric oxide (NO) formation was developed for use in cultured neuronal cells. In a cell-free system…”
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Endogenous generation of cyanide in neuronal tissue: Involvement of a peroxidase system by Gunasekar, P.G., Borowitz, J.L., Turek, J.J., Van Horn, D.A., Isom, G.E.

“…In a study of the mechanism by which cyanide is produced in neural tissue, it was hypothesized that nerve cells generate cyanide in a manner similar to that in…”
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Cyanide-induced neurodegeneration involves multiple pathways in select brain areas by Isom, G.E., Mills, E.M., Borowitz, J.L., Gunasekar, P.G.

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Cyanide-induced lipid peroxidation in different organs: subcellular distribution and hydroperoxide generation in neuronal cells by Ardelt, B K, Borowitz, J L, Maduh, E U, Swain, S L, Isom, G E

“…To evaluate hydroperoxide generation as a potential mechanism of cyanide neurotoxicity, mice were treated with KCN (7 mg/kg, subcutaneously (s.c.)) and the…”
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Dopaminergic neurotoxicity of cyanide: neurochemical, histological, and behavioral characterization by Kanthasamy, A G, Borowitz, J L, Pavlakovic, G, Isom, G E

“…Previous reports have shown that dopamine (DA) is depleted in the brains of animals treated with cyanide. To develop a model for studying the mechanisms of…”
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Antagonism of cyanide toxicity by isosorbide dinitrate: possible role of nitric oxide by Sun, P., Borowitz, J.L., Kanthasamy, A.G., Kane, M.D., Gunasekar, P.G., Isom, G.E.

“…In a search for improved cyanide antidotes, the efficacy of isosorbide dinitrate (ISDN), was compared with that of the known cyanide antidote, NaNO 2. ISDN was…”
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