Search Results - "Borovjagin, Anton"

Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell–Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine by Gao, Ling, Gregorich, Zachery R, Zhu, Wuqiang, Mattapally, Saidulu, Oduk, Yasin, Lou, Xi, Kannappan, Ramaswamy, Borovjagin, Anton V, Walcott, Gregory P, Pollard, Andrew E, Fast, Vladimir G, Hu, Xinyang, Lloyd, Steven G, Ge, Ying, Zhang, Jianyi

“…BACKGROUND:Here, we generated human cardiac muscle patches (hCMPs) of clinically relevant dimensions (4 cm × 2 cm × 1.25 mm) by suspending cardiomyocytes,…”
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Regenerative Potential of Neonatal Porcine Hearts by Zhu, Wuqiang, Zhang, Eric, Zhao, Meng, Chong, Zechen, Fan, Chengming, Tang, Yawen, Hunter, Jervaughn D, Borovjagin, Anton V, Walcott, Gregory P, Chen, Jake Y, Qin, Gangjian, Zhang, Jianyi

“…BACKGROUND:Rodent hearts can regenerate myocardium lost to apical resection or myocardial infarction for up to 7 days after birth, but whether a similar window…”
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Spheroids of cardiomyocytes derived from human-induced pluripotent stem cells improve recovery from myocardial injury in mice by Mattapally, Saidulu, Zhu, Wuqiang, Fast, Vladimir G, Gao, Ling, Worley, Chelsea, Kannappan, Ramaswamy, Borovjagin, Anton V, Zhang, Jianyi

“…The microenvironment of native heart tissue may be better replicated when cardiomyocytes are cultured in three-dimensional clusters (i.e., spheroids) than in…”
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Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction by Zhao, Meng, Nakada, Yuji, Wei, Yuhua, Bian, Weihua, Chu, Yuxin, Borovjagin, Anton V., Xie, Min, Zhu, Wuqiang, Nguyen, Thanh, Zhou, Yang, Serpooshan, Vahid, Walcott, Gregory P., Zhang, Jianyi

“…Human induced pluripotent stem cells with normal (wild-type) or upregulated (overexpressed) levels of CCND2 (cyclin D2) expression were differentiated into…”
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VEGF nanoparticles repair the heart after myocardial infarction by Oduk, Yasin, Zhu, Wuqiang, Kannappan, Ramaswamy, Zhao, Meng, Borovjagin, Anton V, Oparil, Suzanne, Zhang, Jianyi Jay

“…Vascular endothelial growth factor (VEGF) is a well-characterized proangiogenic cytokine that has been shown to promote neovascularization in hearts of…”
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From Microscale Devices to 3D Printing: Advances in Fabrication of 3D Cardiovascular Tissues by Borovjagin, Anton V, Ogle, Brenda M, Berry, Joel L, Zhang, Jianyi

“…Current strategies for engineering cardiovascular cells and tissues have yielded a variety of sophisticated tools for studying disease mechanisms, for…”
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KISS1 in breast cancer progression and autophagy by Ulasov, Ilya V., Borovjagin, Anton V., Timashev, Peter, Cristofanili, Massimo, Welch, Danny R.

“…Tumor suppressors are cellular proteins typically expressed in normal (non-cancer) cells that not only regulate such cellular functions as proliferation,…”
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Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice by Zhao, Meng, Fan, Chengming, Ernst, Patrick J, Tang, Yawen, Zhu, Hanxi, Mattapally, Saidulu, Oduk, Yasin, Borovjagin, Anton V, Zhou, Lufang, Zhang, Jianyi, Zhu, Wuqiang

“…Abstract Aims  The effectiveness of cell-based treatments for regenerative myocardial therapy is limited by low rates of cell engraftment. Y-27632 inhibits…”
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Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX by Kaverina, Natalya V., Kadagidze, Zaira G., Borovjagin, Anton V., Karseladze, Apollon I., Kim, Chung Kwon, Lesniak, Maciej S., Miska, Jason, Zhang, Peng, Baryshnikova, Maria A., Xiao, Ting, Ornelles, David, Cobbs, Charles, Khramtsov, Andrey, Ulasov, Ilya V.

“…Autophagy is an evolutionarily conserved process regulating cellular homeostasis via digestion of dysfunctional proteins and whole cellular organelles by…”
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Genetic strategy to decrease complement activation with adenoviral therapies by Gentile, Christopher M, Borovjagin, Anton V, Richter, Jillian R, Jani, Aditi H, Wu, Hongju, Zinn, Kurt R, Warram, Jason M

“…A major obstacle to using recombinant adenoviral vectors in gene therapy is the natural ability of human adenovirus to activate the classical and alternate…”
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KISS1 tumor suppressor restricts angiogenesis of breast cancer brain metastases and sensitizes them to oncolytic virotherapy in vitro by Platonov, Mikhail E., Borovjagin, Anton V., Kaverina, Natalya, Xiao, Ting, Kadagidze, Zaira, Lesniak, Maciej, Baryshnikova, Marya, Ulasov, Ilya V.

“…KISS1 tumor suppressor protein regulates cancer cell invasion via MMP9 metalloproteinase. Downregulation of KISS1 gene expression promotes progression of…”
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Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy by Kaverina, Natalya, Borovjagin, Anton V., Kadagidze, Zaira, Baryshnikov, Anatoly, Baryshnikova, Maria, Malin, Dmitry, Ghosh, Dhimankrishhna, Shah, Nameeta, Welch, Danny R., Gabikian, Patrik, Karseladze, Apollon, Cobbs, Charles, Ulasov, Ilya V.

“…Formation of metastases, also known as cancer dissemination, is an important stage of breast cancer (BrCa) development. KISS1 expression is associated with…”
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Battling Neurodegenerative Diseases with Adeno-Associated Virus-Based Approaches by Mijanović, Olja, Branković, Ana, Borovjagin, Anton, Butnaru, Denis V, Bezrukov, Evgeny A, Sukhanov, Roman B, Shpichka, Anastasia, Timashev, Peter, Ulasov, Ilya

“…Neurodegenerative diseases (NDDs) are most commonly found in adults and remain essentially incurable. Gene therapy using AAV vectors is a rapidly-growing field…”
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Reabsorbable Pins can Reinforce an Early Sternal Stability After Median Sternotomy in Young Children with Congenital Heart Disease by Fan, Chengming, Tang, Mi, Wu, Sijie, Yuan, Shuwen, Borovjagin, Anton V., Yang, Jinfu

“…We evaluated the efficacy of bioresorbable sternal reinforcement device (poly- l -lactide sternal pins) on sternal healing after median sternotomy in young…”
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Successful Surgical Treatment of a Giant Left Coronary Artery Aneurysm with Fistula by Li, Huadong, Yu, Hong, Song, Yu, Tong, Lu, Zhao, Meng, Borovjagin, Anton V, Dong, Nianguo, Wu, Long

“…Coronary artery aneurysm (CAA) is an aortic catastrophe with low prevalence. Giant CAA is even more uncommon, requiring surgical intervention. Giant CAA…”
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MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo by Ulasov, Ilya, Borovjagin, Anton V, Kaverina, Natalya, Schroeder, Brett, Shah, Nameeta, Lin, Biaoyang, Baryshnikov, Anatoly, Cobbs, Charles

“…Highlights • GBM exhibits high levels of MMP14 expression. • Suppression of MMP14 expression by poly-MMP inhibitor Marimastat inhibits glioma angiogenesis. •…”
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Metabolome-Driven Regulation of Adenovirus-Induced Cell Death by Laevskaya, Anastasia, Borovjagin, Anton, Timashev, Peter S, Lesniak, Maciej S, Ulasov, Ilya

“…A viral infection that involves virus invasion, protein synthesis, and virion assembly is typically accompanied by sharp fluctuations in the intracellular…”
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Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient‐derived xenografts by Rab, Regina, Ehrhardt, Annette, Achyut, Bhagelu R., Joshi, Disha, Gilbert‐Ross, Melissa, Huang, Chunzi, Floyd, Katharine, Borovjagin, Anton V., Parker, William B., Sorscher, Eric J., Hong, Jeong S.

“…Background Purine nucleoside phosphorylase (PNP) gene transfer represents a promising approach to treatment of head and neck malignancies. We tested…”
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Calreticulin is important for the development of renal fibrosis and dysfunction in diabetic nephropathy by Lu, Ailing, Pallero, Manuel A., Owusu, Benjamin Y., Borovjagin, Anton V., Lei, Weiqi, Sanders, Paul W., Murphy-Ullrich, Joanne E.

“…Previously, our lab showed that the endoplasmic reticulum (ER) and calcium regulatory protein, calreticulin (CRT), is important for collagen transcription,…”
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HIV antigen incorporation within adenovirus hexon hypervariable 2 for a novel HIV vaccine approach by Matthews, Qiana L, Fatima, Aiman, Tang, Yizhe, Perry, Brian A, Tsuruta, Yuko, Komarova, Svetlana, Timares, Laura, Zhao, Chunxia, Makarova, Natalia, Borovjagin, Anton V, Stewart, Phoebe L, Wu, Hongju, Blackwell, Jerry L, Curiel, David T

“…Adenoviral (Ad) vectors have been used for a variety of vaccine applications including cancer and infectious diseases. Traditionally, Ad-based vaccines are…”
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