Search Results - "Boroughs, Lindsey K."

Metabolic pathways promoting cancer cell survival and growth by Boroughs, Lindsey K., DeBerardinis, Ralph J.

“…Burroughs and DeBerardinis discuss the metabolic pathways that tumour cells employ to promote their survival and proliferation, and present the current…”
Get full text

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects by Mullen, Andrew R., Hu, Zeping, Shi, Xiaolei, Jiang, Lei, Boroughs, Lindsey K., Kovacs, Zoltan, Boriack, Richard, Rakheja, Dinesh, Sullivan, Lucas B., Linehan, W. Marston, Chandel, Navdeep S., DeBerardinis, Ralph J.

“…Mammalian cells generate citrate by decarboxylating pyruvate in the mitochondria to supply the tricarboxylic acid (TCA) cycle. In contrast, hypoxia and other…”
Get full text

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells by Antonyak, Marc A, Li, Bo, Boroughs, Lindsey K, Johnson, Jared L, Druso, Joseph E, Bryant, Kirsten L, Holowka, David A, Cerione, Richard A

“…Tumor progression involves the ability of cancer cells to communicate with each other and with neighboring normal cells in their microenvironment…”
Get full text

A Unique Role for Heat Shock Protein 70 and Its Binding Partner Tissue Transglutaminase in Cancer Cell Migration by Boroughs, Lindsey K., Antonyak, Marc A., Johnson, Jared L., Cerione, Richard A.

“…Cell migration is essential for several important biological outcomes and is involved in various developmental disorders and disease states including cancer…”
Get full text

LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS -Mutant Lung Adenocarcinoma by Galan-Cobo, Ana, Sitthideatphaiboon, Piyada, Qu, Xiao, Poteete, Alissa, Pisegna, Marlese A, Tong, Pan, Chen, Pei-Hsuan, Boroughs, Lindsey K, Rodriguez, Mirna L M, Zhang, Winter, Parlati, Francesco, Wang, Jing, Gandhi, Varsha, Skoulidis, Ferdinandos, DeBerardinis, Ralph J, Minna, John D, Heymach, John V

“…In -mutant lung adenocarcinoma, tumors with LKB1 loss (KL) are highly enriched for concurrent mutations, which activate the KEAP1/NRF2 pathway (KLK). Here, we…”
Get full text

Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells by Rajagopalan, Kartik N, Egnatchik, Robert A, Calvaruso, Maria A, Wasti, Ajla T, Padanad, Mahesh S, Boroughs, Lindsey K, Ko, Bookyung, Hensley, Christopher T, Acar, Melih, Hu, Zeping, Jiang, Lei, Pascual, Juan M, Scaglioni, Pier Paolo, DeBerardinis, Ralph J

“…Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose…”
Get full text

A Novel Mechanism by Which Tissue Transglutaminase Activates Signaling Events That Promote Cell Survival by Boroughs, Lindsey K., Antonyak, Marc A., Cerione, Richard A.

“…Tissue transglutaminase (tTG) functions as a GTPase and an acyl transferase that catalyzes the formation of protein cross-links. tTG expression is frequently…”
Get full text

A renal cell carcinoma tumorgraft platform to advance precision medicine by Elias, Roy, Tcheuyap, Vanina T., Kaushik, Akash K., Singla, Nirmish, Gao, Ming, Reig Torras, Oscar, Christie, Alana, Mulgaonkar, Aditi, Woolford, Layton, Stevens, Christina, Kettimuthu, Kavitha Priya, Pavia-Jimenez, Andrea, Boroughs, Lindsey K., Joyce, Allison, Dakanali, Marianna, Notgrass, Hollis, Margulis, Vitaly, Cadeddu, Jeffrey A., Pedrosa, Ivan, Williams, Noelle S., Sun, Xiankai, DeBerardinis, Ralph J., Öz, Orhan K., Zhong, Hua, Seshagiri, Somasekar, Modrusan, Zora, Cantarel, Brandi L., Kapur, Payal, Brugarolas, James

“…Renal cell carcinoma (RCC) encompasses a heterogenous group of tumors, but representative preclinical models are lacking. We previously showed that…”
Get full text

In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma by Kaushik, Akash K, Tarangelo, Amy, Boroughs, Lindsey K, Ragavan, Mukundan, Zhang, Yuanyuan, Wu, Cheng-Yang, Li, Xiangyi, Ahumada, Kristen, Chiang, Jui-Chung, Tcheuyap, Vanina T, Saatchi, Faeze, Do, Quyen N, Yong, Cissy, Rosales, Tracy, Stevens, Christina, Rao, Aparna D, Faubert, Brandon, Pachnis, Panayotis, Zacharias, Lauren G, Vu, Hieu, Cai, Feng, Mathews, Thomas P, Genovese, Giannicola, Slusher, Barbara S, Kapur, Payal, Sun, Xiankai, Merritt, Matthew, Brugarolas, James, DeBerardinis, Ralph J

“…Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed the metabolism of…”
Get full text

Abstract 4710: Evaluation of the glutaminase inhibitor CB-839 in non-small cell lung cancer by Boroughs, Lindsey K., Chen, Pei-Hsuan, Cai, Ling, Rodriguez, Mirna, Zhang, Winter, Huffman, Kenneth E., Byers, Lauren A., Girard, Luc, Gazdar, Adi F., Heymach, John V., White, Michael A., Minna, John D., Emberley, Ethan, Pan, Alison, Parlati, Frank, DeBerardinis, Ralph J.

“…Abstract Glutamine is an abundant nutrient used by cancer cells to support energetic and biosynthetic pathways. Given that many cancer cells exhibit glutamine…”
Get full text